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Zidovudine

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Identification
Molecular formula
C10H13N5O4
CAS number
30516-87-1
IUPAC name
8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid
State
State

Zidovudine is typically found in a solid state at room temperature. It can be formulated into tablets, capsules or in liquid form for oral consumption in antiretroviral therapy.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
269.00
Boiling point (Kelvin)
542.15
General information
Molecular weight
267.24g/mol
Molar mass
267.2410g/mol
Density
1.6600g/cm3
Appearence

Zidovudine, also known as azidothymidine (AZT), typically appears as a white crystalline powder. It is odorless and in its pure form, is also tasteless.

Comment on solubility

Solubility of 8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid

The solubility of 8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid (C10H13N5O4) can be quite intriguing due to its complex molecular structure. Here are some pertinent points regarding its solubility:

  • Hydrophilicity: The presence of multiple hydroxyl groups (-OH) and a phosphate moiety likely enhances the compound’s affinity for water, suggesting that it may be readily soluble in aqueous environments.
  • Organic Solvents: While the compound exhibits potential solubility in water, the degree of solubility in organic solvents (such as ethanol or DMSO) may vary based on the steric hindrances and intermolecular interactions.
  • Temperature Dependency: Solubility can be affected by temperature—higher temperatures often increase solubility, especially for polar compounds.

In summary, while the 8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid appears to be soluble due to its highly polar functional groups, experimental data would be necessary to confirm its solubility characteristics in various solvents. As with many bioactive compounds, solubility is a critical parameter that influences both pharmacokinetics and bioavailability.

Interesting facts

Interesting Facts about 8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid

This compound is a fascinating example of a biologically relevant molecule that lies at the intersection of pharmacology and organic chemistry. It has garnered attention due to its potential applications in medicinal chemistry, specifically in the development of therapeutic agents targeting various diseases.

Key Features:

  • Complex Structure: The intricate structure of this compound features a pyrimidine ring, which is crucial for its biological activity. Pyrimidines are key components in nucleic acids and can play significant roles in metabolic processes.
  • Functional Groups: The presence of multiple hydroxyl groups contributes to the compound's solubility and reactivity, potentially influencing its interaction with biological macromolecules.
  • Phosphoryl Group: The inclusion of a phosphoryl group enhances its ability to form hydrogen bonds and may improve its efficacy in biological systems, making it more biologically active.

Moreover, research in this area emphasizes the crucial role of such compounds in drug design and the development of enzyme inhibitors. In quotes from prominent researchers, there is often mention of how “the understanding of these complex molecules can lead us to new horizons in targeted therapy.”

Applications in Research:

This compound is a part of ongoing studies aiming to combat diseases by:

  • Investigating its role in signal transduction pathways, which are vital for cellular communication and function.
  • Exploring its capacity to inhibit specific enzyme activity relevant in cancer & metabolic disorders.
  • Utilizing its structure as a framework for designing new agents that can improve upon existing therapeutic strategies.

In summary, the investigation of 8-[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-4,5,6,7-tetrahydroxy-2-oxo-octanoic acid reveals not only the beauty of organic chemistry but also the potential for advancing healthcare solutions. With continuous research, it is hopeful that such compounds will pave the way for novel therapeutic interventions.