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Testosterone

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Identification
Molecular formula
C19H28O2
CAS number
58-22-0
IUPAC name
(8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, testosterone is a solid compound. It is relatively stable and does not evaporate easily, being a crystalline substance at standard conditions.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
413.00
Boiling point (Kelvin)
686.15
General information
Molecular weight
288.43g/mol
Molar mass
288.4240g/mol
Density
1.1180g/cm3
Appearence

Testosterone appears as a white to practically white crystalline powder or white crystals. It is often found in its esterified forms, such as testosterone enanthate, characterized by its slightly different physical appearance when in crystalline form.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one (C19H28O2)

The solubility characteristics of the compound (8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one (C19H28O2) can present both unique challenges and opportunities for understanding its interaction with solvents.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups typically enhances solubility in polar solvents such as water.
  • Hydrophobic Regions: The aliphatic and cyclic hydrocarbon components of the molecule may lead to significant hydrophobic interactions, affecting overall solubility in non-polar solvents.
  • Temperature: Increased temperature generally increases solubility for many organic compounds, making it essential to consider thermal effects in practical applications.

Due to the compound's complex structure, one might expect variable solubility ranges:

  • It may be moderately soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • However, solubility in water may be limited despite the presence of the hydroxyl group, suggesting a nuanced balance between polar and non-polar characteristics.

In summary, understanding the solubility of C19H28O2 is critical for its practical applications in fields such as pharmacology, where its interactions with solvents can impact bioavailability and efficacy.

Interesting facts

Interesting Facts about (8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This compound, a member of the steroid family, showcases a complex molecular structure with significant biological relevance. Here are some fascinating insights:

  • Biological Activity: Many compounds with a similar steroidal structure play vital roles in biological systems, including acting as hormones that influence various physiological processes.
  • Stereochemistry: The stereochemistry of this compound, indicated by its detailed labeling of chiral centers, is crucial for understanding its interactions and efficacy in biological systems. The specific conformation can dictate how the compound binds to receptors.
  • Potential Applications: Research surrounding analogs of this compound suggests potential therapeutic uses, particularly in areas such as hormone replacement therapies and anti-inflammatory treatments.
  • Synthesis Challenges: The synthesis of such complex molecules often involves multi-step organic reactions that can be challenging, making this compound a subject of interest for organic chemists.
  • Natural Occurrence: Compounds like this one are often found in nature, emphasizing the importance of understanding their sources and the ecological roles they may play within biological systems.

In the words of renowned chemist Richard Feynman, “What I cannot create, I do not understand.” Studying this compound and its derivatives allows chemists to grasp not only the intricacies of its structure but also its contributions to both health and disease.

Overall, the exploration of its properties and potential applications continues to be a stimulating area of research in the field of medicinal chemistry.

Synonyms
NORETHANDROLONE
Pronabol
Nilevar
Solevar
52-78-8
Noretandrolona
17-Ethyl-19-nortestosterone
Ethylnortestosteron
17-ENT
Noretandrolone
Nileva
Norethandrolonum
Noretandrolone [DCIT]
19-Norethyltestosterone
17-alpha-Nortestosterone
19-Nortestosterone, 17-ethyl-
SC 5914
17alpha-Ethylnortestosterone
Noretandrolona [INN-Spanish]
Norethandrolonum [INN-Latin]
NSC 70581
CCRIS 9066
CB 8022
17alpha-Ethyl-19-nortestosterone
19-Nor-17-alpha-ethyltestosterone
EINECS 200-153-5
NSC-70581
U 6817
17-Hydroxy-19-norpregn-4-en-3-one
Norethandrolone [INN:BAN:NF]
17-alpha-Ethyl-17-hydroxynorandrostenone
UNII-P7W01638W6
Norethandrolone (INN)
8022 C. B.
Estr-4-en-3-one, 17alpha-ethyl-17-hydroxy-
17-alpha-Ethyl-17-hydroxy-4-norandrosten-3-one
17-Hydroxy-19-nor-17-alpha-pregn-4-en-3-one
P7W01638W6
NORETHANDROLONE [MI]
NORETHANDROLONE [INN]
17-alpha-Ethyl-17-hydroxy-19-norandrost-4-en-3-one
19-Norpregn-4-en-3-one, 17-hydroxy-, (17alpha)-
8022 C.B.
17.alpha.-Ethylnortestosterone
NORETHANDROLONE [MART.]
(8R,9S,10R,13S,14S,17S)-17-ethyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
DTXSID0023379
NORETHANDROLONE [WHO-DD]
17alpha-Ethyl-17beta-hydroxyestr-4-en-3-one
19-Nor-17alpha-pregn-4-en-3-one, 17-hydroxy-
19-Nor-17-alpha-pregn-4-en-3-one, 17-hydroxy-
17.alpha.-Ethyl-19-nortestosterone
19-Norpregn-4-en-3-one, 17-hydroxy-, (17-alpha)-
(17-alpha)-17-Hydroxy-19-norpregn-4-en-3-one
17-.alpha.-Nortestosterone
Estr-4-en-3-one, 17.alpha.-ethyl-17-hydroxy-
Noretandrolona (INN-Spanish)
Norethandrolonum (INN-Latin)
17.alpha.-Ethyl-17.beta.-hydroxyestr-4-en-3-one
19-Nor-17.alpha.-pregn-4-en-3-one, 17-hydroxy-
NORETHANDROLONE (MART.)
Ethylestrenolone
19-Nor-17-.alpha.-ethyltestosterone
Norethandrolone (1mg/ml in Acetonitrile)
17-.alpha.-Ethyl-17-hydroxynorandrostenone
19-Norpregn-4-en-3-one, (17.alpha.)-
17-.alpha.-Ethyl-17-hydroxy-4-norandrosten-3-one
17-Hydroxy-19-nor-17-.alpha.-pregn-4-en-3-one
Norethandrolone (1.0 mg/mL in 1,2-Dimethoxyethane)
17-.alpha.-Ethyl-17-hydroxy-19-norandrost-4-en-3-one
19-Norpregn-4-en-3-one, 17-hydroxy-, (17.alpha.)-
17-.beta.-Hydroxy-19-nor-17-.alpha.-pregn-4-en-3-one
(1S,2R,10R,11S,14S,15S)-14-ethyl-14-hydroxy-15-methyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-5-one
(1S,2R,10R,11S,14S,15S)-14-ethyl-14-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
(17beta)-17-ethyl-17-hydroxyestr-4-en-3-one
SCHEMBL147638
DTXCID603379
CHEMBL1697845
A14AA09
NSC9893
CHEBI:135282
NSC-9893
NSC70581
DB12787
Norethandrolone 1.0 mg/ml in Acetonitrile
17alpha-Ethyl-17-hydroxyestr-4-en-3-one
NS00000172
D07127
Q7050955
17-beta-Hydroxy-19-nor-17-alpha-pregn-4-en-3-one
19-Nor-17alpha-pregn-4-en-3-one, 17-hydroxy-(8CI)
19-Norpregn-4-en-3-one, 17-hydroxy-, (17-alpha)-(9CI)
200-153-5