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Ethoxyhexahydrobenzofuroisoquinolinol

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Identification
Molecular formula
C19H25NO3
CAS number
498905-25-6
IUPAC name
9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
State
State

At room temperature, this compound exists as a solid, typically in the form of a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
445.00
Boiling point (Kelvin)
718.15
General information
Molecular weight
315.41g/mol
Molar mass
315.4080g/mol
Density
1.2300g/cm3
Appearence

The compound is usually found in a crystalline solid form. It may appear as white or off-white crystals, and it is typically stored in a dry and cool place to maintain stability.

Comment on solubility

Solubility of 9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

The solubility of the compound 9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol (C19H25NO3) is influenced by several factors that are crucial for understanding its behavior in various solvents.

Factors Influencing Solubility

  • Polarity: The presence of functional groups such as -O (ether and hydroxy) suggests that the compound has polar characteristics, which may allow it to dissolve in polar solvents like water and alcohols.
  • Hydrophobic Regions: The hydrophobic hydrocarbon portions can limit solubility in highly polar solvents, leading to a better solubility profile in organic solvents such as ethyl acetate or dichloromethane.
  • Temperature: As with many organic compounds, solubility can increase with temperature, making it essential to consider solubility data at various temperatures for practical applications.

In general, while the compound may exhibit some solubility in aqueous solutions, it is likely to show a more favorable solubility profile in organic solvents due to its larger hydrophobic structure. Thus, it is important to conduct specific solubility tests to determine exact solubility parameters under different conditions.

Interesting facts

Interesting Facts about 9-Ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

This unique compound belongs to a fascinating class of organic molecules known for their complex structures and potential biological activities. Here are some interesting insights:

  • Structural Complexity: The compound features a multi-ring structure that includes both benzofuro and isoquinoline frameworks. This structural arrangement contributes to its intriguing chemical properties.
  • Potential Biological Activity: Compounds like this have been studied for their pharmacological potential. Certain derivatives in similar categories have shown promise in areas like analgesic and antipsychotic activities.
  • Natural Sources: Many isoquinoline and benzofuro compounds are derived from plant alkaloids, which have historically been used in traditional medicine practices and continue to serve as a source for drug discovery.
  • Ethoxy Group Influence: The presence of the ethoxy group in this compound may enhance lipophilicity, potentially influencing its interaction with biological membranes and affecting its bioavailability.
  • Research Applications: Scientists are actively exploring compounds of this nature for various applications not just in medicine, but also in materials science and organic electronics, which broadens the scope of research.

As noted by chemists, "The journey from traditional natural products to synthetic analogs often reveals surprising therapeutic potentials." The synthesis and study of complex molecules like this one are crucial in unraveling new pathways in chemical research.

In summary, 9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol represents a fascinating intersection of nature and synthetic chemistry, with the potential to inform the development of new therapeutic agents and materials.

Synonyms
Morphinan-6.alpha.-ol, 7,8-didehydro-4,5.alpha.-epoxy-3-ethoxy-17-methyl-
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-ethoxy-17-methyl-, (5.alpha.,6.alpha.)-
Morphine, 3-O-ethyl-
CHEMBL25918
SCHEMBL14611951
DB-056088