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Clonazolam

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Identification
Molecular formula
C17H12ClN5
CAS number
33887-02-4
IUPAC name
8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
State
State

Clonazolam is a solid at room temperature. It typically appears as a powder or crystals.

Melting point (Celsius)
169.70
Melting point (Kelvin)
442.85
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
353.77g/mol
Molar mass
353.7650g/mol
Density
1.3000g/cm3
Appearence

Clonazolam appears as a white to light yellow powder or crystalline solid. It is insoluble in water but may dissolve in organic solvents. The compound may also present in a tablet or capsule form when prepared for pharmaceutical uses.

Comment on solubility

Solubility Insights for 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (C17H12ClN5)

The solubility of 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine is a crucial characteristic for its application in various chemical processes and pharmaceuticals. Generally, the solubility of organic compounds like this one can be influenced by several factors:

  • Molecular Structure: The presence of chlorine atoms and the benzodiazepine backbone tends to impart specific solubility properties.
  • Polarity: Compounds exhibiting polar functional groups usually show enhanced solubility in polar solvents, while nonpolar compounds are more soluble in organic solvents.
  • Hydrogen Bonding: The potential for intramolecular or intermolecular hydrogen bonding can significantly affect solubility. This compound's structure may interact differently when mixed with various solvents.
  • Temperature: Solubility can dramatically change with temperature. As temperature increases, so does the kinetic energy of particles, often leading to higher solubility levels.

While specific solubility values may not be readily available for this compound, it is typically expected to have limited solubility in water due to its relatively large size and complex structure. However, it may demonstrate considerable solubility in organic solvents such as methanol, ethanol, or dimethyl sulfoxide (DMSO). The quote, “Like dissolves like,” aptly summarizes the principle guiding solubility; thus, understanding the solubility profile of this compound is essential for its practical utilities.

In conclusion, thorough examination in laboratory settings is necessary to determine precise solubility characteristics and better inform potential applications for C17H12ClN5.

Interesting facts

Interesting Facts about 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine is a remarkable compound that has garnered attention in the field of medicinal chemistry due to its unique structure and potential applications. Below are some fascinating aspects of this compound:

  • Diverse Pharmacological Activity: This compound belongs to a class known as benzodiazepines, which are widely recognized for their effects on the central nervous system. They are often utilized for their anxiolytic (anxiety-reducing), sedative, and anticonvulsant properties.
  • Innovative Structure: The triazolo-benzodiazepine core structure of the compound adds intrigue. The incorporation of the triazole ring enhances its binding affinity to GABAA receptors, which play a critical role in neuronal inhibition.
  • Potential Therapeutic Uses: Owing to its unique molecular features, research has indicated that compounds like this one may serve as potential candidates for new therapeutic agents against anxiety disorders as well as sleep disturbances.
  • Chirality and Isomerism: This compound features chiral centers, allowing for the existence of various stereoisomers. This characteristic is essential as different isomers can exhibit vastly different biological activities.
  • Continued Research: Ongoing studies aim to better understand the mechanism of action of this compound, as well as to evaluate its safety and efficacy in clinical settings. The exploration of related compounds could lead to novel treatments in pharmacotherapy.

The exploration of 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine demonstrates the intricacies of modern medicinal chemistry and the continued pursuit of innovative solutions to challenging medical issues. As one researcher aptly stated, "The pursuit of understanding complex molecules is not just a scientific endeavor but a journey toward unlocking potential therapies for humanity."


Synonyms
alprazolam
Xanax
28981-97-7
Niravam
Trankimazin
Tranquinal
Alplax
Constan
Frontal
Solanax
Tafil
Xanor
Alpronax
Intensol
Tricalma
Xanax XR
Alcelam
Alpram
Alzolam
Anpress
Bestrol
Neurol
Prinox
Relaxol
Restyl
Valeans
Xanagis
Zolarem
Zoldac
Zotran
Alpaz
Alzam
Panix
Apo-Alpraz
Alprazolam intensol
Alprazolamum
Pharnax
Prazolan
Tensivan
Xanolam
Zacetin
Zanapam
8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Algad
Alprax
Helex
Ksalol
Mialin
Prazam
Unilan
Zaxan
Zenax
Zolam
Zoldax
Zopax
Zopic
Gen-Alprazolan
TUS-1
Tafil D
Xanax TS
D 65MT
Alprazolam civ
Tus 1
Alprazolamum [INN-Latin]
Alprazolam extended release tablets
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
HSDB 7207
UNII-YU55MQ3IZY
U 31889
U-31889
YU55MQ3IZY
U-31,889
EINECS 249-349-2
NSC-760140
BRN 1223125
Cassadan
CHEBI:2611
Esparon
DTXSID4022577
Ralozam
Alprox
CHEMBL661
Novo-Alprazol
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Nu-Alpraz
4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-1-methyl-6-phenyl-
4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-1-methyl-6-phenyl-
DTXCID102577
Alprazolan
Alzon
U 31,889
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-methyl-6-phenyl-
NSC 760140
Alprazolam [USAN:USP:INN:BAN:JAN]
NCGC00159466-02
Alprazolamum (INN-Latin)
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-alpha)(1,4)benzodiazepine
ALPRAZOLAM (MART.)
ALPRAZOLAM [MART.]
4H-(1,2,4)Triazolo(4,3-alpha)(1,4)benzodiazepine, 8-chloro-1-methyl-6-phenyl-
51339-48-1
ALPRAZOLAM (EP IMPURITY)
ALPRAZOLAM [EP IMPURITY]
ALPRAZOLAM (EP MONOGRAPH)
ALPRAZOLAM [EP MONOGRAPH]
Alprazolam (1mg/mL in Methanol)
ALPRAZOLAM (USP MONOGRAPH)
ALPRAZOLAM [USP MONOGRAPH]
Panistat
Alprazolam (USAN:USP:INN:BAN:JAN)
Staccato-alprazolam
SMR000149316
Xanax (TN)
AZ-002
TGAR01P
AlprazolamXR
Apo-Alpzar
XanaxXR
DEA No. 2882
8-chloro-1-methyl-6-phenyl-4h-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine
8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-alpha][1,4]benzodiazepine
Alprazolam C-IV
08H
ALPRAZOLAMER
Alprazolamum (Latin)
AP-1002
3u5j
ALPRAZOLAM [MI]
ALPRAZOLAM [INN]
ALPRAZOLAM [JAN]
ALPRAZOLAM [HSDB]
ALPRAZOLAM [USAN]
AlprazolamExtended Release
ALPRAZOLAM [VANDF]
SCHEMBL8398
ALPRAZOLAM [WHO-DD]
BIDD:PXR0150
MLS000559000
MLS000759485
MLS001423979
BIDD:GT0475
Alprazolam (JP17/USP/INN)
GTPL7111
Alprazolam, 1mg/ml in Methanol
ALPRAZOLAM [ORANGE BOOK]
ALPRAZOLAMEXTENDED-RELEASE
N05BA12
HMS2051A10
HMS3393A10
Pharmakon1600-01502395
Alprazolam 0.1 mg/ml in Methanol
Alprazolam 1.0 mg/ml in Methanol
BCP28608
MEA39364
Tox21_111692
BBL028160
BDBM50001728
NSC760140
STK590494
AKOS005066050
CCG-100855
DB00404
NC00105
NCGC00159466-03
AC-18721
FA111888
BNZB - Human Serum, Benzodiazepine mix B
8-Chloro-1-methyl-6-phenyl-4H-s-triazolo
CAS-28981-97-7
DB-242959
NS00010452
C06817
D00225
A819702
Q319877
BRD-K32398298-001-01-4
Alprazolam, European Pharmacopoeia (EP) Reference Standard
8-chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine
8-chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-a][1,4] benzodiazepine
8-chloro-6-phenyl-1-methyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
(Z)-8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
4H-(1,2,4)TRIAZOLO(4,3-.ALPHA.)(1,4)BENZODIAZEPINE, 8-CHLORO-1-METHYL-6-PHENYL-
8-chloranyl-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
1246182-61-5
249-349-2