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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(8S,9S,10R,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, estrone is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
440.90
Boiling point (Kelvin)
714.05
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2277g/cm3
Appearence

Estrone appears as a white or creamy white, odorless crystalline powder. The compound is generally solid at room temperature, with a texture that can be noted as powdery.

Comment on solubility

Solubility of (8S,9S,10R,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of the compound specified, a complex steroid-like molecule, can be influenced by various factors due to its intricate structure. Understanding its solubility properties is crucial for applications in pharmaceuticals and material sciences. Here are several key points regarding its solubility:

  • Solvent Polarity: This compound may exhibit differing solubility in polar versus non-polar solvents. Typically, non-polar solvents may dissolve such large organic molecules better.
  • Temperature Dependency: Solubility is often temperature-dependent; increasing temperature can enhance solubility in many organic compounds.
  • Functional Groups: The presence of hydroxyl groups can impart some level of polarity, potentially increasing solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds often increases solubility in water and other polar solvents.

Overall, while general trends can be observed regarding the solubility of complex compounds like this one, the exact solubility must be experimentally determined in relevant solvents to draw definitive conclusions. As the legendary chemist Linus Pauling once noted, "The best way to have a good idea is to have lots of ideas." Thus, diverse experimental approaches are essential in understanding the solubility characteristics.

Interesting facts

Interesting Facts about (8S,9S,10R,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

This complex compound, often known in scientific circles for its significant structural characteristics, belongs to a class of molecules known as steroids. The name alone provides insight into its intricate stereochemistry, which is pivotal in defining its biological activities and properties.

Structural Features

  • Stereochemistry: The specification of multiple stereocenters (8S, 9S, 10R, etc.) indicates that this compound exists in various stereoisomeric forms, each potentially displaying different biological activities.
  • Hydroxyl Group: This compound contains a hydroxyl group, which often enhances solubility in biological systems and can dramatically influence reactivity and binding interactions with biological targets.

Biological Relevance

The compound's unique structure closely resembles natural hormones, making it of great interest in pharmaceuticals and biochemistry. Here are a few points to consider:

  • Potential Therapeutics: Due to its steroid-like framework, it could play a role in hormone replacement therapies.
  • Research Applications: Compounds of this nature are pivotal in studying hormonal pathways and their implications in disease mechanisms.

Quote

A noted biochemist once said, "The complexity of nature's molecules often holds the key to our most significant medical advancements." This compound exemplifies that idea.

In conclusion, this compound is a fascinating case study in the field of chemistry due to its sophisticated structure and remarkable potential applications in medicine and biochemistry. As research continues, the insights gained from studying such compounds could lead to groundbreaking discoveries in health sciences.

Synonyms
145-14-2
DIHYDROPROGESTERONE
20alpha-Hydroxyprogesterone
Dihydrogesterone
20(S)-Hydroxyprogesterone
(20S)-20-Hydroxypregn-4-en-3-one
20alpha-Dihydroprogesterone
20-alpha-Progerol
Pregn-4-en-3-one, 20-hydroxy-, (20S)-
Progesterol-20-alpha
20-alpha-Dihydroprogesterone
20alpha-Progerol
20alpha-Hydroxypregn-4-en-3-one
20a-Hydroxypregn-4-en-3-one
20alpha-Dihydroprognenolone
20-alpha-Hydroxyprogesterone
20alpha-Hydroxypregnen-2-one
NSC 68630
20alpha-Hydroxydihydroprogesterone
20alpha-Hydroxypreg-4-en-3-one
20alpha-Hydroxy-4-pregnen-3-one
20-alpha-Hydroxydihydroprogesterone
Progesterol-20.alpha.
Delta4-Pregnen-20alpha-ol-3-one
Progesterone EP Impurity B
(S)-20-Hydroxypregn-4-en-3-one
EINECS 205-649-5
20.alpha.-Hydroxyprogesterone
BRN 2220567
MLS000028860
20.alpha.-Progerol
Pregn-4-en-20.alpha.-ol-3-one
20.alpha.-Hydroxydihydroprogesterone
45630A64AC
Pregn-4-en-3-one, 20alpha-hydroxy-
Pregn-4-en-3-one, 20.alpha.-hydroxy-
20.alpha.-Dihydroprogesterone
20-.alpha.-Dihydroprogesterone
CHEBI:28453
Pregn-4-ene-20alpha-ol-3-one
4-08-00-01018 (Beilstein Handbook Reference)
20.alpha.-Hydroxypreg-4-en-3-one
NSC-68630
4-PREGNEN-20ALPHA-OL-3-ONE
4-PREGNEN-3-ONE-20.ALPHA.-OL
SMR000058614
PREGN-4-ENE-20.ALPHA.-OL-3-ONE
20.ALPHA.-HYDROXYPREGN-4-EN-3-ONE
PROGESTERONE IMPURITY B [EP IMPURITY]
20.ALPHA.-HYDROXYPROGESTERONE, (+)-
.DELTA.4-PREGNEN-20.ALPHA.-OL-3-ONE
.DELTA.4-PREGNENE-20.ALPHA.-OL-3-ONE
20.ALPHA.-HYDROXY-.DELTA.4-PREGNEN-3-ONE
20|A-dihydroprogesterone
PROGESTERONE IMPURITY B (EP IMPURITY)
4-PREGNEN-20-ALPHA-OL-3-ONE
20 alpha Dihydroprogesterone
20 alpha Hydroxyprogesterone
20 alpha-Dihydroprogesterone
20 alpha-Hydroxyprogesterone
Pregn-4-en-3-one, 20-alpha-hydroxy-
UNII-45630A64AC
Progesterol-20a
20a-Progerol
(8S,9S,10R,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
20alpha Hydroxypregn 4 Ene 3 One
20alpha-Hydroxypregn-4-Ene-3-One
20 alpha Hydroxy 4 Pregnen 3 One
20 alpha-Hydroxy-4-Pregnen-3-One
Progesterol-20alpha
Pregn 4 en 3 one, 20 alpha hydroxy
20a-Dihydroprogesterone
20a-Hydroxyprogesterone
20-a-Dihydroprogesterone
Opera_ID_1926
20a-Hydroxypregnen-2-one
20a-Hydroxydihydroprogesterone
SCHEMBL677417
20a-Hydroxypreg-4-en-3-one
?4-Pregnen-20?-ol-3-one
CHEMBL1583424
pregn-4-en-20(s)-ol-3-one
DTXSID10904767
20-Hydroxypregn-4-en-3-one #
(20S)-hydroxypregn-4-en-3-one
HMS2232D10
LMST02030169
MSK158521
20-alpha-hydroxy-Pregn-4-en-3-one
4-PREGNEN-3-ONE-20ALPHA-OL
20-.alpha.-Hydroxypregn-4-en-3-one
FP29553
PREGN-4-EN-20ALPHA-OL-3-ONE
NCGC00247054-01
PD213756
DELTA4-PREGNENE-20ALPHA-OL-3-ONE
20ALPHA-HYDROXYPROGESTERONE, (+)-
HY-113062
20.ALPHA.-HYDROXY-4-PREGNEN-3-ONE
NS00079448
Pregn-4-en-3-one, 20alpha-hydroxy-(8CI)
20ALPHA-HYDROXY-DELTA4-PREGNEN-3-ONE
C04042
G87780
Pregn-4-en-3-one, 20-hydroxy-, (20S)-(9CI)
Q28529678
E053C2FD-57C6-4220-8146-5C7437A4E7C2
205-649-5