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Cortisol

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
State
State

At room temperature, cortisol is a solid. It appears as a crystalline powder, which can be relatively stable under normal conditions, making it suitable for storage and handling in various applications.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
631.50
Boiling point (Kelvin)
904.65
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.1200g/cm3
Appearence

Cortisol is a white crystalline powder. It may appear slightly off-white or even colorless. The compound is typically seen in solid form and can be relatively powdery or granular depending on its form and purity.

Comment on solubility

Solubility of (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde (C21H30O5)

The solubility characteristics of this complex organic compound can be intriguing due to its multifaceted structure. Compounds with similar structures often exhibit solubility that varies significantly based on their functional groups and the polarity of their molecules. In this case, the presence of hydroxyl groups (-OH) and a carbonyl group (C=O) suggests the potential for hydrogen bonding, which enhances solubility in polar solvents such as water.

However, the overall hydrophobic nature of the hydrocarbon framework may hinder solubility in highly polar solvents. To better understand the compound's solubility, consider the following factors:

  • Polar vs. Non-Polar Solvents: The presence of hydrophilic groups may promote solubility in polar solvents, while the large hydrophobic core favors non-polar solvents.
  • Temperature: As a rule of thumb, solubility generally increases with temperature. Therefore, heating the solvent may help in dissolving the compound better.
  • pH Levels: Since this compound features acidic and basic functional groups, adjusting the pH can enhance its solubility profile.

In summary, while the solubility of (C21H30O5) may be influenced by its functional groups, considerable experimentation would be necessary to fully characterize its solubility behavior in various solvents. The interplay of the different structural components will ultimately dictate how readily this compound dissolves in solution.

Interesting facts

Interesting Facts about (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde

This complex organic compound exhibits intriguing structural and functional characteristics that make it a subject of interest in the field of chemistry and pharmacology. Below are some fascinating insights:

  • Natural Occurrence: This compound is closely related to certain natural steroid hormones and can be explored in various biological contexts.
  • Chemical Framework: The compound's backbone features multiple fused rings, a hallmark of many steroid-like structures, which greatly influences its biological activity.
  • Potential Applications: Due to its functional groups, this compound may exhibit properties useful in medicinal chemistry, particularly in the development of pharmaceuticals.
  • Chirality: With several chiral centers, this compound exists in multiple stereoisomeric forms. The specific stereochemistry can have significant implications for its bioactivity.
  • Reaction Pathways: Its structure allows for a myriad of possible transformations, making it an interesting subject for synthetic organic chemists.

As the renowned chemist Linus Pauling once stated, “The best way to have a good idea is to have a lot of ideas.” This compound certainly embodies this philosophy, as its complexity opens doors to various research avenues, promising exciting discoveries in the realms of biochemistry and pharmacology.

In summary, (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde is not just a compound of theoretical interest but also a potential key player in understanding and manipulating biological processes.

Synonyms
ALDOSTERONE
52-39-1
Electrocortin
Aldocortin
(+)-Aldosterone
Aldocorten
Aldocortene
Reichstein X
Elektrocortin
d-Aldosterone
18-Oxocorticosterone
Aldosteronum
Aldosterona
18-Aldocorticosterone
[3H]aldosterone
11beta,21-Dihydroxypregn-4-ene-3,18,20-trione
(11BETA)-11,21-DIHYDROXY-3,20-DIOXOPREGN-4-EN-18-AL
11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11b)-
11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione
11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al
NSC 73856
NSC-73856
Aldosterone (INN)
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
CHEBI:27584
11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al
4964P6T9RB
ALDOSTERONE [MI]
ALDOSTERONE [INN]
11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 18,11-halbacetal
ALDOSTERONE [MART.]
ALDOSTERONE [WHO-DD]
DTXSID7022419
NSC73856
11.beta.,21-Dihydroxypregn-4-ene-3,18,20-trione
Aldosteronum [INN-Latin]
Aldosterona [INN-Spanish]
ALDOSTERONE (MART.)
Aldosterone [INN:BAN:DCF]
[3H]-aldosterone
SMR000857170
EINECS 200-139-9
Aldosterone (Hemiacetal) (1.0mg/mL in Acetonitrile)
BRN 3224996
UNII-4964P6T9RB
delta-Aldosterone
(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo(8.7.0.02,7.011,15)heptadec-6-ene-15-carbaldehyde
(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadec-6-ene-15-carbaldehyde
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthrene-13-carbaldehyde
Aldosterone (Standard)
11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
Aldosterone 100 microg/mL in Acetonitrile
SCHEMBL1675
11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al
4-08-00-03491 (Beilstein Handbook Reference)
MLS001333163
MLS001333164
BIDD:ER0511
US10188667, Aldosterone
CHEMBL273453
DTXCID902419
GTPL2872
GTPL3452
Aldosterone, >=95% (HPLC)
BDBM19214
(11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al
HMS2233D14
LMST02030026
MFCD00051136
AKOS024462706
DB04630
FA17269
HY-113313R
NCGC00164236-01
AS-69489
HY-113313
CS-0059576
NS00014784
C01780
D10528
Q184564
SR-01000838883
SR-01000838883-2
11-beta,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al
(11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al
11-beta-18-Epoxy-18,21-dihydroxypregn-4-ene-3,20-dione
Pregn-4-en-18-al,21-dihydroxy-3,20-dioxo-, (11.beta.)-
Pregn-4-ene-3,20-dione, 11-beta,18-epoxy-18,21-dihydroxy-
Pregn-4-ene-3,20-dione, 11beta,18-epoxy-18,21-dihydroxy-
(11alpha,14beta,17alpha)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al
Pregn-4-ene-3,20-dione, 11,18-epoxy-18,21-dihydroxy-, (11-beta)-
11,13-(Epoxymethano)-13H-cyclopenta(a)phenanthrene, pregn-4-ene-3,20-deriv.
(11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al;11b,21-Dihydroxypregn-4-ene-3,18,20-trione;18-Formyl-11b,21-dihydroxy-4-pregnene-3, 20-dione
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,3,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-13H-cyclopenta[a]phenanthrene-13-carbaldehyde
11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
200-139-9