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Diclazepam

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Identification
Molecular formula
C16H12Cl2N4O
CAS number
2894-68-0
IUPAC name
[8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol
State
State

At room temperature, Diclazepam is generally in a solid state. It is a crystalline powder under standard laboratory conditions and is sparingly soluble in water.

Melting point (Celsius)
86.50
Melting point (Kelvin)
359.65
Boiling point (Celsius)
473.00
Boiling point (Kelvin)
746.15
General information
Molecular weight
319.20g/mol
Molar mass
319.1906g/mol
Density
1.4560g/cm3
Appearence

Diclazepam is typically available in the form of white or off-white powder or crystalline solid. It may also be synthesized into tablet form for research purposes. The compound is perceived to have a fine-grained consistency when processed and a characteristic appearance typical of benzodiazepine derivatives.

Comment on solubility

Solubility of [8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol (C16H12Cl2N4O)

The solubility of the compound [8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol in various solvents can vary significantly based on its unique molecular structure. In general, the factors affecting solubility include:

  • Polarity: As a molecule containing both polar and non-polar functional groups, its solubility may be higher in polar solvents such as water, but lower in non-polar solvents.
  • Hydrogen Bonding: The presence of the hydroxyl group (-OH) may enhance solubility in protic solvents, making it more soluble in alcohols or aqueous solutions compared to purely hydrophobic environments.
  • Temperature: Like many organic compounds, solubility can be influenced by temperature, often increasing with higher temperatures.

In conclusion, while specific quantitative solubility values for this compound may be limited, its structural characteristics suggest that it should have a moderate solubility profile, particularly in polar, protic solvents. Understanding its solubility behavior is crucial for applications in pharmaceuticals where formulation and bioavailability are key considerations.

Interesting facts

Interesting Facts About 8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol

This compound belongs to a specialized class known as benzodiazepines, which are primarily recognized for their effects on the central nervous system. It showcases a fascinating blend of multiple functional groups that underline its potential pharmacological properties.

Key Highlights:

  • Pharmacological Significance: Benzodiazepines are extensively studied for their anxiolytic, hypnotic, muscle relaxant, and anticonvulsant properties. This compound contributes to this rich therapeutic landscape.
  • Triazole Integration: The incorporation of a triazole ring enhances the compound's bioactivity, making it a subject of interest for medicinal chemistry. Such modifications can lead to improved metabolic stability and activity.
  • Chlorinated Variants: The presence of chlorine atoms in its structure often implies enhanced lipophilicity, which can aid in the compound’s ability to cross biological membranes.
  • Research Applications: Compounds of this nature have been investigated in academic and clinical settings for their potential in addressing various mental health disorders.

The compound also stimulates significant interest within the field of drug design. According to a prominent researcher, “the development of such modified benzodiazepines could result in safer and more effective therapies.” This aligns with ongoing efforts in pharmacology to optimize drug profiles while minimizing side effects.

Overall, the unique structure of 8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol encapsulates the intersection of chemistry and medicine, revealing implications that extend into therapeutic applications.

Synonyms
alpha-Hydroxytriazolam
37115-45-0
1'-Hydroxy Triazolam
1'-hydroxytriazolam
[8-chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl]methanol
1-Hydroxymethyltriazolam
J53Y2M2SAH
4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine-1-methanol, 8-chloro-6-(2-chlorophenyl)-
.ALPHA.-HYDROXYTRIAZOLAM
DTXSID50958284
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-1-methanol, 8-chloro-6-(2-chlorophenyl)-
8-CHLORO-6-(O-CHLOROPHENYL)-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPIN-1-METHANOL
1'-Hydroxy Triazolam (1.0 mg/mL in DMSO)
(8-chloro-6-(2-chlorophenyl)-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-yl)methanol
.alpha.-hydroxy-triazolam
UNII-J53Y2M2SAH
alpha-Hydroxytriazolam solution
CHEMBL3246753
SCHEMBL10404543
DTXCID50908507
CHEBI:166535
AKOS030254397
HY-W739861
NCGC00485016-01
Alpha-Hydroxytriazolam, 1mg/ml in Methanol
CS-0786363
NS00010451
alpha-Hydroxytriazolam 0.1 mg/ml in Methanol
alpha-Hydroxytriazolam 1.0 mg/ml in Methanol
6-(o-chlorophenyl)-8-chloro-4 h-s-triazolo[4,3-a] [1,4]benzodiazepine-1-methanol
6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-methanol
8-chloro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
8-chloro-6-(o-chlorophenyl)-1-hydroxymethyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepine
(E)-(8-chloro-6-(2-chlorophenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)methanol
636-834-2