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Atorvastatin

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Identification
Molecular formula
C33H35FN2O5
CAS number
134523-03-8
IUPAC name
methyl 3-methyl-2-[[2-[[2-[(4-phenylphenyl)methylamino]-3-sulfanyl-propanoyl]amino]acetyl]amino]butanoate
State
State

Atorvastatin is in a solid crystalline state at room temperature.

Melting point (Celsius)
159.80
Melting point (Kelvin)
432.90
Boiling point (Celsius)
785.80
Boiling point (Kelvin)
1 059.00
General information
Molecular weight
558.65g/mol
Molar mass
558.6460g/mol
Density
1.2000g/cm3
Appearence

Atorvastatin is a white to off-white crystalline powder. It is practically insoluble in aqueous solutions of pH 4 and below. It is slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, very slightly soluble in ethanol, and practically insoluble in acidic solutions.

Comment on solubility

Solubility of Methyl 3-Methyl-2-[[2-[[2-[(4-Phenylphenyl)methylamino]-3-Sulfanyl-Propanoyl]amino]Acetyl]amino]Butanoate

Understanding the solubility of a compound like methyl 3-methyl-2-[[2-[[2-[(4-phenylphenyl)methylamino]-3-sulfanyl-propanoyl]amino]acetyl]amino]butanoate (C33H35FN2O5) is crucial for its practical applications in various fields, such as pharmaceuticals and materials science. Solubility can significantly influence a compound's bioavailability, efficacy, and interaction with other substances.

Factors Influencing Solubility

The solubility of this compound can be affected by several key factors:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Temperature: Typically, an increase in temperature leads to an increase in solubility for most solids.
  • pH Levels: For compounds containing acidic or basic groups, solubility may vary with changes in pH.
  • Interactions: The ability to form hydrogen bonds or other interactions with solvent molecules plays a vital role.

Considering the complex structure of methyl 3-methyl-2-[[2-[[2-[(4-phenylphenyl)methylamino]-3-sulfanyl-propanoyl]amino]acetyl]amino]butanoate, its solubility profile is likely to be:

  • Moderate to low in water, due to its large hydrophobic aromatic groups.
  • Higher in organic solvents, such as ethanol or DMSO, where it can engage more favorably with solvent molecules.

In conclusion, understanding the solubility of this compound is essential for its effective use. As the famous saying goes, "The solvent makes the solution." Careful evaluation of solubility not only enhances formulation design but also improves the compound's performance in intended applications.

Interesting facts

Interesting Facts About Methyl 3-Methyl-2-[[2-[[2-[(4-Phenylphenyl)methylamino]-3-sulfanyl-propanoyl]amino]acetyl]amino]butanoate

This complex compound showcases the intricate beauty of organic chemistry by incorporating multiple functional groups and structural features. Here are some noteworthy aspects:

  • Diverse Structure: The molecular architecture includes a combination of methyl groups, amine, sulfanyl, and acyl functionalities, which contribute to its biological activity.
  • Biological Importance: Compounds like this one are often investigated for their potential pharmacological effects. They may interact with biological systems in ways that suggest uses in pharmaceuticals or bioactive materials.
  • Research Significance: The complexity of the structure indicates that it could exhibit interesting properties warranting further research, particularly in the realms of medicinal chemistry and drug development.
  • Potential Applications: The presence of multiple aromatic rings may enhance lipophilicity, potentially affecting the compound's absorption and distribution in biological systems.

In the words of renowned chemists, "The true beauty of chemistry lies not in the simple compounds but in the complex relationships built between their atoms." This compound is a testament to that beauty, representing a convergence of various chemical principles that can lead to novel discoveries.

Overall, methyl 3-methyl-2-[[2-[[2-[(4-phenylphenyl)methylamino]-3-sulfanyl-propanoyl]amino]acetyl]amino]butanoate serves as an exciting topic for study, illustrating how intricate designs in molecular arrangement can lead to significant functional outcomes in biological and chemical contexts.

Synonyms
PD036053