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Flavopiridol

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Identification
Molecular formula
C21H20ClNO5
CAS number
146426-40-6
IUPAC name
8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one
State
State

At room temperature, Flavopiridol exists as a solid in the form of a crystalline powder.

Melting point (Celsius)
259.00
Melting point (Kelvin)
532.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
401.44g/mol
Molar mass
401.4350g/mol
Density
1.3590g/cm3
Appearence

Flavopiridol is typically found as a yellow crystalline powder.

Comment on solubility

Solubility of 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one

The solubility of the compound 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one, with the chemical formula C21H20ClNO5, is influenced by various factors, primarily structural attributes and intermolecular interactions. Generally, this compound is expected to exhibit the following solubility characteristics:

  • Polar Solvents: Given the presence of the dimethylamino and methoxy groups, the compound may show some degree of solubility in polar solvents such as methanol and ethanol.
  • Non-Polar Solvents: The phenyl ring suggests better solubility in non-polar solvents like chloroform or benzene, as aromatic groups often interact favorably with similar solvents.
  • Water Solubility: The compound may have limited solubility in water due to its overall hydrophobic character, particularly from the large aromatic systems.

It is essential to consider the role of temperature and concentration, which can significantly affect solubility. As temperature increases, solubility often enhances due to increased molecular motion. However, the specific solubility can vary widely and should be determined experimentally for precise applications.

In summary, while some solubility can be anticipated in polar and non-polar solvents, the limited water solubility of 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one points to a compound best utilized in non-aqueous environments.

Interesting facts

Interesting Facts about 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one

The compound known as 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one belongs to a fascinating class of molecules called flavones. These compounds are known for their diverse pharmacological properties and widespread occurrence in plants. Here are some intriguing aspects of this particular chemical:

  • Structural Complexity: This compound features an intricate structure that includes a chromone backbone, which is characteristic of many biologically active phytochemicals. Its structural uniqueness allows for a variety of chemical interactions.
  • Biological Activity: Compounds of this nature have been observed to exhibit significant antioxidant, anti-inflammatory, and antimicrobial properties. Research into its potential medicinal uses could lead to valuable applications in the pharmaceutical industry.
  • Synthetic Pathways: The synthesis of this compound can be approached via several methods, which can include multi-step reactions. Understanding these pathways can enhance the efficiency of producing the compound for research purposes.
  • Applications in Research: This flavone derivative may serve as a useful intermediate or a lead compound in the development of new therapeutic agents, particularly in the study of cancer therapies and neuroprotection.
  • Intriguing Tags: The presence of a dimethylamino group in its structure enhances the molecule's ability to interact with biological systems, representing a fascinating example of how small changes in molecular architecture can lead to significant differences in activity.

In summary, 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-chromen-4-one not only showcases the beauty of organic chemistry with its complex structure but also holds promise for future biological applications that could impact human health. The exploration of such compounds continues to be a vibrant area of research in both synthetic chemistry and pharmacology.

Synonyms
DIMEFLINE
Dimeflin
Dimelfin
Malivan
Reanimil
1165-48-6
Dimeflina
Remeflin
Remeflin (VAN)
Dimeflinum
Dimefline [INN:BAN]
Dimeflinum [INN-Latin]
Dimeflina [INN-Spanish]
NSC 169869
HSDB 2110
UNII-9WII5M0DU3
EINECS 214-616-4
9WII5M0DU3
Dimefline (INN)
NSC-169869
BRN 1395114
8-(Dimethylaminomethyl)-7-methoxy-3-methylflavone
8-((Dimethylamino)methyl)-7-methoxy-3-methylflavone
DW 62
DIMEFLINE [INN]
4H-1-Benzopyran-4-one, 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-
DIMEFLINE [MI]
N-(7-Methoxy-3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)methyl-N,N-dimethylamine
DIMEFLINE [HSDB]
DW 62 (Salt/Mix)
NSC169869
DIMEFLINE [WHO-DD]
Flavone, 8-(dimethylaminomethyl)-7-methoxy-3-methyl-
4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-
8-Dimethylaminomethyl-7-methoxy-3-methyl-2-phenylchromone
DTXSID0048268
Rec 7/0267 (Salt/Mix)
8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenylflavone
3-Methyl-7-methoxy-8-dimethylamino-methylflavone
5-18-12-00083 (Beilstein Handbook Reference)
8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4H-1-benzopyran-4-one
Dimeflinum (INN-Latin)
Remeflin (TN)
Dimeflina (INN-Spanish)
8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4H-chromen-4-one
8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenylchromen-4-one
3-Methyl-7-methoxy-8-[(dimethylamino)methyl]flavone
8-[(Dimethylamino)methyl]-7-methoxy-3-methylflavone
Flavone, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-
Flavone, 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-
8-((Dimethylamino)methyl)-7-methoxy-3-methyl-2-phenylchromone
NSC114650
NCGC00181097-01
3-Methyl-7-methoxy-8-((dimethylamino)methyl)flavone
8-[(Dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4H-chromen-4-one
SCHEMBL668130
CHEMBL519364
DTXCID5028243
R07AB08
CHEBI:135374
DB13482
NCI60_000333
NCI60_001369
NS00045985
D07847
WLN: T66 BO EVJ CR& D1 IO1 J1N1&1
Q5277233
8-(dimethylaminomethyl)-7-methoxy-3-methyl-2-phenyl-chromen-4-one
8-[(Dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4H-chromen-4-one #
4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-(9CI)
214-616-4