Interesting facts
Interesting Facts About Hydroxyurea
Hydroxyurea is a fascinating compound with a variety of significant applications, particularly in the field of medicine. Below are some key points that highlight its importance:
- Anticancer Agent: One of the most notable uses of hydroxyurea is as an anticancer drug. It is primarily used in the treatment of certain types of leukemia and skin cancer by inhibiting the growth of cancerous cells.
- Sickle Cell Disease Treatment: Hydroxyurea has been revolutionary in the management of sickle cell disease. It helps to increase fetal hemoglobin levels, which can reduce the frequency of painful crises and the need for blood transfusions.
- Mechanism of Action: This compound works by disrupting the process of DNA synthesis. By inhibiting ribonucleotide reductase, hydroxyurea effectively limits cellular proliferation, which is crucial in both its anticancer and sickle cell therapeutic roles.
- Research Tool: Beyond its clinical applications, hydroxyurea is often utilized in laboratory research as a means of inducing various cellular responses. It plays a role in the study of DNA repair mechanisms and cell cycle regulation.
- Safety Profile: While hydroxyurea is beneficial, it must be used with caution. Potential side effects include suppression of bone marrow function, which necessitates regular monitoring of blood cell counts during treatment.
As a compound that intersects both pharmacology and biochemistry, hydroxyurea illustrates the profound impact that a single molecule can have on treatment protocols and patient outcomes. Its dual role as both a therapy for chronic diseases and a research tool underscores its significance in medical science. As stated by researchers, "Hydroxyurea not only alters the course of disease but also opens doors for understanding the complexities of cellular processes."
In conclusion, hydroxyurea is a prime example of how chemical compounds are integral to advancing healthcare, revealing the intricate connections between chemistry and biology.
Synonyms
hydroxyurea
127-07-1
Hydroxycarbamide
Hydrea
1-HYDROXYUREA
N-Hydroxyurea
Oxyurea
Carbamoyl oxime
Urea, hydroxy-
Biosupressin
Droxia
Carbamohydroxamic acid
Carbamohydroximic acid
Litalir
Hydroxycarbamine
Onco-carbide
Carbamyl hydroxamate
Hydurea
N-Carbamoylhydroxylamine
Hidrix
Hydura
Siklos
Hydroxicarbamidum
Hydroxylurea
Hydreia
Litaler
urea, N-hydroxy-
Hidroxicarbamida
Idrossicarbamide [DCIT]
Carbamohydroxyamic acid
Hydroxycarbamid
Oncocarbide
hydroxy urea
Hydroxyharnstoff
Xromi
SQ 1089
Hydroxycarbamidum
N-Hydroxymocovina
Hydroxylamine, N-carbamoyl-
Hydroxycarbamidum [INN-Latin]
Hydroxyharnstoff [German]
Hidroxicarbamida [INN-Spanish]
N-Hydroxymocovina [Czech]
carbamide oxide
HYDROXY-UREA
Hydroxylamine, N-(aminocarbonyl)-
CCRIS 958
SK 22591
Droxia (TN)
NCI-C04831
HU
MFCD00007943
N-(Aminocarbonyl)hydroxylamine
NSC 32065
NSC-32065
Ammonium ichthosulfonate
Hydroxycarbamide [INN]
SQ-1089
HSDB 6887
HYDREA (TN)
Hydroxyurea [USAN:USP]
UNII-X6Q56QN5QC
NSC32065
8029-68-3
EINECS 204-821-7
BRN 1741548
DTXSID6025438
CHEBI:44423
AI3-51139
Hydroxyurea (Cytodrox)
HYDROXYUREA [MI]
HYDROXYUREA [HSDB]
HYDROXYUREA [IARC]
HYDROXYUREA [USAN]
CHEMBL467
HYDROXYUREA [VANDF]
X6Q56QN5QC
HYDROXYUREA [USP-RS]
HYDROXYCARBAMIDE [JAN]
DTXCID405438
HYDROXYCARBAMIDE [MART.]
HYDROXYCARBAMIDE [WHO-DD]
HYDROXYUREA [ORANGE BOOK]
HYDROXYCARBAMIDE [EMA EPAR]
HYDROXYUREA [USP MONOGRAPH]
HYDROXYCARBAMIDE [EP MONOGRAPH]
NCGC00015520-03
Idrossicarbamide
Hydroxyurea (USAN:USP)
HYDROXYUREA (IARC)
HYDROXYUREA (USP-RS)
NHY
Hydroxyurea (D4)
Hydroxycarbamidum (INN-Latin)
Hidroxicarbamida (INN-Spanish)
HYDROXYCARBAMIDE (MART.)
N-HYDROXY UREA
Mylocel
HYDROXYUREA (USP MONOGRAPH)
HYDROXYCARBAMIDE (EP MONOGRAPH)
CAS-127-07-1
SMR000059149
Hydroxyurea (USP)
Droxia (TM)
Hydrea (TM)
hydroxyaminomethanamide
SR-01000075919
DRG-0253
idroxicarbamide
Hydroxycarbamide (JAN/INN)
hydroxyl urea
Oxeron
Syrea
n-hydroxy-urea
S-phase/G-1 interface inhibitor
aminohydroxamic acid
carbamic acid oxime
Siklos (TN)
BIOSUPPRESSIN
Spectrum_000909
WLN: ZVMQ
Hydrea (Bristol Meyers)
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Hydroxycarbamidum (Latin)
Lopac-H-8627
MolMap_000029
H 8627
NCIMech_000139
Hydroxyurea, 98%, powder
HYDROXY UREA (D4)
Lopac0_000596
BSPBio_002164
KBioGR_000383
KBioSS_001389
4-03-00-00170 (Beilstein Handbook Reference)
MLS001332381
MLS001332382
MLS002153389
DivK1c_000556
SPECTRUM1500344
SPBio_000247
GTPL6822
tetratogen: inhibits ribonucleoside diphosphate reductase
HMS501L18
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
L01XX05
NINDS_000556
Bio1_000451
Bio1_000940
Bio1_001429
HMS1920F09
HMS2091L17
HMS2234I03
HMS3261H14
HMS3373G18
HMS3655K20
HMS3869C03
NCI C04831
Pharmakon1600-01500344
ALBB-028465
HY-B0313
STR02555
Tox21_110168
Tox21_300319
Tox21_500596
BBL009928
BDBM50017811
CCG-35236
NSC757072
s1896
STL145898
AKOS005716276
AKOS006222547
Tox21_110168_1
DB01005
FH09735
LP00596
NSC-757072
SDCCGSBI-0050578.P006
IDI1_000556
NCGC00015520-01
NCGC00015520-02
NCGC00015520-04
NCGC00015520-05
NCGC00015520-06
NCGC00015520-07
NCGC00015520-08
NCGC00015520-09
NCGC00015520-10
NCGC00015520-11
NCGC00015520-20
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCGC00254007-01
NCGC00261281-01
AC-22674
NCI60_002773
WR 83799
SBI-0050578.P004
DB-041849
EU-0100596
H0310
NS00002419
SW218071-2
EN300-82775
A10546
C07044
D00341
Hydroxyurea, Vetec(TM) reagent grade, >=98%
AB00052018-09
AB00052018-10
AB00052018_11
AB00052018_12
Q212272
SR-01000075919-1
SR-01000075919-3
SR-01000075919-8
BRD-K51747290-001-12-3
BRD-K51747290-001-13-1
BRD-K51747290-001-15-6
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
F8880-0905
Z1203577934
Hydroxycarbamide, European Pharmacopoeia (EP) Reference Standard
Hydroxyurea, United States Pharmacopeia (USP) Reference Standard
Solubility of Hydroxyurea (CH4N2O2)
Hydroxyurea is a versatile compound that exhibits noteworthy solubility characteristics. Its solubility in water is quite high, making it a favorable compound for various applications. Below are some key highlights regarding the solubility of hydroxyurea:
The notable solubility of hydroxyurea makes it an important compound in medicinal chemistry, particularly in treating certain types of cancer and sickle cell disease. It is essential to consider solubility not just for efficacy, but also for the formulation of effective and safe pharmaceutical products.