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Clobetasol Propionate

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Identification
Molecular formula
C25H32ClFO5
CAS number
25122-46-7
IUPAC name
[9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
State
State

At room temperature, Clobetasol Propionate is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
197.50
Melting point (Kelvin)
470.60
Boiling point (Celsius)
545.60
Boiling point (Kelvin)
818.80
General information
Molecular weight
466.97g/mol
Molar mass
466.9690g/mol
Density
1.0600g/cm3
Appearence

Clobetasol Propionate typically appears as a white to creamy-white crystalline powder. It is neither soluble in water nor highly reactive, mainly retaining its form as a stable solid under standard conditions.

Comment on solubility

Solubility of [9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate (C25H32ClFO5)

The solubility of this compound is a fascinating aspect that influences its applications and interactions in various environments. When considering solubility, there are several key factors to keep in mind:

  • Polarity: The presence of nonpolar and polar functional groups can significantly affect how this compound interacts with solvents. The furan-2-carboxylate group may impart some polarity, which can aid solubility in polar solvents like water.
  • Hydrophobicity: Many components, such as the multiple methyl groups and the chloroacetyl side chain, can increase hydrophobic interactions. This may decrease solubility in highly polar solvents.
  • Temperature: Solubility is often temperature-dependent. Increasing the temperature may enhance solubility by providing energy to overcome intermolecular forces.
  • pH Level: The ionization state of the furan-2-carboxylate group can vary with pH, potentially altering solubility in aqueous solutions.

Overall, the solubility of the compound can be characterized as:

  1. Moderate in organic solvents such as ethanol or acetone due to the various functional groups.
  2. Less soluble in water at neutral pH due to the significant hydrophobic character.

Understanding solubility is crucial for the effective utilization and handling of this compound in pharmaceutical and chemical applications. As famously stated, "Like dissolves like," emphasizing the relationship between the compound's structure and its solubility profile.

Interesting facts

Interesting Facts about 9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl furan-2-carboxylate

This compound is a fascinating derivative of natural products, particularly in the realm of synthetic organic chemistry. Here are some interesting points to consider:

  • Pharmacological Potential: Like many compounds that feature intricate cyclic structures, this compound has potential applications in medicinal chemistry. It may exhibit biological activity that is significant in therapeutic contexts, particularly in oncology or endocrinology.
  • Structural Complexity: The large molecular structure, with multiple rings and functional groups, makes this compound a prime candidate for studies involving structure-activity relationships (SAR). These investigations help determine how the chemical structure influences biological activity.
  • Chlorine Substituents: The presence of chlorine atoms, such as in the 9-chloro and 2-chloroacetyl groups, can markedly influence the compound's reactivity and stability. Chlorinated compounds often show enhanced lipophilicity, which may affect their absorption and distribution within biological systems.
  • Natural Product Inspiration: The design of this compound clearly draws inspiration from biologically active natural products, emphasizing how synthetic chemists often mimic nature to develop new drugs.
  • Synthetic Routes: The synthesis of compounds like this one often requires intricate multi-step processes, making it a subject of interest for synthetic chemists. Exploring different synthetic strategies can lead to more efficient pathways in drug development.

As we delve deeper into the world of organic compounds, each structure tells a unique story of potential and purpose. This compound, with its rich background in organic synthesis and medicinal applications, exemplifies the extraordinary creativity behind modern chemistry.

Synonyms
SCHEMBL13026146
DTXSID70861064
AKOS015895318
LS-15182
9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate