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Alprazolam

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Identification
Molecular formula
C17H13Cl2N5
CAS number
28981-97-7
IUPAC name
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
State
State

At room temperature, alprazolam is a solid. It is commonly available in tablet form for oral administration.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
361.50
Boiling point (Kelvin)
634.65
General information
Molecular weight
308.77g/mol
Molar mass
308.7650g/mol
Density
1.3000g/cm3
Appearence

Alprazolam is typically found as a white, crystalline powder. It is odorless and is usually prepared in tablet form for pharmaceutical use.

Comment on solubility

Solubility of 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

The solubility of 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (C17H13Cl2N5) can be characterized by several key points:

  • Polarity Influence: The presence of chlorine atoms can alter the polarity of the molecule, often leading to lower solubility in polar solvents while enhancing solubility in nonpolar environments.
  • Functional Groups: The triazolo and benzodiazepine structures introduce several functional aspects that influence solubility trends. Generally, benzodiazepines are known for their variable solubility based on their specific substitutions.
  • Solvent Compatibility: As with many organic compounds, solubility is highly dependent on the solvent employed. Common solvents such as DMSO or methanol may exhibit higher levels of solubility compared to water.
  • Temperature Dependence: Increased temperature can lead to increased solubility for many compounds; hence, exploring solubility at varied temperatures could provide valuable insights.

In conclusion, while precise solubility values may vary, the aforementioned factors play a critical role in determining how well this compound dissolves in various solvents. A thorough examination is essential for practical applications and further research.

Interesting facts

Interesting Facts about 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

This fascinating compound is a member of the benzodiazepine family, which is renowned for its psychoactive properties. These compounds are primarily known for their efficacy as anxiolytics, which means they can help in reducing anxiety and promoting a sense of calm in individuals.

Key Characteristics:

  • Psychoactive Properties: Compounds in this class often exhibit sedative, hypnotic, and muscle-relaxant effects.
  • Mechanism of Action: They typically function by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor in the brain.
  • Pharmacological Interest: The unique structure of this compound may offer distinctive therapeutic benefits, which can be of great interest in drug design and development.

One of the more intriguing aspects of this compound is its specific modifications, such as the presence of chlorine atoms. These halogen substitutions can significantly influence the compound's biological activity and pharmacokinetics.

As described in many studies, the triazole ring in its structure provides a unique site for interactions that could lead to varied therapeutic potentials. In the words of one researcher: "Understanding the nuances of halogenated benzodiazepines can open new doors in psychopharmacology." This highlights the ongoing research interest in such derivatives for potential innovative treatments in mental health.

Research Implications:

  • Potential for developing new medications with fewer side effects.
  • Investigating binding affinities at various receptor subtypes.
  • Exploring its use as a scaffold for synthesizing new therapeutic agents.

Overall, 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine stands as a representative of the complexity and therapeutic potential inherent in benzodiazepines, serving as a reminder of the role structural variations play in drug design and efficacy.

Synonyms
triazolam
Halcion
28911-01-5
Songar
Clorazolam
Novidorm
Novodorm
Triazolamum
Triazolamum [INN-Latin]
Triazolam civ
U-33,030
8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CCRIS 1932
DEA No. 2887
HSDB 6759
U 33030
U-33030
EINECS 249-307-3
8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
BRN 1226643
CHEBI:9674
DTXSID6046763
UNII-1HM943223R
N05CD05
4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
CHEMBL646
1HM943223R
8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine
DTXCID4026763
4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-(o-chlorophenyl)-1-methyl-
Triazolam [USAN:USP:INN:BAN:JAN]
NCGC00168258-01
Trilam
Triazolamum (INN-Latin)
TRIAZOLAM (MART.)
TRIAZOLAM [MART.]
8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
TRIAZOLAM CIV (USP-RS)
TRIAZOLAM CIV [USP-RS]
TRIAZOLAM (USP MONOGRAPH)
TRIAZOLAM [USP MONOGRAPH]
Hypnostat
Triazolam (100 ug/mL in Methanol)
Triazolam (USAN:USP:INN:BAN:JAN)
Halcion (TN)
Halcion (triazolam)
TGAR01H
Hypam
TRIAZOLAM [INN]
TRIAZOLAM [JAN]
TRIAZOLAM [MI]
TRIAZOLAM [HSDB]
TRIAZOLAM [USAN]
TRIAZOLAM [VANDF]
TRIAZOLAM [WHO-DD]
SCHEMBL29228
MLS003899243
Triazolam (JP18/USP/INN)
Triazolam, 1mg/ml in Methanol
GTPL7313
TRIAZOLAM [ORANGE BOOK]
Triazolam 0.1 mg/ml in Methanol
Triazolam 1.0 mg/ml in Methanol
HY-B0694
Tox21_112617
28911-01-5 (free)
BDBM50001765
MFCD00079623
DB00897
FT137319
SMR000058837
CAS-28911-01-5
NS00010468
8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-
D00387
U33030
L000796
Q412143
SR-01000937604
SR-01000937604-2
BRD-K76890464-001-02-3
Triazolam, European Pharmacopoeia (EP) Reference Standard
8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4] benzodiazepine
8-chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine
(E)-8-chloro-6-(2-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
12-chloro-9-(2-chlorophenyl)-3-methyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
249-307-3