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Clopidogrel

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Identification
Molecular formula
C16H16ClNO2S
CAS number
113665-84-2
IUPAC name
methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
State
State

At room temperature, clopidogrel is in a solid state, and it appears as a powder.

Melting point (Celsius)
109.50
Melting point (Kelvin)
382.65
Boiling point (Celsius)
325.30
Boiling point (Kelvin)
598.45
General information
Molecular weight
322.82g/mol
Molar mass
322.8210g/mol
Density
1.5104g/cm3
Appearence

Clopidogrel is a white to off-white powder. It is not hygroscopic and is practically insoluble in water at pH ranging from 1 to 7. However, it is soluble in methanol and slightly soluble in methylene chloride.

Comment on solubility

Solubility of Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate

The solubility characteristics of methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate (C16H16ClNO2S) can be intriguing, especially given the complex structure and the presence of various functional groups.

Generally, the solubility of a compound in solvents can be influenced by several factors, including:

  • Polarity: The presence of polar functional groups can lead to increased solubility in polar solvents.
  • Molecular Structure: The thienopyridine core can affect solubility owing to its heterocyclic nature.
  • Hydrophobic Interactions: The aromatic rings and hydrocarbon parts may induce hydrophobic interactions, affecting solubility in non-polar solvents.

While specific solubility data for this compound may be limited, we can somewhat speculate:

  • It is anticipated to have moderate solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • However, it might demonstrate low solubility in water due to its substantial hydrophobic characteristics.

In conclusion, the solubility of methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate likely varies significantly depending on the solvent used, and further experimental analysis would provide deeper insights into its solubility profile.

Interesting facts

Interesting Facts about Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate

This compound is a fascinating example of organic chemistry and its applications in medicinal chemistry. Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate exhibits several noteworthy attributes:

  • Structural Complexity: The compound features a unique thieno[3,2-c]pyridine core, which is significant in drug design and development due to its biological activity.
  • Pharmacological Potential: Compounds bearing the thieno[3,2-c]pyridine structure often demonstrate diverse pharmacological activities, making them valuable in medicinal chemistry research.
  • Chlorine Atom: The presence of a chlorine substituent in the aromatic ring enhances the compound's lipophilicity, which can influence its bioavailability and interaction with biological targets.
  • Applications: It may serve as a lead compound in the synthesis of new drugs, particularly in treating neurological disorders or as antitumor agents.

In the words of a renowned chemist, "The beauty of organic synthesis lies in the ability to construct complex molecules that may hold the key to future therapeutics." This compound exemplifies this ethos, showcasing the creativity and innovation inherent in chemistry.

Moreover, the study of such compounds enriches our understanding of structure-activity relationships (SAR), paving the way for the development of targeted therapies and improving the overall efficacy of medicinal compounds.

In summation, methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate is not only complex in structure but also rich in potential, making it a significant subject of study in the field of chemistry.

Synonyms
90055-48-4
(+/-)-clopidogrel
Clopidogrelum
methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4h)-yl)acetate
MX75HY8K68
Clopidogrelum [Latin]
racemic Clopidogrel
(+-)-Clopidogrel
NCGC00159321-02
RAC-CLOPIDOGREL
(RS)-CLOPIDOGREL
UNII-MX75HY8K68
94188-84-8
SCHEMBL1031319
CHEMBL1333662
SCHEMBL14009483
CLOPIDOGREL, (+/-)-
DTXSID70861221
CHEBI:103977
HMS3373C16
(+)-(S)-Methyl 2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c ] pyridin-5-yl) acetate monosulfate
BCP04258
AC-275
AKOS008101989
PB39635
(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester
Thieno(3,2-c)pyridine-5(4H)-acetic acid, alpha-(2-chlorophenyl)-6,7-dihydro-, methyl ester
NCGC00159321-03
NCGC00159321-04
AS-88429
SY009747
DB-011524
CS-0129142
NS00008954
pound inverted exclamation markA)-Clopidogrel
G78873
EN300-1666523
L000860
BRD-A93269281-003-01-0
Q27181214
Z286869270
(+) Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+) Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+)(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester
(+)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester
(+)-methyl (2-chlorophenyl)(6,7-dihydro-4h thieno[3,2-c]pyrid-5-yl)acetate
(+)-methyl (2-chlorophenyl)-(6,7-dihydro-4h thieno[3,2-c]pyrid-5-yl)acetate
(+)-Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+)Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+)Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+/-)-Methyl (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate
(+/-)-methyl alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate
2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester
2-chlorophenyl(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester
Methyl (+)-(S)-.alpha.-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate
Methyl (S)-(+)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
methyl 2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate
methyl2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4h)-yl)acetate
Racemic methyl alpha-(4,5,6,7-tetrahydro-5-thieno[3,2-c]pyridyl)(2-chlorophenyl)acetate
( inverted exclamation markA)-Clopidogrel hydrochloride,Methyl2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetatehydrochlorid
THIENO(3,2-C)PYRIDINE-5(4H)-ACETIC ACID, .ALPHA.-(2-CHLOROPHENYL)-6,7-DIHYDRO-, METHYL ESTER