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Progesterone

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Identification
Molecular formula
C21H30O2
CAS number
57-83-0
IUPAC name
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, Progesterone is in a solid state, typically appearing as a crystalline powder. It is not particularly volatile and remains stable under normal environmental conditions.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
215.00
Boiling point (Kelvin)
488.15
General information
Molecular weight
314.47g/mol
Molar mass
314.4660g/mol
Density
1.1660g/cm3
Appearence

Progesterone appears as a white to off-white crystalline powder. It is odorless and has an inert visual presence. The compound is typically used in pharmacological formulations and may be suspended in aqueous solutions or encapsulated in various forms.

Comment on solubility

Solubility of (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The compound with the chemical formula C21H30O2 exhibits noteworthy solubility characteristics due to its unique structural features. Understanding these properties can reveal important insights into its potential applications in various fields.

Factors Influencing Solubility

The solubility of this compound can be affected by several factors, including:

  • Polarity: The presence of hydroxyl groups contributes to its polar nature, often enhancing solubility in polar solvents such as water and alcohol.
  • Molecular Size: Due to its relatively large molecular size, solubility might decrease in small, non-polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly improve solubility in suitable solvents.

Solubility Behavior

In general, one might expect the solubility of the compound to be:

  • Highly soluble in organic solvents like ethanol, methanol, and acetone due to its hydrophobic carbon structure.
  • Moderately soluble in aqueous solutions because of the hydrophilic alcohol (−OH) group, allowing for some degree of interaction with water.

Ultimately, the compound's solubility is a complex interplay of its structural components, leading to a variety of interactions with potential solvents. As with many organic compounds, the solubility could play a critical role in determining its effectiveness and usability in practical applications.

Interesting facts

Interesting Facts about (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This compound, often encountered in discussions of steroid derivatives, showcases the intricate balance between structure and functionality. Here are some engaging insights:

  • Steroidal Framework: This compound belongs to the steroid family, characterized by a core structure of four fused carbon rings. The complexity of its structure, with multiple chiral centers, highlights the significance of stereochemistry in biological activity.
  • Functional Groups: The presence of both acetyl and hydroxy groups contributes to its unique properties. These functional groups are crucial for the compound's reactivity and biological interactions.
  • Medical Relevance: Steroid compounds are widely researched for their potential therapeutic effects, including anti-inflammatory and anabolic effects, making derivatives like this one essential in pharmacology.
  • Biological Pathways: Understanding how compounds like this one interact within biological pathways can unveil insights into hormone regulation, potentially leading to novel treatments for endocrine system disorders.

As a chemistry student or enthusiast, it's fascinating to explore how such specialized compounds are synthesized and their implications in both industry and health. The intricate design of this molecule reflects the beauty and complexity of organic chemistry, emphasizing the importance of understanding both structure and function in medicinal chemistry.

"In every molecule, there lies a story waiting to be uncovered." Delving into the structural nuances of such compounds opens doors to understanding the chemical elegance that governs life itself.

Synonyms
hydroxyprogesterone
17ALPHA-HYDROXYPROGESTERONE
68-96-2
17-Hydroxyprogesterone
17a-Hydroxyprogesterone
Prodix
Prodox
Gestageno gador
17-alpha-Hydroxyprogesterone
Setaderm
Oxiprogesteronum
Pregn-4-ene-3,20-dione, 17-hydroxy-
17-Hydroxypregn-4-ene-3,20-dione
Hidroxiprogesterona
Hydroxyprogesteronum
17alpha-Hydroxy-4-pregnene-3,20-dione
17alpha-Hydroxy-progesterone
17|A-Hydroxyprogesterone
Pregn-4-ene-3,20-dione-17-ol
delta(4)-Pregnene-17alpha-ol-3,20-dione
Gestageno
Idrossiprogesterone [DCIT]
17-OH Progesterone
17-Hydroxypregn-4-en-3,20-dione
alpha Hydroxy progesterone
HSDB 3343
Hydroxyprogesteronum [INN-Latin]
Hidroxiprogesterona [INN-Spanish]
17OHP
17.alpha.-Hydroxyprogesterone
CHEBI:17252
604-09-1
17alpha hydroxyprogesterone
EINECS 200-699-4
NSC 15468
NSC-15468
BRN 2062088
DTXSID6040747
UNII-21807M87J2
U 3096
MLS000028453
MLS001076300
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
21807M87J2
DTXCID4020747
4-Pregnen-17a-ol-3,20-dione
U-3096
4-08-00-02189 (Beilstein Handbook Reference)
Delta4-Pregnen-17alpha-ol-3,20-dione
NCGC00093949-03
alpha-17Hydroxypregn-4-ene-3,20-dione
SMR000058349
Hydroxyprogesterone (INN)
(9beta)-17-Hydroxypregn-4-Ene-3,20-Dione
HYDROXYPROGESTERONE [INN]
Hydroxyprogesteronum (INN-Latin)
Hidroxiprogesterona (INN-Spanish)
MFCD00003659
Idrossiprogesterone
CAS-68-96-2
17alpha-Hydroxypregn-4-ene-3,20-dione
Hydroxyprogesterone [INN:BAN]
17 Hydroxyprogesterone
17Alpha-hydroxy progesterone
17 alpha Hydroxyprogesterone
17 alpha-Hydroxyprogesterone
3QZ
Pregn-4-ene-3,20-dione, 17-hydroxy-, (17a)-
17-Hydroxyprogeoterone
17-alpha-Hydroxypregn-4-ene-3,20-dione
17-hydroxy-progesterone
17?-Hydroxyprogesterone
17a-hydroxy progesterone
17-a-Hydroxyprogesterone
17-Hydroxyprogesterone, (17 alpha)-Isomer
Opera_ID_1812
17?-Hydroxy Progesterone
bmse000472
bmse000598
Epitope ID:152220
17|A-Hydroxy Progesterone
SCHEMBL8068
CHEMBL1062
BIDD:PXR0103
Lopac0_000565
17.alpha.-Hydoxyprogesterone
MLS002695950
17-OHP
GTPL5104
Progesterone, 17alpha-hydroxy-
Pregn-4-ene-3,20-dione, 17-hydroxy-, (17.alpha.)-
HY-B0891R
Pregn-4-ene-3, 17-hydroxy-
DTXSID00859075
HYDROXYPROGESTERONE [HSDB]
MSK8516
HMS2090M08
HMS2234J04
HMS3261B12
HYDROXYPROGESTERONE [VANDF]
D4-Pregnen-17a-ol-3,20-dione
HY-B0891
NSC15468
Pregn-4-en-17a-ol-3,20-dione
HYDROXYPROGESTERONE [WHO-DD]
Tox21_111233
Tox21_301530
Tox21_500565
17|A-Hydroxyprogesterone (Standard)
BDBM50423511
LMST02030161
s4507
17alpha-Hydroxyprogesterone, >=95%
17a-Hydroxypregn-4-ene-3,20-dione
AKOS015955623
Tox21_111233_1
CCG-204655
CS-4354
DB14570
FD12004
FH24103
KS-5312
LP00565
SDCCGSBI-0050548.P002
4-Pregnen-17.alpha.-ol-3,20-dione
NCGC00093949-04
NCGC00093949-05
NCGC00093949-08
NCGC00255425-01
NCGC00261250-01
17alpha-hydroxy-pregn-4-ene-3,20-dione
17.ALPHA.-HYDROXYPROGESTERONE [MI]
17.alpha.-Hydroxypregna-4-ene-3,20-dione
EU-0100565
H1250
NS00115894
C01176
D08052
H 5752
17-Hydroxypregn-4-ene-3,20-dione, (+/-)-
AB00490003-08
17-Alpha-Hydroxyprogesterone, 1mg/ml in Methanol
Q175901
17.ALPHA.-HYDROXYPREGN-4-ENE-3,20-DIONE
17-Hydroxypregn-4-ene-3,20-dione-, (17.alpha.)-
7A45BEF6-ADD0-4B3E-A014-2DE930D3B67B
17alpha-Hydroxyprogesterone, VETRANAL(TM), analytical standard
17-Hydroxy-pregn-4-ene-3,20-dione;4-Pregnen-17a-ol-3,20-dione
(1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
(8R,10R,13S,17R)-17-Acetyl-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
110850-01-6
200-699-4