Skip to main content

Tenofovir disoproxil

ADVERTISEMENT
Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
State
State

At room temperature, tenofovir disoproxil is typically encountered as a solid, specifically a crystalline powder form.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
885.10
Boiling point (Kelvin)
1 158.25
General information
Molecular weight
305.18g/mol
Molar mass
305.1800g/mol
Density
2.0080g/cm3
Appearence

Tenofovir disoproxil appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of Hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

The compound hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate, with the formula C9H14N5O4P, exhibits unique solubility characteristics that are noteworthy for its applications. Its solubility can be influenced by several factors, which include:

  • Polarity: The molecular structure, featuring both hydroxyl and phosphate groups, contributes to its overall polarity, suggesting a good potential for solubility in polar solvents such as water.
  • Hydrogen Bonding: The presence of hydroxyl groups enhances the ability to form hydrogen bonds, potentially increasing solubility in aqueous environments.
  • Functional Groups: The dioxo-pyrimidine scaffold may also influence solubility through interactions with other molecules in solution.

In general, compounds like this tend to have better solubility in solvents that can stabilize multiple charges or polar interactions. Therefore, it is expected that this compound would dissolve effectively in:

  • Water (due to polarity)
  • DMSO (Dimethyl sulfoxide) or DMF (Dimethylformamide)

However, as with many complex organic compounds, factors such as temperature, pH, and the presence of other solutes can significantly affect solubility. As a rule of thumb, *the more polar the solvent, the better the solubility for polar compounds.* Understanding these solubility dynamics is crucial for utilizing the compound in various chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about Hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

This compound, while relatively complex, is a fascinating intersection of organic chemistry and biochemistry. Here are some intriguing points about this unique molecule:

  • Structural Complexity: The presence of both a phosphonate group and a pyrimidinone moiety demonstrates the intricate relationships between different functional groups. This structural diversity is often vital in drug design and biochemical processes.
  • Potential Biological Applications: Compounds with similar structures are often explored for their pharmacological properties. These may include roles as enzyme inhibitors or as modulators in biochemical pathways, showcasing how subtle changes in molecular structure can lead to significant biological effects.
  • Phosphorylation Role: Phosphorylation is a crucial biochemical process that regulates a variety of cellular functions including signal transduction and metabolism. This compound may participate in similar phosphate transfer mechanisms, shedding light on potential regulatory roles in biological systems.
  • Research Interest: Due to its multifaceted components, this compound garners interest for research in medicinal chemistry, helping scientists to explore new therapeutics potentially aimed at chronic diseases or infections.
  • Natural vs. Synthetic: While some compounds are derived from natural sources, others, like this one, are often synthesized in laboratories for specific applications, emphasizing the importance of synthetic chemistry in modern science.

In summary, hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate serves as a prime example of how various chemical entities can come together to form compounds with significant biological implications. This complexity not only highlights the beauty of chemistry but also its immense potential in the field of drug discovery and development.

Synonyms
Deoxythymidine triphosphate
[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
1-[2-deoxy-5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-5-methylpyrimidine-2,4(1h,3h)-dione
27821-54-1
SCHEMBL21275938
DTXSID70861903
{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(4-hydroxy-5-methyl-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid
DB-085696
[Hydroxy-[[(2R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
154117-14-3