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8-(hydroxyamino)-8-oxo-N-phenyl-octanamide

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Identification
Molecular formula
C14H20N2O3
CAS number
73631-72-6
IUPAC name
8-(hydroxyamino)-8-oxo-N-phenyl-octanamide
State
State
At room temperature, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide is generally encountered as a solid.
Melting point (Celsius)
102.50
Melting point (Kelvin)
375.70
Boiling point (Celsius)
510.50
Boiling point (Kelvin)
783.70
General information
Molecular weight
306.35g/mol
Molar mass
306.3520g/mol
Density
1.2145g/cm3
Appearence

8-(hydroxyamino)-8-oxo-N-phenyl-octanamide typically appears as a white to off-white solid. It is often encountered as a crystalline powder.

Comment on solubility

Solubility of 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide (C14H20N2O3)

The solubility of 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide can be quite interesting due to its complex molecular structure. This compound exhibits a noteworthy degree of versatility when it comes to solubility:

  • Polar Nature: The presence of hydroxyl (–OH) and amino (–NH2) groups typically enhances its solubility in polar solvents. This suggests that it may dissolve effectively in water and alcohols.
  • Hydrophobic Chain: However, the octanamide chain of the compound introduces a hydrophobic character that could cause limited solubility in highly polar solvents.
  • Solubility Range: It is likely to be soluble in:
    • Water (to some extent, influenced by temperature)
    • Organic solvents such as ethanol and methanol

In summary, while the hydrophilic functional groups may promote solubility, the overall hydrophobic nature of the octanamide segment could lead to variations in solubility depending on the solvent environment. This dual character is pivotal in determining the application and reactivity of the compound. As such, “the solubility of this compound can be described as moderate in polar solvents, reflecting the balance between its hydrophilic and hydrophobic components.”

Interesting facts

Interesting Facts about 8-(Hydroxyamino)-8-oxo-N-phenyl-octanamide

8-(Hydroxyamino)-8-oxo-N-phenyl-octanamide is a fascinating compound with intriguing potential in various fields of chemistry and biology. Known for its structural complexity, this compound features both a hydroxyamino group and an octanamide chain, which contributes to its unique chemical properties.

Key Characteristics:

  • Bioactivity: This compound is often examined for its biological activity, particularly in medicinal chemistry, where similar structures have shown promising results as therapeutic agents.
  • Synthesis: The synthesis of 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide is often a focal point for organic chemists, as it involves multiple reaction steps that can provide insight into reaction mechanisms and methodologies.
  • Applications: Due to its structural features, this compound may be investigated for applications in drug development, especially within the realms of anti-inflammatory and antimicrobial treatments.
  • Research Frontiers: Ongoing research into compounds like this one sheds light on how small changes in molecular structure can significantly influence activity and interactions at the cellular level.

As noted by chemists, "Understanding the nuances of molecular interactions allows scientists to pioneer new therapeutic strategies." The pursuit of knowledge surrounding compounds such as 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide can lead to breakthroughs in pharmacology and fine-tune our understanding of how organic molecules can affect biological systems.

In conclusion, 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide stands out not only for its chemical structure but also for the myriad possibilities it holds for future scientific advancements.

Synonyms
Vorinostat
149647-78-9
SAHA
suberoylanilide hydroxamic acid
N-hydroxy-N'-phenyloctanediamide
Zolinza
N1-hydroxy-N8-phenyloctanediamide
Suberanilohydroxamic acid
MK-0683
MK0683
SAHA cpd
Vorinostat [USAN]
Octanediamide, N-hydroxy-N'-phenyl-
Vorinostat (SAHA, MK0683)
N'-hydroxy-N-phenyloctanediamide
OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
CCRIS 8456
Zolinza (TN)
vorinostatum
NSC-701852
N-Hyrdroxy-N'-phenyloctanediamide
Vorinostat [USAN:INN]
MFCD00945317
NSC-748799
NSC-759852
Vorinostat (SAHA)
58IFB293JI
DTXSID6041133
SHH
CHEBI:45716
HSDB 7930
C14H20N2O3
VORINOSTAT [MI]
CHEMBL98
VORINOSTAT [INN]
VORINOSTAT [JAN]
NSC701852
VORINOSTAT [VANDF]
VORINOSTAT [MART.]
VORINOSTAT [WHO-DD]
DTXCID4021133
VORINOSTAT [ORANGE BOOK]
WIN64652
NSC 701852
NSC 748799
NSC 759852
NCGC00168085-01
NCGC00168085-02
Zolinza (TN) (Merck)
VORINOSTAT (MART.)
N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide
NHNPODA
Vorinostat MSD
SMR000486344
CAS-149647-78-9
SR-05000000373
Vorinostat (JAN/USAN)
MK 0683
UNII-58IFB293JI
SKI390
suberoyl anilide hydroxamic acid
N Hydroxy N' phenyloctanediamide
4lxz
N1 Hydroxy N8 phenyloctanediamide
Vorinostat(SAHA)
Zolinza; SAHA
18F-suberoylanilide hydroxamic acid
Vorinostat (GMP)
18F Suberoylanilide Hydroxamic Acid
SAHA, Suberoylanilide hydroxamic acid
Vorinostat (SAHA)?
Vorinostat (Standard)
1zz1
SW-064652
8-(hydroxyamino)-8-oxo-N-phenyl-octanamide
cid_5311
SCHEMBL9018
Suberoylanilidehydroxamic Acid
MLS001065855
MLS006011941
GTPL6852
BDBM19149
Vorinostat - Bio-X trade mark
Vorinostat (SAHA; MK0683)
L01XX38
MSK-390
n-hydroxy-n'-phenyl-octanediamide
SUBERANILOHYDROXAMINIC ACID
1t69
N-hydroxy-N''-phenyloctanediamide
BCPP000018
HMS2219L20
HMS3264D20
HMS3327C12
HMS3426G03
HMS3650D09
HMS3654G11
HMS3715E22
HMS3745M03
Pharmakon1600-01502267
BCP01858
EX-A2745
HVB74948
SAHA, >=98% (HPLC)
Vorinostat,SAHA,Zolinza,MK-0683
Tox21_112605
Tox21_113623
Vorinostat,CAS:149647-78-9
HB1396
HY-10221G
HY-10221R
NSC748799
NSC759852
Octanediamide, N1-hydroxy-N8-phenyl
s1047
SK1390
AKOS015966648
Tox21_112605_1
AC-1923
CCG-208659
CS-0589
DB02546
DG-0025
FH15949
SB17319
NCGC00168085-03
NCGC00168085-04
NCGC00168085-05
NCGC00168085-13
BP-25652
BP-30216
BV164560
HY-10221
SY009383
H1388
NS00068618
SW199536-4
D06320
EN300-120641
N-Hydroxy-N'-phenyl-octanediamide;Zolinza;SAHA
AB00375377-07
AB00375377-08
AB00375377-09
AB01644613_25
Q905901
Vorinostat, SAHA, suberoylanilide hydroxamic acid
SR-05000000373-2
SR-05000000373-6
SR-05000000373-8
BRD-K81418486-001-01-2
BRD-K81418486-001-10-3
BRD-K81418486-001-12-9
BRD-K81418486-001-13-7
BRD-K81418486-001-17-8
BRD-K81418486-001-18-6
BRD-K81418486-001-44-2
BRD-K81418486-001-47-5
L-001079038
Z1530532755
N-Hydroxy-N inverted exclamation mark -phenyloctanediamide
N-Hydroxy-N'-phenyl-octanediamide; Suberoylanilide hydroxamic acid; SAHA
1227736-21-1
682-505-1