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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
8-methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine
State
State

At room temperature, Clozapine is commonly found in its solid state.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.00
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.00
General information
Molecular weight
327.83g/mol
Molar mass
326.8320g/mol
Density
1.2900g/cm3
Appearence

Clozapine typically appears as a pale yellow to yellow crystalline powder.

Comment on solubility

Solubility of 8-methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine

The solubility of 8-methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine, with the chemical formula C18H19ClN4, can be affected by several factors. Understanding these factors is crucial for predicting how this compound will behave in different environments.

Factors Influencing Solubility

  • Polarity: The compound's structure contains various polar and nonpolar regions which can influence its solubility in different solvents.
  • Temperature: Typically, as temperature increases, solubility also increases, but this rule has exceptions depending on the specific interactions in the solution.
  • pH: The ionization state of the compound can change with pH, impacting its solubility in water or organic solvents.

It’s also important to note that:

  • The solubility might be higher in organic solvents, which can better accommodate the nonpolar portions of the molecule.
  • As a benzodiazepine derivative, its solubility could be influenced by typical characteristics associated with similar compounds, such as the presence of nitrogen heteroatoms and ring structures.

In summary, while the solubility of this complex compound may not be straightforward, the interaction of its unique structural elements with various solvents will ultimately dictate its solubility behavior. To truly understand its solubility, experimental measurements in different conditions will provide the most reliable insights.

Interesting facts

Interesting Facts about 8-Methyl-6-(4-methylpiperazin-1-yl)-11H-pyrido[2,3-b][1,4]benzodiazepine

This compound, often referred to in the realm of medicinal chemistry, belongs to a unique class known as benzodiazepines, which are well-regarded in pharmacology for their potential therapeutic applications. Here are some noteworthy points about this fascinating compound:

  • Pharmacological Interest: Compounds of this class have shown promise in treating a variety of conditions including anxiety disorders, insomnia, and seizure disorders due to their central nervous system depressant properties.
  • Molecular Diversity: The structure of this compound combines a complex bicyclic system with piperazine functionality, which allows for diverse interactions at biological targets, potentially impacting receptor affinities in innovative ways.
  • Synthesis and Reactions: The preparation of this compound involves intricate synthetic pathways, which are of significant interest to organic chemists. It often showcases the use of multidimensional synthesis techniques, highlighting the challenge of assembling its complex architecture efficiently.
  • Research Potential: Studies suggest that derivatives of this compound could provide leads for developing new antidepressants or anxiolytic agents, expanding the arsenal available for mental health treatments.
  • Interdisciplinary Nature: Insights into the efficacy and mechanism of action of this compound require a blend of knowledge from medicinal chemistry, pharmacology, and toxicology, reflecting the interdisciplinary nature of current pharmaceutical research.

In summary, the therapeutic potential of this compound, combined with its intricate molecular design, makes it a subject of ongoing interest in both academic and pharmaceutical research settings. As we continue to unravel the complexities of such compounds, the future of medicinal chemistry holds exciting possibilities!

Synonyms
JL-18
147395-65-1
JL 18
8-methyl-6-(4-methylpiperazin-1-yl)-11h-pyrido[2,3-b][1,4]benzodiazepine
8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido(2,3-b)(1,4)benzodiazepine
NCGC00094013-01
CHEMBL63329
8-methyl-6-(4-methyl-1-piperazinyl)-11h-pyrido[2,3-b][1,4]benzodiazepine
Lopac-J-102
11H-Pyrido[2,3-b][1,4]benzodiazepine,8-methyl-6-(4-methyl-1-piperazinyl)-
2TT8RV9JY8
Lopac0_000646
SCHEMBL4358144
DTXSID70163696
HMS3262A13
Tox21_500646
BDBM50040245
AKOS040752182
CCG-204733
LP00646
SDCCGSBI-0050626.P002
NCGC00015574-01
NCGC00015574-02
NCGC00015574-03
NCGC00015574-04
NCGC00094013-02
NCGC00261331-01
EU-0100646
J-102
SR-01000075386
SR-01000075386-1
11H-Pyrido[2,3-b][1,4]benzodiazepine, 8-methyl-6-(4-methyl-1-piperazinyl)-
8-Methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,4]benzeodiazepine
8-Methyl-6-(4-methyl-piperazin-1-yl)-11H-benzo[e]pyrido[3,2-b][1,4]diazepine