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Everolimus

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Identification
Molecular formula
C53H83NO14
CAS number
159351-69-6
IUPAC name
methyl (1R,9R,10S,11R,12R,19R)-11-acetoxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
State
State
Everolimus is typically found in its solid form as a crystalline powder at room temperature.
Melting point (Celsius)
179.00
Melting point (Kelvin)
452.15
Boiling point (Celsius)
451.00
Boiling point (Kelvin)
724.15
General information
Molecular weight
958.22g/mol
Molar mass
958.2240g/mol
Density
1.0000g/cm3
Appearence
Everolimus appears as a white to off-white powder. It lacks any distinct odor and features a crystalline structure. It is hydrophobic in nature, typically used in the form of tablets for medical prescriptions.
Comment on solubility

Solubility of Methyl (1R,9R,10S,11R,12R,19R)-11-acetoxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

The solubility of complex organic compounds, such as the one represented by the formula C53H83NO14, can often be multifaceted and heavily influenced by various factors. Here are some important considerations:

  • Polarity: Compounds that contain polar functional groups will generally exhibit increased solubility in polar solvents like water. Conversely, the presence of large hydrophobic regions often leads to poor solubility in such media.
  • Solvent Compatibility: The choice of solvent is critical. For a compound with extensive carbon chains and multiple functional groups, solubility may improve in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Temperature Effects: Increased temperature usually enhances solubility for solid solutes due to greater kinetic energy, promoting interactions with the solvent.
  • Concentration Levels: A solute may have a limit to its solubility, beyond which precipitation occurs. This saturation limit is crucial for applications such as drug formulation.

It is essential to note that understanding the solubility profile of a compound not only aids in practical applications but also provides insights into its reactivity and interaction with biological systems. As with many compounds, conducting experimental solubility tests will yield the most accurate information regarding its behavior in various environments. Ultimately, solubility is a defining characteristic that influences a compound's functionality and usability across multiple disciplines.

Interesting facts

Interesting Facts about Methyl (1R,9R,10S,11R,12R,19R)-11-acetoxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

This compound is a fascinating example of complex organic chemistry, exemplifying the intricate relationships found in bioactive molecules. As a derivative of a larger parent structure, it features multiple stereocenters, which contributes to its unique spatial configuration. Here are some intriguing aspects of this compound:

  • Structural Complexity: With its numerous rings and substituents, it represents a highly intricate molecular architecture, making it a subject of interest for synthetic chemists.
  • Biological Relevance: Compounds with similar structures often demonstrate significant biological activity, making them valuable in medicinal chemistry, particularly in the development of pharmaceuticals.
  • Stereochemistry: The various stereogenic centers not only provide diverse conformational possibilities but also profoundly influence the compound's interaction with biological targets.
  • Functional Groups: The presence of functional groups such as acetoxy and methoxy serves as key points for further chemical reactions or modifications, enhancing its utility in drug design.

As stated in the literature, "The interplay of structure and function in complex organic molecules is a cornerstone of modern medicinal chemistry." This compound encapsulates that notion, showcasing how detailed understanding and manipulation of molecular structures can lead to breakthroughs in therapeutic possibilities.

In the sphere of research, compounds like this one are vital for advancing our understanding of organic synthesis techniques, particularly in the context of natural product chemistry. Scientists continually explore the potential therapeutic applications of such complex structures, promising exciting developments in the field.

Synonyms
vincristine
22-Oxovincaleukoblastine
Leurocristine
Vinkristin
Vincrystine
57-22-7
Vincristina
leucristine
vincristin
Vincristinum [INN-Latin]
Tecnocris
Oncovine
Vincristina [DCIT]
Oncotcs
rel-Vincristine
Vincristinum
oncovin (brand name)
DTXSID1032278
CHEBI:28445
NSC-67574
22-oxo-vincaleukoblastine
Farmistin
DTXCID9012278
Vincristine (INN)
CCRIS 5763
VIN
HSDB 3199
NCGC00163700-01
NCI-C04864
Vincrstine
EINECS 200-318-1
Leurocristine sulfate
Vincristinum (INN-Latin)
UNII-5J49Q6B70F
(+)-Vincristine
LCR
VCR
CAS-57-22-7
Tecnocris (TN)
22-Oxovincaleukoblastin
1217704-92-1
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
Vincasar (1:1 sulfate salt)
Oncovin (1:1 sulfate salt)
Vincrex (1:1 sulfate salt)
Leurocristine;NSC-67574;22-Oxovincaleukoblastine
Vincristine (Leurocristine)
SCHEMBL3709
CHEMBL90555
GTPL6785
L01CA02
HMS2090E19
Tox21_112067
BDBM50139772
Lilly 37231 (1:1 sulfate salt)
Tox21_112067_1
FV73877
NCGC00163700-02
NCGC00163700-04
NCGC00163700-12
NCGC00263543-01
NCI60_026703
SRI-10749-04
SRI-10749-05
NS00009299
C07204
D08679
Q408977
BRD-K49229349-065-01-6
BRD-K49229349-065-02-4
Vincaleukoblastine, 22-oxo- 22-Oxovincaleukoblastine
200-318-1
methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate