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Ethyl 2-bromoacetate

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Identification
Molecular formula
C4H7BrO2
CAS number
105-36-2
IUPAC name
ethyl 2-bromoacetate
State
State
At room temperature, ethyl 2-bromoacetate exists as a liquid. It is often used in industrial and laboratory settings and should be handled with care due to its potential hazards.
Melting point (Celsius)
-32.00
Melting point (Kelvin)
241.15
Boiling point (Celsius)
146.00
Boiling point (Kelvin)
419.15
General information
Molecular weight
167.00g/mol
Molar mass
167.0220g/mol
Density
1.5080g/cm3
Appearence
Ethyl 2-bromoacetate is a colorless liquid. It is typically clear and transparent, resembling water in its fluidity and optical properties. However, caution must be taken as its fumes can be potent and irritating.
Comment on solubility

Solubility of Ethyl 2-bromoacetate

Ethyl 2-bromoacetate, with the chemical formula C4H7BrO2, exhibits interesting solubility characteristics that can vary based on the solvent used.

Generally, ethyl 2-bromoacetate is:

  • Soluble in organic solvents: It dissolves readily in substances like ethanol, acetone, and various hydrocarbons.
  • Moderately soluble in water: While it does possess some degree of solubility in water due to the presence of the ester group, it is not highly soluble, typically ranging around a few grams per liter.

Factors influencing its solubility include:

  1. Polarity: The polar nature of the bromoacetate group enhances its ability to interact with polar solvents.
  2. Temperature: Increased temperatures generally improve solubility, allowing for more significant interactions with solvent molecules.
  3. Molecular structure: The size and shape of the ethyl group also affect solubility, with larger alkyl groups generally leading to lower solubility in polar solvents.

In summary, ethyl 2-bromoacetate showcases moderate solubility properties, significantly influenced by both its molecular structure and the nature of the solvent employed. As always, understanding these solubility characteristics is essential for applications in organic synthesis and other chemical processes.

Interesting facts

Interesting Facts about Ethyl 2-Bromoacetate

Ethyl 2-bromoacetate is a fascinating compound with a variety of applications and characteristics that intrigue both chemists and industry professionals.

Key Characteristics:

  • Reactivity: This compound is known for its versatility in organic synthesis. It often acts as an important intermediate in the production of various pharmaceuticals and agrochemicals.
  • Formation of Esters: Ethyl 2-bromoacetate is typically used in the formation of esters through the process of nucleophilic substitution, highlighting its value in organic chemistry.
  • Section of the Electrophile: As a bromo compound, it can serve as a good electrophile, participating in reactions that create more complex molecules.

Applications:

  • Used as a reagent in the Synthesis of β-Amino Acids, which are crucial in drug development.
  • Serves as a building block in the synthesis of other chemical compounds, especially in the pharmaceutical sector.
  • It can also be employed in the synthesis of different functional groups and heterocycles.

Interesting Uses:

Researchers have found ethyl 2-bromoacetate to be vital in studies focusing on chirality and asymmetric synthesis. As a compound that can easily undergo transformations, it has contributed to advancements in creating more targeted and effective drugs.

In the world of chemistry, it's often the small molecules that make the biggest impact, and ethyl 2-bromoacetate is a prime example of how a single compound can pave the way for groundbreaking discoveries!

Synonyms
Ethyl bromoacetate
105-36-2
ETHYL 2-BROMOACETATE
Antol
Bromoacetic acid ethyl ester
Ethyl bromacetate
Ethyl monobromoacetate
Acetic acid, bromo-, ethyl ester
Ethoxycarbonylmethyl bromide
Bromoacetic acid, ethyl ester
ethyl bromo acetate
Ethyl alpha-bromoacetate
CCRIS 6802
ethylbromoacetate
HSDB 5069
NSC 8832
EINECS 203-290-9
UNII-D20KFB313W
UN1603
BRN 0506456
ethyl-2-bromoacetate
DTXSID4020587
AI3-28575
NSC-8832
Acetic acid, 2-bromo-, ethyl ester
Ethyl .alpha.-bromoacetate
DTXCID20587
D20KFB313W
CHEMBL1085948
4-02-00-00527 (Beilstein Handbook Reference)
ETHYL 2-BROMOACETATE [HSDB]
MFCD00000191
UN 1603
2-bromoacetic acid ethyl ester
bromoacetic acid ethyl
ethylbromacetate
Ethylbromoacetat
ethy bromoacetate
ethyl bromoaceate
ethyl bromoactate
ehtyl bromoacetate
ethyl-bromoacetate
ethyl 2bromoacetate
ethyl bromo-acetate
ethyl 2-bromacetate
ethyl 2-bromoaceate
ethyl a-bromoacetate
BrCH2COOEt
Bromoacetic Acid Ethyl Ester; Bromoacetic Acid Ethyl Ester; Ethyl [1,2]Bromoacetate;
BrCH2CO2Et
Ethyl alphabromoacetate
ethyl 2-bromo-acetate
ethyl 2-bromoethanoate
BrCH2CO2CH2CH3
BrCH2CO2C2H5
BrCH2C(O)OC2H5
bromoacetic acid ethylester
bromoacetic acid-ethylester
ETHYL BROMOETHANOATE
bromacetic acid ethyl ester
bromo-acetic acid ethylester
bromoacetic acid-ethyl ester
SCHEMBL5658
WLN: E1VO2
bromo-acetic acid ethyl ester
Bromo acetic acid ethyl ester
monobromoacetic acid ethyl ester
2-bromo-acetic acid ethyl ester
Acetic acid, bromo, ethyl ester
NSC8832
Acetic acid, 2bromo, ethyl ester
alpha-bromoacetic acid ethyl ester
BCP04940
Tox21_200152
BBL027288
BDBM50318514
ETHYL BROMOACETATE (1-13C)
STL372706
(ETHOXYCARBONYL)METHYL BROMIDE
AKOS000118840
FE53758
Ethyl bromoacetate, reagent grade, 98%
NCGC00091081-01
NCGC00091081-02
NCGC00257706-01
BP-21381
CAS-105-36-2
Ethyl bromoacetate [UN1603] [Poison]
DB-029734
B0532
Ethyl bromoacetate, purum, >=97.0% (GC)
NS00021472
D88162
Q413962
203-290-9