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Bortezomib

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Identification
Molecular formula
C19H25B1N4O4
CAS number
179324-69-7
IUPAC name
N-[1-[[2-(2-aminoethylamino)-1-methyl-2-oxo-ethyl]carbamoyl]-2,2-dimethyl-propyl]-2-[2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanamide
State
State

At room temperature, Bortezomib is a solid.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
596.00
Boiling point (Kelvin)
869.15
General information
Molecular weight
384.24g/mol
Molar mass
384.2440g/mol
Density
1.2870g/cm3
Appearence

Bortezomib is typically seen as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[1-[[2-(2-aminoethylamino)-1-methyl-2-oxo-ethyl]carbamoyl]-2,2-dimethyl-propyl]-2-[2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanamide

The solubility of the compound N-[1-[[2-(2-aminoethylamino)-1-methyl-2-oxo-ethyl]carbamoyl]-2,2-dimethyl-propyl]-2-[2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanamide (C19H25B1N4O4) is a complex issue due to its intricate structure and functional groups. When discussing solubility, it's helpful to consider several factors:

  • Polarity: The presence of polar functional groups, such as amino and hydroxy groups, can increase solubility in polar solvents like water.
  • Hydrogen Bonding: The ability of this compound to form hydrogen bonds may enhance its solubility, especially in aqueous environments.
  • Molecular Weight: With a molecular weight of 383.43 g/mol, higher molecular weight compounds may exhibit lower solubility due to decreased interaction with solvent molecules.
  • Concentration Effects: At certain concentrations, solubility can be influenced by the saturation of the solvent, leading to potential precipitation.

In conclusion, while the detailed solubility data for this compound might not be readily available, it is likely to show varying degrees of solubility depending on the solvent used and the surrounding conditions. As a valuable exercise, researchers often investigate solubility behaviors to understand better the compound’s potential applications and interactions in different environments.

Interesting facts

Interesting Facts about N-[1-[[2-(2-aminoethylamino)-1-methyl-2-oxo-ethyl]carbamoyl]-2,2-dimethyl-propyl]-2-[2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanamide

This compound, often referred to informally as a peptide analog, showcases a fascinating mixture of amino acid motifs that make it particularly relevant in the field of medicinal chemistry. Here are some intriguing insights:

  • Peptide-like Structure: The presence of peptide bonds in this compound indicates that it may interact with biological systems in ways similar to natural peptides, potentially influencing pathways related to cell signaling or metabolism.
  • Multiple Functional Groups: The compound contains various functional groups, including amino, carbamoyl, and hydroxy moieties. This diversity allows for a range of reactivity and specificity in biological applications.
  • Potential Therapeutic Uses: Researchers are often interested in compounds like this for their potential use in drug design, particularly in targeting specific receptors or enzymes in a disease state.
  • Synthetic Pathways: The complex structure of this compound often necessitates advanced synthetic techniques, making it a subject of study in synthetic organic chemistry labs.
  • Interactions with Biological Molecules: Due to its structural complexity, the compound may demonstrate significant interactions with proteins and nucleic acids, paving the way for studies on binding affinities and mechanisms.

As noted by one of the scholars in the field, "The intricate balance of functional groups within complex molecules like this often mirrors the delicate interplay found within living organisms themselves." This encapsulates the importance of studying such compounds in the quest for new therapeutic agents and understanding biological processes at a molecular level.

In conclusion, the exploration of N-[1-[[2-(2-aminoethylamino)-1-methyl-2-oxo-ethyl]carbamoyl]-2,2-dimethyl-propyl]-2-[2-(hydroxyamino)-2-oxo-ethyl]-4-methyl-pentanamide not only sheds light on its potential applications but also contributes to the broader tapestry of chemical understanding as we continue to unravel the complexities of life at the molecular scale.

Synonyms
TAPI-2
TNF Protease Inhibitor 2
187034-31-7
N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide
med.21724, Compound 12
CHEMBL5270233
SCHEMBL12561536
INH-3852-PI
BDBM429240
N-[1-[[1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide