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Vorinostat

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Identification
Molecular formula
C14H20N2O3
CAS number
149647-78-9
IUPAC name
8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid
State
State

At room temperature, Vorinostat is in a solid state. It is stable under normal ambient and anticipated storage conditions of pressure and temperature.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.20
Boiling point (Celsius)
515.50
Boiling point (Kelvin)
788.70
General information
Molecular weight
264.32g/mol
Molar mass
264.3230g/mol
Density
1.1180g/cm3
Appearence

Vorinostat appears as a white to light yellow crystalline powder. It is relatively odorless and has a slight hygroscopic nature, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid

The solubility of 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid (C14H20N2O3) presents notable characteristics influenced by its structural components. Understanding solubility factors is essential for potential applications and formulations. Here are some key points to consider:

  • Polarity: The compound contains hydroxamic acid functionality, which typically enhances solubility in polar solvents due to hydrogen bonding capabilities.
  • Aromatic Groups: The presence of aromatic systems such as phenyl and piperazine can affect solubility. These groups generally increase hydrophobic interactions, potentially reducing solubility in water.
  • Solvent Compatibility: Solubility may vary significantly between solvents. The compound is more likely to dissolve in organic solvents like ethanol or DMSO, than in aqueous solutions.
  • Temperature Influence: An increase in temperature may improve the solubility of the compound in certain solvents, as higher kinetic energy often facilitates dissolution.

In conclusion, while 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid exhibits properties that suggest it may have moderate solubility in polar solvents, its precise solubility profile will ultimately depend on the specific solvent used and the conditions under which solubility is measured. As with many complex organic compounds, empirical testing remains critical for accurate assessments.

Interesting facts

Interesting Facts About 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic Acid

8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid is a fascinating compound in the realm of medicinal chemistry and pharmacology. This compound is particularly noteworthy for its potential applications in the treatment of a range of diseases, including neurological disorders.

Key Highlights:

  • Neuropharmacological Potential: The structural features of this compound suggest that it can interact with key neurotransmitter systems, possibly making it a candidate for drugs targeting anxiety, depression, and other mood disorders.
  • Oxime Functionality: The hydroxamic acid moiety in 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid is known for its ability to chelate metal ions, which can be crucial in biochemical pathways. This property has applications in drug design and understanding enzyme mechanisms.
  • Structural Complexity: The presence of both the piperazine and phenyl groups contributes to the compound's lipophilicity, enhancing its membrane permeability, which is vital for its efficacy as a therapeutic agent.
  • Research Opportunities: As a relatively novel compound, it presents a variety of research avenues, from synthesis challenges to biological assays, allowing future scientists to explore its full potential.

In summary, 8-oxo-8-[4-(4-phenylpiperazin-1-yl)phenyl]octanehydroxamic acid embodies a blend of chemical elegance and therapeutic promise. As we continue to delve deeper into its properties, we may uncover new insights that could lead to groundbreaking treatments in modern medicine.

Synonyms
CHEMBL99216
HDInhib_000027
SCHEMBL3384299
BDBM50114811
N-hydroxy-8-oxo-8-(4-(4-phenylpiperazin-1-yl)phenyl)octanamide
8-Oxo-8-[4-(4-phenyl-piperazin-1-yl)-phenyl]-octanoic acid hydroxyamide