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Progesterone

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Identification
Molecular formula
C21H30O2
CAS number
57-83-0
IUPAC name
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State
At room temperature, progesterone is typically in a solid-state. It is available in crystalline form, making it suitable for various pharmaceutical formulations.
Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
469.00
Boiling point (Kelvin)
742.15
General information
Molecular weight
314.46g/mol
Molar mass
314.4650g/mol
Density
1.1660g/cm3
Appearence

Progesterone appears as a white crystalline powder that is odorless or has a very slight characteristic odor. It is practically insoluble in water but soluble in alcohol and acetone.

Comment on solubility

Solubility of the Compound C21H30O2

The solubility of (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one is an intriguing subject due to its structural complexity. Understanding the solubility characteristics of this compound can shed light on its potential applications. Here are some key points to consider:

  • Solvent Compatibility: Generally, solubility is influenced by the polarity of the solvent in relation to the compound. C21H30O2 may exhibit varying solubility in:
    • Polar solvents (like water): Expected to be low due to its hydrophobic nature.
    • Non-polar solvents (like hexane): Likely to show higher solubility due to compatibility with the hydrocarbon chains within its structure.
  • Molecular Structure: The presence of acetyl and hydroxyl groups can potentially enhance solubility in certain organic solvents, while also imparting limited hydrophilicity.
  • Temperature Influence: Solubility is often temperature-dependent, where increasing temperatures might favor increased dissolution rates in suitable solvents.
  • Concentration Effects: At higher concentrations, this compound might exhibit unique solubility behavior, including phenomena such as self-aggregation or phase separation.

As a final note, experimental data on solubility are indispensable for definitive conclusions. Knowledge of solubility aids in understanding how this compound might be used or processed in various applications, influencing its behavior in chemical contexts.

Interesting facts

Interesting Facts about (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

This compound, known for its complex structure, belongs to a class of compounds often referred to as steroid derivatives. Its multi-dimensional architecture makes it a fascinating subject of study in organic chemistry and pharmacology.

Key Features:

  • Stereochemistry: The specific stereocenters indicated in the name (8S, 9S, 10R, etc.) are crucial. These configurations influence the biological activity and interactions of the compound in living organisms.
  • Biological Relevance: Compounds like this one are often studied for their potential hormonal effects. They may mimic or influence steroid hormones, making them useful in various therapeutic applications.
  • Mechanism of Action: Understanding how such compounds interact with biological receptors can lead to innovations in drug design, especially in cancer treatment and other endocrine-related disorders.

Moreover, the presence of the acetyl group in its structure enhances its lipophilicity, which could influence its absorption and distribution within biological systems.

As noted by chemists, "The intricate beauty of molecular structures can often reveal untapped therapeutic potential." This highlights the ongoing importance of exploring complex compounds in the quest for new drugs and treatments.

As a student or researcher building on foundational knowledge, this compound exemplifies how adding slight modifications to a molecular structure can lead to significant changes in properties and activities, showcasing the creativity inherent in the field of organic chemistry.

Synonyms
progesterone
57-83-0
Pregn-4-ene-3,20-dione
Agolutin
Crinone
4-Pregnene-3,20-dione
Prometrium
Utrogestan
Progestin
Luteol
Gestormone
Glanducorpin
Pregnenedione
Progesterol
Progesteronum
Progestone
Progestron
Syngesterone
Corlutin
Hormoflaveine
Lutociclina
Methylpregnone
Progestasert
Progestosol
Progestronol
Syngestrets
Corporin
Cyclogest
Flavolutan
Fologenon
Gestone
Gestron
Gynlutin
Gynolutone
Hormoluton
Lingusorbs
Lucorteum
Luteodyn
Luteogan
Luteopur
Luteosan
Luteostab
Luteovis
Lutidon
Lutocylin
Lutoform
Membrettes
Nalutron
Piaponon
Primolut
Progekan
Prolets
Protormone
Syntolutan
Lutren
Lucorteum Sol
Bio-luton
Lutocyclin M
Luteocrin normale
Corlutina
Corluvite
Gesterol
Luteinique
Lutocyclin
Lutromone
Prochieve
Prolidon
Proluton
Prolutone
Lutogyl
Lutex
Lutin
17alpha-Progesterone
Lipo-Lutin
Synovex S
Gynoluton
Projestaject
Percutacrine Luteinique
Gesterol 100
Akrolutin
Gesterol 50
Pregnene-3,20-dione
Cyclogesterin
Endometrin
Progesteron
Prolutin
(S)-Progesterone
3,20-Pregnene-4
Gelbkoerperhormon
Colprosterone
Progestogel
Progeston
Crinone progesterone gel
Progesterona
Gestiron
Lugesteron
Progestol
Vitarrine
Luteol (VAN)
NSC-9704
Lutocuclin M
(S)-4-Pregnene-3,20-dione
Delta(4)-pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
.beta.-Progesterone
delta(sup 4)-Pregnene-3,20-dione
Percutacrine
Progeffik
Utrogest
Luteum
Progesteronum [INN-Latin]
Progesterona [INN-Spanish]
CCRIS 533
HSDB 3389
AI3-51682
Prontogest
Lipolutin
Lutogynon
Estima
Progesterone, micronized
17.alpha.-Progesterone
6alpha-Methylpregn-4-en-17alpha-ol-3,20-dione
Progesterone [Progestins]
NSC 9704
Prometrium (TN)
EINECS 200-350-6
Pregn-4-en-3,20-dione
UNII-4G7DS2Q64Y
NSC 64377
NSC-64377
Crinone (TN)
Pregn-4-ene-3,20-dione, 17alpha-hydroxy-6alpha-methyl-
MILPROSA
DTXSID3022370
CHEBI:17026
.delta.4-Pregnene-3,20-dione
17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
Progesterone (Standard)
delta(Sup4)-pregnene-3,20-dione
component of Cyclogesterin
MFCD00003658
U 3672
4-Pregnen-3,20-dione
.delta.(sup4)-Pregnene-3,20-dione
CHEMBL103
D4-Pregnene-3,20-dione
(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
MLS000028517
4G7DS2Q64Y
DTXCID902370
NSC9704
EC 200-350-6
Progesterone [USP:INN:BAN:JAN]
BIJUVA COMPONENT PROGESTERONE
NSC64377
NCGC00015785-04
SMR000058345
Progesteronum (INN-Latin)
Progesterona (INN-Spanish)
PROGESTERONE (MART.)
PROGESTERONE [MART.]
PROGESTERONE (USP-RS)
PROGESTERONE [USP-RS]
6.alpha.-Methylpregn-4-en-17.alpha.-ol-3,20-dione
17.alpha.-Hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione
Progestan
PROGESTERONE (EP MONOGRAPH)
Progesterone (USP:INN:BAN:JAN)
PROGESTERONE [EP MONOGRAPH]
Pregn-4-ene-3,20-dione, 17.alpha.-hydroxy-6.alpha.-methyl-
PROGESTERONE (USP MONOGRAPH)
PROGESTERONE [USP MONOGRAPH]
SMR000653542
Natural Progesterone
Progesterone (Prometrium)
WLN: L E5 B666 OV MUTJ A1 E1 FV1
SR-01000000088
SR-01000076054
Pregn-4-ene-3, 17.alpha.-hydroxy-6.alpha.-methyl-
BHR-100
Duraprogen
Progestrel
Lutinus
Gelbkorperhormon
Progesto-Life
beta-Progesterone
1dbb
17a-Progesterone
Progesterone Combo
CAS-57-83-0
Progesterone1538
racemic progesterone
Prestwick_411
Progesterone Phenolic
CIDR
mpp22
2aa6
4bb2
Opera_ID_292
P25 Progesterone Cream
P50 Progesterone Cream
P75 Progesterone Cream
Progesterone, >=99%
Prestwick0_000477
Prestwick1_000477
Prestwick2_000477
Prestwick3_000477
Spectrum5_002053
PROGESTERONE [MI]
Cyclogesterin (Salt/Mix)
PROGESTERONE [INN]
PROGESTERONE [JAN]
bmse000482
Epitope ID:116051
PROGESTERONE [HSDB]
SCHEMBL7671
Ferring Pharmaceuticals Inc.
P75 Lav Progesterone Cream
PROGESTERONE [VANDF]
BIDD:PXR0094
Lopac0_000895
BSPBio_000614
MLS000758277
MLS001074187
MLS001423982
MLS002222367
BIDD:ER0547
P0130_SIGMA
PROGESTERONE [WHO-DD]
PROGESTERONE [WHO-IP]
Advanced Formula Progesto-Life
SPBio_002553
.delta.-Pregnene-3,20-dione
BDBM8903
BPBio1_000676
EAZI-BREED CIDR SheepInsert
GTPL2377
Hydroxyprogesterone Caproic acid
EAZI-BREED CIDR CattleInsert
EAZI-BREED CIDR Sheep Insert
HY-N0437R
Progesterone (JP18/USP/INN)
BHR-310
EAZI-BREED CIDR Cattle Insert
ETI-411
G03DA04
MSK2223
PROGESTERONE [GREEN BOOK]
1a28
1h60
HMS1569O16
HMS2051O05
HMS2090J07
HMS2096O16
HMS2230F23
HMS2233P11
HMS3262D12
HMS3713O16
Pregnene, 3,20-dione-delta^4-
PROGESTERONE [ORANGE BOOK]
BCP22000
HY-N0437
Tox21_113157
Tox21_201792
Tox21_300307
Tox21_500895
AC-700
CMC_13406
LMST02030159
Progesterone, 1mg/ml in Acetonitrile
PROGESTERONUM [WHO-IP LATIN]
s1705
AKOS015894908
Progesterone; 4-Pregnene-3,20-dione
CCG-100766
CS-1937
DB00396
DR-2011
FD12045
FP27173
LP00895
NC00016
PROGESTERONE COMPONENT OF BIJUVA
SDCCGSBI-0050870.P002
Progesterone 1.0 mg/ml in Acetonitrile
NCGC00022185-03
NCGC00022185-04
NCGC00022185-05
NCGC00022185-06
NCGC00022185-07
NCGC00022185-08
NCGC00022185-09
NCGC00022185-10
NCGC00022185-11
NCGC00022185-12
NCGC00022185-14
NCGC00022185-21
NCGC00090798-01
NCGC00090798-02
NCGC00254120-01
NCGC00259341-01
NCGC00261580-01
(1S,10S,11S,14S,15S,2R)-14-acetyl-2,15-dimethyl-5-oxotetracyclo[8.7.0.0<2,7>.0 <11,15>]heptadec-6-ene
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
AS-12660
CPD000058345
NCI60_042166
FE-999913
CS-0694805
EU-0100895
NS00010899
P0478
(14beta,17alpha)-pregn-4-ene-3,20-dione
Progesterone, meets USP testing specifications
Progesterone, Vetec(TM) reagent grade, 98%
C00410
D00066
P 0130
Q26963
S00293
Progesterone, VETRANAL(TM), analytical standard
SR-01000000088-5
SR-01000000088-6
SR-01000076054-1
SR-01000076054-4
BRD-K64994968-001-03-6
32104FB6-BF81-4F6E-83C2-024DEEAEB272
Z1501485353
P75 Maxx with Retinol All Natural Progesterone 75 Cream
Pregn-4-ene-3,20-dione;?4-Pregnene-3,20-dione;Agolutin
Progesterone, British Pharmacopoeia (BP) Reference Standard
Progesterone, powder, BioReagent, suitable for cell culture
Progesterone, European Pharmacopoeia (EP) Reference Standard
Progesterone, gamma-irradiated, BioXtra, suitable for cell culture
Progesterone, United States Pharmacopeia (USP) Reference Standard
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture
Progesterone for peak identification, European Pharmacopoeia (EP) Reference Standard
Progesterone for system suitability, European Pharmacopoeia (EP) Reference Standard
Progesterone, Pharmaceutical Secondary Standard; Certified Reference Material
(1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
137940-28-4
200-350-6
753497-20-0