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Adefovir Dipivoxil

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Identification
Molecular formula
C8H12N5O4P
CAS number
106941-25-7
IUPAC name
bis[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate
State
State

At room temperature, it is in a solid state as a crystalline powder.

Melting point (Celsius)
246.50
Melting point (Kelvin)
519.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
273.25g/mol
Molar mass
501.4920g/mol
Density
2.3200g/cm3
Appearence

It is a white to off-white crystalline powder.

Comment on solubility

Solubility of bis[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate

The solubility of the compound bis[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate (C8H12N5O4P) is quite intriguing and can be influenced by several factors:

  • Polarity: The presence of phosphate groups generally increases the hydrophilicity of compounds, suggesting a greater potential for solubility in water.
  • Hydrogen Bonding: The molecule features multiple hydroxyl (-OH) and amino (-NH2) groups which can participate in hydrogen bonding with water, enhancing solubility.
  • Size and Structure: The bulky structure, including the purine and tetrahydrofuran moieties, might hinder solubility by steric effects.

Overall, while it is likely that this compound exhibits some level of solubility in polar solvents, the extent of solubility may vary based on the specific conditions such as pH and temperature. As such, these interactions must be considered when predicting or measuring the solubility of this compound in practical applications.

Interesting facts

Interesting Facts about Bis[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] Hydrogen Phosphate

This complex compound is an intriguing representation of how bioactive molecules can be designed and synthesized for potential applications in biochemistry and pharmacology. Here are some fascinating aspects of this compound:

  • Structure and Function: The compound showcases a sophisticated structure that combines elements of purine bases and phosphoryl groups, vital in biological systems. This design suggests potential roles in nucleic acid metabolism and cellular signaling.
  • Biological Significance: Given its components, such as the aminopurine moiety, this compound may exhibit interactions with nucleotides and could influence DNA/RNA synthesis or modifications, making it significant in genetic studies.
  • Therapeutic Potential: The structural features hint at possible uses in drug development, particularly in the realm of cancer research or antiviral agents, where targeting nucleic acid processes is crucial.
  • Synthetic Approaches: The synthesis of such complex molecules often involves intricate multistep processes, highlighting the creativity and skill of chemists. Techniques such as phosphitylation may be employed to achieve the final product.
  • Research Applications: Researchers may explore its properties in various laboratory settings, such as assessing its role as a biochemical tool for understanding enzyme interactions or cellular mechanisms.

Overall, the compound embodies the elegance of chemistry, where the interplay of structure and function can lead to significant discoveries in biological sciences. As noted by many chemists, "The magic of chemistry lies in its ability to unite the minimal with the monumental." This compound is a prime example of that magic.

Synonyms
AC1L1AGT
ApppA
158700-26-6
DTXSID50274294
bis[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
diadenosine triphosphate
AP3A-lyophilized
BIS(ADENOSINE)-5'-TRIPHOSPHATE
Adenosine-(5')-triphospho-(5')-adenosine
DTXCID80225774
QCICUPZZLIQAPA-UHFFFAOYSA-N
Adenosine 5'-(tetrahydrogen triphosphate), P''->5'-ester with adenosine