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Tenofovir alafenamide

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Identification
Molecular formula
C21H29N6O5P
CAS number
379270-37-8
IUPAC name
isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate
State
State

At room temperature, Tenofovir alafenamide is typically a solid, especially when referring to its pure and unformulated form.

Melting point (Celsius)
188.50
Melting point (Kelvin)
461.65
Boiling point (Celsius)
760.30
Boiling point (Kelvin)
1 033.45
General information
Molecular weight
476.47g/mol
Molar mass
476.4720g/mol
Density
1.4600g/cm3
Appearence

Tenofovir alafenamide is usually found as an off-white to white powder in its pure form. As a compound, it may present differently when formulated in pharmaceutical preparations, often appearing as a tablet.

Comment on solubility

Solubility of Isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate

The solubility of isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate (C21H29N6O5P) is a complex consideration, influenced by its intricate molecular structure and functional groups. The solubility can generally be described with the following points:

  • Hydrophilicity vs Hydrophobicity: This compound contains both hydrophilic (acetoxymethoxy) and hydrophobic (methyl-phenoxy) segments, suggesting that its solubility may vary significantly in polar and non-polar solvents.
  • Potential Solvent Interactions: The presence of multiple hydroxyl and ester groups may enhance solubility in water and organic solvents, although steric hindrance from bulky groups could reduce interaction with solvent molecules.
  • pH Influence: The solubility may also be affected by the pH of the solvent, which could protonate or deprotonate certain functional groups, altering their polarity and solubility profile.

As a result, one might say, *“Solubility is often a dance between structure and environment.”* Understanding the specific dissolution behavior of this compound requires empirical studies and consideration of the solvent system used.

Interesting facts

Exploring Isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate

Isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate is a complex and fascinating compound that has captured the attention of researchers in the field of medicinal chemistry. Below are some interesting facts that highlight its significance and potential applications:

  • Structural Complexity: This compound combines multiple functional groups and structural motifs, making it a promising candidate for exploration in drug design and development.

  • Biological Activity: The presence of multiple acetate and oxymethyl groups suggests potential bioactivity, particularly in modulating enzyme activity or interacting with biological membranes.

  • Medicinal Applications: Compounds with similar structures have been investigated for anti-cancer and anti-inflammatory properties. Thus, isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate could be explored in clinical research.

  • Importance of Linkages: The multiple ethoxy and anilino linkages in this compound may influence its pharmacokinetics, increasing solubility or enhancing absorption.

  • Potential Synthesis Pathways: Its intricate structure suggests various synthetic pathways which could involve novel chemical reactions, thus pushing forward research in synthetic organic chemistry.

As researchers continue to dissect the properties and potentials of isopropenyloxymethyl 2-[N-[2-(acetoxymethoxy)-2-oxo-ethyl]-2-[2-[2-[bis[2-(acetoxymethoxy)-2-oxo-ethyl]amino]-5-methyl-phenoxy]ethoxy]-4-methyl-anilino]acetate, it stands as a testament to the complexity of modern compound exploration. Further studies could unveil new therapeutic avenues that this compound might support, illustrating the ever-expanding possibilities within the realm of chemistry.