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Flurazepam

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Identification
Molecular formula
C21H23ClFN3O3
CAS number
17617-23-1
IUPAC name
ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate
State
State
Flurazepam is commonly available in a solid state at room temperature, typically in the form of tablets or capsules.
Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
387.88g/mol
Molar mass
387.8270g/mol
Density
1.4000g/cm3
Appearence

Flurazepam is a white or almost white crystalline powder.

Comment on solubility

Solubility of Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate (C21H23ClFN3O3)

The solubility of ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate is influenced by several factors, including its complex molecular structure. As a benzodiazepine derivative, you can expect the following characteristics regarding its solubility:

  • Polarity: The molecule contains polar functional groups (like the carboxylate and chloride), which can enhance solubility in polar solvents such as water.
  • Solvent Interaction: While it may show some solubility in water, it is likely to be more soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) due to its hydrophobic benzodiazepine core.
  • pH Dependence: The carboxylate moiety may affect solubility based on the pH of the solution; it is more soluble in basic conditions where the carboxylic acid can deprotonate.

In summary, the solubility of C21H23ClFN3O3 is likely to demonstrate:

  1. Increased solubility in polar organic solvents.
  2. Moderate solubility in water based on pH levels.
  3. Potential challenges in formulation due to limited water solubility.

As a result, determining the optimal solvent for applications involving this compound is crucial for achieving desired concentrations and stability.

Interesting facts

Interesting Facts about Ethyl 7-Chloro-5-(2-Fluorophenyl)-2-oxo-1,3-Dihydro-1,4-benzodiazepine-3-carboxylate

This compound is part of the benzodiazepine family, which is renowned for its therapeutic properties. Here are some fascinating insights into this particular derivative:

  • Structure and Stability: The presence of both a chlorine and a fluorine atom in the structure contributes to its unique pharmacological profile and can enhance stability against metabolic degradation.
  • Biological Activity: Compounds structurally related to benzodiazepines are often known for their ability to modulate the action of neurotransmitters in the brain, particularly influencing the gamma-aminobutyric acid (GABA) receptors, which makes them effective anxiolytics and sedatives.
  • Chemical Synthesis: The synthesis of this compound may involve multi-step reactions, often including nucleophilic substitutions and cyclization reactions, showcasing the complexity of synthetic organic chemistry.
  • Potential Applications: Beyond their use in treating anxiety and insomnia, benzodiazepines are also being explored for their neuroprotective effects and potential use in various chronic diseases.
  • Scientific Research: The ongoing study of compounds like this one highlights the importance of structure-activity relationships (SAR) in medicinal chemistry, guiding researchers in the design of new therapeutic agents.

As a part of the ongoing exploration in drug discovery, understanding the nuances of compounds like ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate not only reveals their potential in clinical applications but also enriches our knowledge of chemistry at a molecular level.

Synonyms
ethyl loflazepate
Victan
Meilax
29177-84-2
Ethyl fluclozepate
Loflazepate d'ethyle
Loflazepato de etilo
CM 6912
Loflazepic acid, ethyl ester
Ethylis loflazepas
Ethyl loflazepate [INN:JAN]
Ethylis loflazepas [INN-Latin]
VJB5FW9W9J
Loflazepate d'ethyle [INN-French]
Loflazepato de etilo [INN-Spanish]
EINECS 249-489-4
Meilax (TN)
BRN 0765264
Ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate
1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, ethyl ester
ETHYL LOFLAZEPATE [MI]
ETHYL LOFLAZEPATE [INN]
ETHYL LOFLAZEPATE [JAN]
DTXSID60865475
ETHYL LOFLAZEPATE [MART.]
ETHYL LOFLAZEPATE [WHO-DD]
5-25-08-00124 (Beilstein Handbook Reference)
ethyl flucozepate
Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate
Ethylis loflazepas (INN-Latin)
ETHYL LOFLAZEPATE (MART.)
Loflazepate d'ethyle (INN-French)
Loflazepato de etilo (INN-Spanish)
Ethyl Loflazepate (1.0mg/ml in Acetonitrile)
UNII-VJB5FW9W9J
Azutolem
Medetax
Sukarnase
Bigson
Ronlax
DEA No. 2758
3-Aminophenol 4-Methylbenzenesulfonate (Ester); m-Aminophenol p-Toluenesulfonate; m-Aminophenol p-Toluenesulfonate (Ester)
Ethyl loflazepic acid
CM-6912
ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate
SCHEMBL156702
CHEMBL1213460
Ethyl loflazepate (JP18/INN)
CHEBI:31573
DTXCID40813878
N05BA18
DB01545
NS00004645
D01293
Q5404460
Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate #
(E)-ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylate
249-489-4
ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylate