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9-Chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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Identification
Molecular formula
C12H7ClN6O
CAS number
67772-01-4
IUPAC name
9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
State
State

At room temperature, this compound exists in a solid state. The presence of multiple aromatic rings in its structure contributes to its stability as a solid at ambient conditions.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.00
Boiling point (Celsius)
596.10
Boiling point (Kelvin)
869.30
General information
Molecular weight
286.70g/mol
Molar mass
286.7040g/mol
Density
1.4050g/cm3
Appearence

The compound is typically a crystalline solid with a characteristic, possibly fawn color. The structure includes a tricyclic arrangement with heterocyclic components, resulting in a certain degree of complexity in its physical appearance.

Comment on solubility

Solubility of 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

The solubility of 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine (C12H7ClN6O) can be categorized based on its structural characteristics. This compound features a complex heterocyclic framework, which can significantly influence its solubility profile.

Factors Affecting Solubility

  • Polar Groups: The presence of polar functional groups, such as the amino (–NH2) and chloro (–Cl) groups, can enhance solubility in polar solvents, such as water.
  • Hydrophobic Regions: The furan moiety introduces a degree of hydrophobicity, which may reduce solubility in aqueous environments but increase compatibility with organic solvents.
  • Intermolecular Interactions: Hydrogen bonding potential due to amino groups can lead to solubility improvements in polar solvents, while hydrophobic interactions may facilitate solubility in non-polar solvents.

Solitubility Insights

Understanding the solubility of 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine is crucial for its application in pharmaceuticals, as solubility is a key determinant of bioavailability. Researchers often find this compound to exhibit varied solubility characteristics:

  • The solubility may increase in basic or acidic conditions, depending on the stability of protonated or deprotonated forms.
  • Generally, it displays limited solubility in pure water, but its solubility can be enhanced through the use of solubilizing agents or co-solvents.

Overall, the solubility of this compound is influenced by a balance of its hydrophilic and hydrophobic properties, making it a subject of interest for further study in the context of formulation development.

Interesting facts

Interesting Facts about 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

This compound is a fascinating example of the intricate world of heterocyclic chemistry, where multiple ring structures contribute to its unique properties. The complex name reflects its multifaceted structure, combining elements of both triazole and quinazoline frameworks. Here are some engaging aspects of this compound:

  • Pharmacological Significance: Compounds like this often exhibit a variety of biological activities. They can serve as potential candidates in drug design, particularly in the development of anticancer or antihypertensive agents.
  • Structural Diversity: The presence of the furyl group introduces an aromatic character that can enhance the compound's reactivity and solubility, making it a versatile molecule for further synthesis.
  • Chlorination Effects: The introduction of a chlorine atom plays a critical role in modulating the biological activity and pharmacokinetic properties of the compound, facilitating interactions with biological targets.
  • Research Applications: Scientists frequently explore compounds like this for their capabilities in medicinal chemistry research, often investigating their mechanistic pathways to better understand their effects at the molecular level.
  • Synthetic Pathways: The synthesis of such compounds often involves intricate multi-step processes, showcasing the creativity and innovation required in the field of synthetic organic chemistry.

In summary, 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine is not just a chemical entity; it represents a gateway to potential therapeutic applications and an exploration of the chemistry behind complex molecular interactions. As researchers delve into its properties, the implications of this compound could lead to groundbreaking advancements in pharmacology and medicinal chemistry.

Synonyms
Cgs 15943
104615-18-1
CGS-15943
9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
CGS 15943A
CGS15943
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine
CGS-15943A
9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Y5A5D5E2AQ
CHEMBL16687
9-chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
(1,2,4)Triazolo(1,5-c)quinazolin-5-amine, 9-chloro-2-(2-furanyl)-
9-Chloro-2-(2-furanyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-amine
[1,2,4]Triazolo[1,5-c]quinazolin-5-amine, 9-chloro-2-(2-furanyl)-
SMR000449284
SR-01000075210
Tocris-1699
CPD000449284
Lopac-C-199
9-chloro-2-(2-furyl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
[1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)-
CGS-15943, solid
UNII-Y5A5D5E2AQ
Lopac0_000324
GTPL384
MLS000758223
MLS001423961
SCHEMBL1906971
SCHEMBL3844736
CHEBI:92849
DTXSID80146617
CHEBI:131351
HMS2051C13
HMS3261A09
HMS3268O19
HMS3393C13
HMS3412D08
HMS3676D08
HMS3755I05
EX-A4826
Tox21_500324
BDBM50004566
MFCD01529897
PDSP1_001092
PDSP2_001076
AKOS015906465
CCG-100792
CGS-15943?
LP00324
NC00042
SDCCGSBI-0050312.P002
NCGC00015193-01
NCGC00015193-02
NCGC00015193-03
NCGC00015193-04
NCGC00015193-05
NCGC00015193-06
NCGC00015193-07
NCGC00015193-13
NCGC00025264-01
NCGC00025264-02
NCGC00025264-03
NCGC00025264-04
NCGC00261009-01
AC-36616
AS-16373
DA-51809
CGS 15943, 95%
HY-100678
C-199
CS-0019917
EU-0100324
F86436
L000176
Q5010994
SR-01000075210-1
SR-01000075210-3
BRD-K49049886-001-03-8
BRD-K49049886-001-08-7
9-Chloro-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943)
9-chloro-2-(2-furanyl)-1,2,4-triazolo[1.5-c]quinazolin-5-amine
9-chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
9-CHLORO-2-(2-FURANYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
[9-chloro-2-(furan-2-yl)-4H-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-amine
9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo (1,5-c)quinazolin-5-imine
9-chloro-2-(2-furyl)-5-imino-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943)