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Thiotepa

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Identification
Molecular formula
C6H12N3O2P
CAS number
52-24-4
IUPAC name
ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate
State
State
At room temperature, Thiotepa is generally stored as a solid, white crystalline powder. However, in pharmacological preparations, it is usually used in a solution form due to its application and need for precise dosage.
Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
161.50
Boiling point (Kelvin)
434.65
General information
Molecular weight
189.16g/mol
Molar mass
189.1800g/mol
Density
1.1950g/cm3
Appearence

Thiotepa is a colorless, crystalline powder. Due to its chemical nature, it is usually handled in solution form, but the solid form appears crystalline and is almost odorless. When in solution, it is typically clear with no distinct smell.

Comment on solubility

Solubility of Ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate

Ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate, a unique chemical compound with notable characteristics, demonstrates specific solubility behaviors that are essential for its application in various fields. Understanding solubility is key for determining the efficiency of this compound in practical uses.

Key Points of Solubility:

  • Solvent Compatibility: Generally, compounds with polar functional groups tend to have higher solubility in polar solvents like water. Conversely, non-polar solvents may be less effective.
  • Temperature Influence: Solubility can increase with temperature; thus, evaluating the solubility of ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate at various temperatures might show different dissolving capacities.
  • pH Dependency: The solubility may vary depending on the pH of the solution, making it crucial to assess under controlled pH conditions.
  • Interactions with Other Compounds: The interactions, such as hydrogen bonding or ionic interactions, with other solutes can affect its overall solubility.

In summary, while precise solubility data for ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate may require empirical testing, considering factors such as the solvent type, temperature, pH, and potential interactions will aid in predicting its behavior in solution. Understanding these elements is critical for utilizing this compound effectively in chemical applications and reactions.

Interesting facts

Interesting Facts About Ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate

Ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate is a fascinating compound that has garnered attention in the field of medicinal chemistry and agricultural science. Here are some intriguing aspects of this compound:

  • Phosphoryl Compounds: This compound belongs to a class of chemicals known as phosphoryl compounds, which are essential in biochemistry, primarily due to their role in energy transfer and storage.
  • Biological Activity: Ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate exhibits notable biological activity, making it a candidate for further research in drug development.
  • Aziridine Rings: The presence of bis(aziridin-1-yl) groups adds unique properties to the compound. Aziridines are three-membered cyclic amines that are often involved in nucleophilic reactions due to their ring strain, which allows for reactivity in pharmaceutical applications.
  • Potential Applications: Scientists are exploring its potential in cancer therapy and other diseases due to its ability to interact with various biological targets. Such interactions may lead to novel therapeutic agents.
  • Synthetic Routes: The synthesis of this compound involves complex chemical reactions, requiring careful control of conditions to yield the desired structure. This complexity makes studying its synthesis a valuable learning experience for chemistry students.

As researchers continue to explore the applications and mechanisms of this compound, the potential for breakthroughs in medicine and agriculture remains strong. As one researcher eloquently put it, "Understanding the nuances of compounds like ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate opens doors to a myriad of possibilities in science."

The study of such compounds not only enhances our knowledge of chemistry but also promotes the development of innovative solutions in health and environmental sustainability.

Synonyms
Uredepa
302-49-8
Avinar
AB-100
Bis(ethylenimido)phosphorylurethan
AB 100
Ethyl N-(di-1-aziridinylphosphinyl)carbamate
NSC 37095
NSC-37095
ethyl N-[bis(aziridin-1-yl)phosphoryl]carbamate
9V30JZ75AB
Ethyl (di(1-aziridinyl)phosphinyl)carbamate
Ethyl (bis(1-aziridinyl)phosphinyl)carbamate
CARBAMIC ACID, (BIS(1-AZIRIDINYL)PHOSPHINYL)-, ETHYL ESTER
NSC37095
(Bis(1-aziridinyl)phosphinyl)carbamic acid, ethyl ester
Ethyl [bis(1-aziridinyl)phosphinyl]carbamate
Uredepum
Uredepa [USAN:INN]
Uredepum [INN-Latin]
Ethyl [di(1-aziridinyl)phosphinyl]carbamate
[Bis(1-aziridinyl)phosphinyl]carbamic acid, ethyl ester
BRN 0210038
UNII-9V30JZ75AB
AI3-50450
Uredepa (USAN/INN)
UREDEPA [USAN]
UREDEPA [INN]
UREDEPA [MI]
SCHEMBL3724
4-20-00-00049 (Beilstein Handbook Reference)
CHEMBL457157
DTXSID20184295
CHEBI:134904
WLN: T3NTJ A-2PO & MVO2
AKOS040749727
Ethyl di(1-aziridinyl)phosphorylcarbamate
DA-51580
HY-129243
CS-0104390
NS00125380
Ethyl {[di(1-aziridinyl)phosphinyl]carbamate}
D06266
Ethyl {[bis(1-aziridinyl)phosphinyl]carbamate}
Urdepa, AB 100, AB-100, AB100, Avinar
ETHYL (BIS(1-AZIRIDINYL)PHOSPHINOYL)CARBAMATE
ETHYL N-(BIS(1-AZIRIDINYL)PHOSPHINYL)CARBAMATE
Q27273263
{[Bis(1-aziridinyl)phosphinyl]carbamic} acid, ethyl ester
Carbamic acid,N-[bis(1-aziridinyl)phosphinyl]-, ethyl ester
Carbamic acid, {[bis(1-aziridinyl)phosphinyl]-,} ethyl ester ( )
CARBAMIC ACID, N-(BIS(1-AZIRIDINYL)PHOSPHINYL)-, ETHYL ESTER