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Codeine methylbromide

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Identification
Molecular formula
C21H23NO6
CAS number
125-26-2
IUPAC name
(9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl) acetate
State
State

At room temperature, this compound is typically in a solid state. The solid is stable and does not rapidly decompose in air.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
381.43g/mol
Molar mass
459.5280g/mol
Density
1.3300g/cm3
Appearence

This compound is typically a white crystalline powder. It has no characteristic odor and can appear as fine crystals or crystalline powder.

Comment on solubility

Solubility of (9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl) acetate

The solubility characteristics of the compound (9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl) acetate (C21H23NO6) can be intriguing due to its complex structure and the presence of various functional groups. Here are some key points regarding its solubility:

  • Polar and Nonpolar Interactions: The presence of acetate groups in the structure suggests that the compound may exhibit polar characteristics, which could enhance its solubility in polar solvents like water and alcohols. Conversely, its larger hydrophobic regions may lead to limited solubility in strictly polar solvents.
  • Solvent Choices: It is anticipated that the compound may be more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and possibly dichloromethane, while displaying less favorable solubility in highly polar solvents.
  • Influencing Factors: Factors like temperature, pH, and the presence of other solutes can significantly influence the solubility of this compound. For example, increasing temperature generally enhances solubility for many organic compounds.

The intricate balance of hydrophobic and hydrophilic properties underscores the necessity for experimental determination of solubility for practical applications. Researchers often employ a range of solvents to determine the optimal conditions for solubilizing such complex molecules.

Interesting facts

Interesting Facts about 9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl acetate

This compound is a fascinating member of the isoquinoline class, renowned for its complex structure and unique properties. Here are some interesting points to consider:

  • Origins of Structure: The creation of this compound represents an intricate fusion of various chemical groups—specifically the benzofuro and isoquinoline moieties. This structural complexity often leads to unique interactions within biological systems.
  • Pharmacological Potential: Compounds derived from isoquinoline frameworks are often studied for their potential medicinal applications. They may exhibit a range of activities, such as anti-inflammatory, analgesic, or even antitumor effects, making them valuable in pharmaceutical research.
  • Synthetic Challenges: The synthesis of this molecule requires advanced techniques in organic chemistry, including multiple steps of functionalization to achieve the desired acetoxy and methyl groups. Students and scientists find this synthesis a compelling study of organic methodologies.
  • Biological Activity: Some derivatives of the isoquinoline structure have been shown to interact with neurotransmitter pathways. Thus, this compound may hold promise in the study of neuropharmacology or in the development of drugs targeting mental health disorders.
  • Structural Insights: Its intricate stereochemistry provides a rich area for further study, particularly in stereoselective reactions. Understanding how such structures can influence biological activity opens avenues for targeted drug design.

As a compound that sits at the intersection of organic synthesis and medicinal chemistry, 9-acetoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl acetate showcases the thrilling complexity of chemical compounds and their potential applications in science. It's a reminder of how creativity and precision in chemistry can lead to the development of new solutions in healthcare!

Synonyms
Acetomorphin
Hairy
Harry
White stuff
JOY POWDER
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5.alpha.,6.alpha.)-, diacetate (ester)
Acetomorfin
Eroin
Morphine, diacetyl-
SCHEMBL14463869
DTXSID90859488
GVGLGOZIDCSQPN-UHFFFAOYSA-N
Heroin-D3 (Diacetylmorphine-D3)
BOY
UIA53368
3,6-Diacetoxy-4,5-epoxy-17-methyl-morphin-7-en
17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diyl diacetate
7,8-Dihydro-4,5-.alpha.-epoxy-17-methylmorphinan-3,6-.alpha.-diol diacetate
Morphinan-3,6-.alpha.-diol, 7,8-didehydro-4,5-.alpha.-epoxy-17-methyl-, diacetate
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5.alpha.,6.alpha.)-, diacetate
Morphinan-3,6.alpha.-diol, 7,8-didehydro-4,5.alpha.-epoxy-17-methyl-, diacetate (ester)
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-(5.alpha.,6.alpha.)-, 3,6-diacetate