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Clobetasol Propionate

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Identification
Molecular formula
C25H32ClO5
CAS number
25122-46-7
IUPAC name
9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, clobetasol propionate is in a solid state. It is primarily used in medical or pharmaceutical applications and is formulated into creams or ointments for topical application.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
467.98g/mol
Molar mass
467.3880g/mol
Density
1.3701g/cm3
Appearence

Clobetasol propionate is a white to cream-colored crystalline powder. It is odorless and is typically available in topical formulations such as creams, ointments, and lotions for pharmaceutical applications.

Comment on solubility

Solubility of 9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one (C25H32ClO5)

The solubility of this compound is an intriguing aspect, especially considering its complex structure and functional groups. Understanding its solubility behavior can provide valuable insight into its potential applications and biological activity.

Key Factors Affecting Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups typically indicates more polar characteristics, enhancing solubility in polar solvents like water.
  • Hydrophobic Components: The large hydrocarbon sections of the molecule may lead to better solubility in non-polar solvents, despite the polar functional groups.
  • pH Dependency: The solubility may also vary with pH changes, particularly because of the acidic or basic nature of the hydroxyl groups.

Overall, while predicting the exact solubility can be complex, one could anticipate that:

  • It may be soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • It might have limited solubility in water but reacts favorably with more polar organic solvents.

In conclusion, the solubility profile of C25H32ClO5 is influenced by both its polar and non-polar characteristics. The interplay of these factors is essential for understanding how this compound behaves in various solutions.

Interesting facts

Interesting Facts about 9-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This compound, a steroid derivative, captures significant interest due to its complex structure and potential applications. Its fascinating characteristics include:

  • Classical Steroid Framework: This molecule belongs to the steroid class, known for its multi-ring structure which is fundamental in various biological activities.
  • Hydroxyl Groups: The presence of multiple hydroxyl (–OH) groups enhances its reactivity and solubility profile, making it a key player in biochemical interactions.
  • Chirality: With several chiral centers in its structure, this compound showcases optical isomerism, which can lead to significantly different biological activities.
  • Potential Medicinal Uses: Research suggests that compounds with similar structures may have applications in anti-inflammatory and anti-tumor therapies.
  • Pharmacophore Insight: The unique arrangement of functional groups provides insights into steroid pharmacophore designs, allowing scientists to model new compounds with desired biological properties.

Furthermore, one cannot overlook the importance of the chlorine atom in altering the properties of the steroid. As noted by many in the field, "Chlorination can significantly enhance the pharmacological profile of steroid compounds." This highlights the role of halogens in medicinal chemistry and drug design.

As research progresses, understanding the nuances of this compound could lead to substantial advancements in pharmacology and therapeutic development.

Synonyms
beclomethasone
Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)-
SCHEMBL13423587
DTXSID50859868
NBMKJKDGKREAPL-UHFFFAOYSA-N
9.alpha.-Chloro-16.beta.-methylprednisolone
BRD-A73385064-001-01-5
9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione #
9-Chloro-11.beta.,17,21-trihydroxy-16.beta.-methyl-pregna-1,4-diene-3,20-dione