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Thienopyridine sulfonamide

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Identification
Molecular formula
C21H20N4O3S2
CAS number
.null
IUPAC name
N-[1-[(1-amino-7-isoquinolyl)methyl]-2-oxo-pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide
State
State

The compound is a solid at room temperature. It is typically stored in a dry and cool environment to prevent degradation. The compound has low solubility in water but can dissolve in organic solvents such as DMSO and methanol commonly used in laboratory settings.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
421.50g/mol
Molar mass
421.4950g/mol
Density
1.2300g/cm3
Appearence

The compound presents as a pale yellow crystalline powder. It is generally considered a solid at room temperature with an appearance that can vary from off-white to light yellow depending on its purity and the specific sample. Thieno[3,2-b]pyridine derivatives can have distinct aromatic characteristics due to the conjugated ring systems.

Comment on solubility

Solubility Characteristics

N-[1-[(1-amino-7-isoquinolyl)methyl]-2-oxo-pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide, with the chemical formula C21H20N4O3S2, exhibits a rather intriguing solubility profile. Generally, the solubility of a compound can be influenced by various factors, including its molecular structure, the nature of functional groups, and the presence of polar or non-polar regions. In case of this sulfonamide, several aspects are worth mentioning:

  • Polarity: The presence of sulfonamide and oxo functional groups suggests that the compound may possess moderate to high polarity, favoring solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds might enhance solubility in aqueous solutions, particularly through interactions with water molecules.
  • Solvent Compatibility: It may also demonstrate varying degrees of solubility in organic solvents, depending on their polarity. Non-polar solvents may not solvate the compound effectively due to its polar characteristics.

In summary, the solubility of this compound is likely to be influenced by its structural characteristics. As a general rule of thumb, "like dissolves like"; hence, this compound would be expected to show better solubility in polar environments compared to non-polar ones. Thus, careful consideration of the solvent choice is crucial for any applications involving this compound.

Interesting facts

Interesting Facts about N-[1-[(1-amino-7-isoquinolyl)methyl]-2-oxo-pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide

This unique compound is a derivative of thieno[3,2-b]pyridine and has drawn interest in medicinal chemistry due to its potential pharmacological properties. Here are some engaging highlights:

  • Therapeutic Potential: This compound shows promise as an inhibitor in various biological pathways, making it of interest in drug discovery, particularly for diseases related to the neurochemical system.
  • Structural Complexity: Its intricate structure features multiple functional groups, including a sulfonamide group and a pyrrolidine moiety, which can interact with biomolecules in versatile ways.
  • Isoquinoline Influence: The presence of an isoquinolyl group contributes to the compound's biological activity, enhancing its affinity for specific biological targets.
  • Research Focus: Studies are ongoing to explore the selective inhibition properties of this compound against certain enzymes, making it a focal point in understanding therapeutic interventions.

"The future of medicinal chemistry lies in the design of complex molecules with high specificity," says a well-known researcher in the field, highlighting the significance of compounds like this in modern drug design.

In conclusion, N-[1-[(1-amino-7-isoquinolyl)methyl]-2-oxo-pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide stands out as a fascinating example of how intricate chemical structures can lead to promising therapeutic avenues. As research progresses, it holds the potential to contribute significantly to the fight against various diseases.

Synonyms
SCHEMBL12589596
PD038886