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Tropine

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Identification
Molecular formula
C8H15NO
CAS number
120-29-6
IUPAC name
8-methyl-8-azabicyclo[3.2.1]octan-3-ol
State
State

At room temperature, tropine is a solid. The solid form is stable under standard conditions, but it is hygroscopic and can become more viscous upon exposure to moisture.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.15
Boiling point (Celsius)
233.50
Boiling point (Kelvin)
506.65
General information
Molecular weight
141.22g/mol
Molar mass
141.2160g/mol
Density
1.0205g/cm3
Appearence

Tropine appears as a colorless crystalline solid. It has a slightly glossy texture and can absorb moisture from the air, making it hygroscopic. It typically forms small, needle-like crystals.

Comment on solubility

Solubility of 8-methyl-8-azabicyclo[3.2.1]octan-3-ol

The solubility of 8-methyl-8-azabicyclo[3.2.1]octan-3-ol can vary significantly depending on the solvent used and environmental conditions. Here are some key points to consider:

  • Polar Solvents: This compound is expected to have better solubility in polar solvents such as water or alcohol due to the presence of hydroxyl (-OH) groups that facilitate hydrogen bonding.
  • Non-Polar Solvents: The solubility in non-polar solvents like hexane may be limited due to the compound's structural characteristics that make it less favorable for dissolution in non-polar environments.
  • pH Sensitivity: The solubility can also be influenced by pH levels, especially if the compound ionizes under certain conditions, impacting its overall solubility behavior.
  • Temperature Effects: Like many organic compounds, increasing temperature typically leads to increased solubility, which might be relevant when considering its applications.

In conclusion, the solubility of 8-methyl-8-azabicyclo[3.2.1]octan-3-ol is complex and affected by multiple factors, making it essential to consider the specific conditions when predicting its behavior in various environments.

Interesting facts

Interesting Facts About 8-methyl-8-azabicyclo[3.2.1]octan-3-ol

8-methyl-8-azabicyclo[3.2.1]octan-3-ol is an intriguing compound in the realm of organic chemistry, particularly due to its unique bicyclic structure and its relation to various physiological activities. Here are some fascinating points about this compound:

  • Structural Uniqueness: The bicyclic structure of this compound provides a compact and complex arrangement of atoms, which can lead to distinctive chemical properties compared to linear or simpler cyclic compounds.
  • Pharmacological Relevance: Molecules with similar structures have exhibited potential pharmacological activities. They are often studied for their implications in the development of new medications, particularly in the field of neuropharmacology.
  • Derivatives and Applications: The modifications of 8-methyl-8-azabicyclo[3.2.1]octan-3-ol can yield various derivatives, each with unique biological and chemical characteristics, showcasing the compound's versatility in medicinal chemistry.
  • Chirality: This compound displays chirality due to the presence of asymmetrical centers; chirality is a critical aspect in biochemistry, especially regarding the interaction of drugs with biological systems.
  • Research Potential: Ongoing research into the derivatives of this compound continues to unveil possibilities for new therapeutic agents, thereby highlighting its importance in medicinal chemistry.

In summary, 8-methyl-8-azabicyclo[3.2.1]octan-3-ol serves as a noteworthy example of how complex organic structures can lead to significant implications in both scientific research and practical applications. As one explores the depths of chemistry, compounds like this one remind us of the intricate relationships between molecular structure and biological function.

Synonyms
Tropine
8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
3-Tropanol
120-29-6
7432-10-2
Tropanol
3alpha-Tropanol
3.alpha.-Tropanol
NSC43870
NSC43871
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, endo-
8-Azabicyclo(3.2.1)octanol, 8-methyl-
2,3-Dihydro-3.alpha.-hydroxytropidine
1.alpha.H,5.alpha.H-Tropan-3.alpha.-ol
2,3-Dihydro-3alpha-hydroxytropidine
NSC 43870
1-Methyl-2,5-(2-hydroxytrimethylene)pyrrolidine
3.beta.-Tropanol
1-alpha-H,5-alpha-H-Tropan-3-alpha-ol
8-Azabicyclo[3.2.1]octanol, 8-methyl-
N-Tropine (trans)
b-Tropine
NSC-43870
NSC-43871
tropan-3-ol
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, exo-
Prestwick0_001077
Prestwick1_001077
Prestwick2_001077
Prestwick3_001077
bmse000974
Oprea1_099397
SCHEMBL38978
BSPBio_001094
rel-(1R,3s,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
SPBio_002997
BPBio1_001204
CHEMBL113555
DTXSID70859224
HMS1571G16
HMS1661L14
HMS2098G16
HY-N7061
NSC241183
STL377773
AKOS005267127
AKOS015955557
AC-1979
AC-1980
CCG-208541
CS-W016435
FT28616
NSC-241183
NCGC00179307-01
AS-13524
AS-13829
SY005218
1alphaH,5alphaH-Tropan-3alpha-ol (8CI)
DB-220048
N-Methyl-8-azabicyclo[3.2.1]octan-3-ol
8-Methyl-8-aza-bicyclo[3.2.1]octan-3-ol
8-Methyl-8-azabicyclo[3.2.1]octan-3-ol;
AB00514033
CS-0369298
C00729
C02066
EN300-223936
2,3-Dihydro-3alpha-hydroxy-8-methylnortropidine
8-Methyl-8-azabicyclo[3.2.1]octan-3-ol, endo-
endo-8-Azabicyclo[3.2.1]-3-octanol, 8-methyl-
SR-05000002205
SR-05000002205-2
F0001-2567
0AC9FE9A-C292-490C-A504-EA261C257333
2,3-Dihydro-3?-hydroxytropidine;2,3-Dihydro-3?-hydroxy-8-methylnortropidine
InChI=1/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H