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8-Hydroxyeicosatetraenoic acid

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Identification
Molecular formula
C20H32O3
CAS number
10078-60-5
IUPAC name
8-hydroxyicosa-5,9,11,14-tetraenoic acid
State
State

At room temperature, 8-Hydroxyeicosatetraenoic acid is generally observed as a liquid. It is often stored under conditions that prevent oxidation, due to its unsaturated bonds, which make it sensitive to air and light.

Melting point (Celsius)
-30.00
Melting point (Kelvin)
243.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
320.48g/mol
Molar mass
320.4820g/mol
Density
0.9500g/cm3
Appearence

8-Hydroxyeicosatetraenoic acid is typically a colorless to pale yellow oily liquid. It may also appear as a viscous solution when in pure form. Its appearance can vary slightly based on purity and concentration in mixtures.

Comment on solubility

Solubility of 8-hydroxyicosa-5,9,11,14-tetraenoic acid (C20H32O3)

8-hydroxyicosa-5,9,11,14-tetraenoic acid, often abbreviated as its structural formula, presents interesting characteristics concerning its solubility.

General Solubility Trends

When considering the solubility of this compound, it is essential to note the following:

  • Polar and Nonpolar Regions: The presence of the hydroxyl group (-OH) in the structure increases its polarity, potentially enhancing solubility in polar solvents such as water.
  • Hydrophobic Character: However, with a long hydrocarbon chain, there is also a significant hydrophobic character, which suggests limited solubility in water.
  • Solvent Compatibility: Due to its mixed characteristics, it may be more soluble in organic solvents such as ethanol or chloroform.

Factors Influencing Solubility

The solubility behavior of 8-hydroxyicosa-5,9,11,14-tetraenoic acid can also be influenced by:

  • Temperature: Increasing temperature generally leads to increased solubility in most compounds, and this may hold true for 8-hydroxyicosa-5,9,11,14-tetraenoic acid as well.
  • pH Levels: The ionization of the -OH group at various pH levels might impact its solubility, particularly in aqueous solutions.
  • Presence of Other Solutes: The interactions with other solutes can either enhance or diminish solubility through various solvation effects.

In summary, while 8-hydroxyicosa-5,9,11,14-tetraenoic acid shows the potential for solubility in polar solvents due to its hydroxyl group, the overarching hydrophobic characteristics from its lengthy carbon chain can lead to limited solubility in water. Therefore, understanding the balance of its polar and nonpolar regions is key to predicting its solubility behavior.

Interesting facts

Interesting Facts About 8-Hydroxyicosa-5,9,11,14-tetraenoic Acid

8-Hydroxyicosa-5,9,11,14-tetraenoic acid, commonly referred to as a specific type of hydroxy fatty acid, belongs to a class of compounds that play significant roles in various biological processes. Here are some fascinating aspects of this compound:

  • Biosynthesis: This compound is a derivative of arachidonic acid and is involved in the metabolism of polyunsaturated fatty acids within the body. It showcases the intricate pathways of lipid metabolism.
  • Biological Activity: Research indicates that hydroxy fatty acids, including this one, have potential anti-inflammatory properties, making them of interest in studying various inflammatory diseases.
  • Signaling Molecule: 8-Hydroxyicosa-5,9,11,14-tetraenoic acid can act as a signaling molecule in cells, influencing a wide range of physiological processes. This is vital in understanding cell communication and function.
  • Dietary Significance: Compounds of this nature are often found in various dietary sources, particularly in fish oils, exemplifying the importance of nutrition in health.
  • Research Implications: Scientists are engaged in ongoing studies to further uncover the roles of hydroxy fatty acids in health and disease, indicating their importance in future therapeutic approaches.

In summary, 8-hydroxyicosa-5,9,11,14-tetraenoic acid is an intriguing compound that illustrates the connection between diet, metabolism, and potential health benefits. As research continues to evolve, the understanding of its mechanisms and applications in medicine may pave the way for innovative treatments and enhanced health strategies.

Synonyms
8-hydroxyicosa-5,9,11,14-tetraenoic acid
105500-09-2
HETE-8(R )
(+/-)8-HETE
8-hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid
DTXSID80869319
EDA49584
YDA46203