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Neratinib

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Identification
Molecular formula
C30H29N7O6S
CAS number
698387-09-6
IUPAC name
N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide
State
State

At room temperature, Neratinib is in a solid state, typically found as a crystalline powder. It remains stable under standard temperature and pressure conditions.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
753.50
Boiling point (Kelvin)
1 026.65
General information
Molecular weight
556.66g/mol
Molar mass
556.5660g/mol
Density
1.4063g/cm3
Appearence

The compound is typically a white to pale-yellow crystalline powder. Its appearance can vary slightly depending on purity and exact form, but generally it maintains a consistent granular or powder-like structure.

Comment on solubility

Solubility of N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide

The solubility of N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide (C30H29N7O6S) can be described with a focus on several significant factors:

  • Polarity: The presence of multiple polar functional groups, such as hydroxyl and amide functional groups, suggests that this compound may exhibit higher solubility in polar solvents like water, compared to nonpolar solvents.
  • Molecular Structure: The complex structure, characterized by multiple domains, influences how well it interacts with solvent molecules, affecting its overall solubility behavior.
  • pH Dependency: Being a compound containing amine and carboxamide functional groups, the solubility may vary with changes in pH, suggesting that solubility could be enhanced in more acidic or basic solutions.
  • Temperature Effects: Like many compounds, solubility may increase with rising temperature, although specific studies would be needed to quantify this relationship for this particular compound.

In summary, the solubility of this compound is likely influenced by its polar characteristics, structural complexity, and external conditions such as pH and temperature. Understanding these factors is crucial when considering its application in various chemical processes.

Interesting facts

Exploring N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide

N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide is a fascinating compound that has captured the attention of researchers due to its unique structural features and potential applications. Let's delve into some intriguing aspects of this chemical compound:

  • Multi-functional Moieties: This compound contains multiple functional groups, including a pyridine ring and a sulfonyl group, which contribute to its diverse reactivity and interaction with biological systems.
  • Pharmacological Potential: The presence of the sulfonamide group and the pyridine moiety suggests that this compound may have potential as a pharmaceutical agent. Sulfonamides have historically been significant in medicine, especially as antibiotics.
  • Structure-Activity Relationship (SAR): The detailed structural features of this compound allow for extensive studies in SAR, where modifications can lead to better efficacy or reduced side effects, fostering innovation in drug design.
  • Target Identification: As a candidate for further research, understanding the target proteins and pathways of this compound is critical for assessing its therapeutic applicability.

The molecule's intricate design, with features that enable specific interactions with biological targets, emphasizes the importance of exploring such compounds in the realm of medicinal chemistry. Researchers are continuously seeking to unlock the therapeutic potential of complex organic compounds like this one, inspiring future studies aiming at optimizing their performance.

As one prominent scientist noted, "The structure of a molecule often dictates its function, and in the case of N-[1-[[2-hydroxy-3-[(4-phenoxyphenyl)sulfonylamino]propyl]carbamoyl]-3-methyl-butyl]pyridine-4-carboxamide, the potential applications in health science are particularly compelling."