Skip to main content

Fluspirilene

ADVERTISEMENT
Identification
Molecular formula
C29H31F2N3O
CAS number
1841-19-6
IUPAC name
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
State
State

At room temperature, Fluspirilene exists as a solid crystalline substance. It is stable under normal conditions and is not hygroscopic, meaning it does not readily absorb moisture from the environment.

Melting point (Celsius)
97.30
Melting point (Kelvin)
370.45
Boiling point (Celsius)
312.30
Boiling point (Kelvin)
585.45
General information
Molecular weight
437.58g/mol
Molar mass
437.5810g/mol
Density
1.3670g/cm3
Appearence

Fluspirilene is typically a white or off-white crystalline powder. It does not have a strong odor, and it is primarily used in pharmaceutical applications as an antipsychotic drug.

Comment on solubility

Solubility of 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

The solubility characteristics of this compound, with the molecular formula C29H31F2N3O, can be intriguing due to its complex chemical structure. Understanding the solubility of such compounds is crucial for applications in pharmaceuticals and materials science.

  • Polarity: The presence of multiple aromatic rings and a triazole moiety can suggest varying degrees of polarity. The fluorine atoms introduce electronegativity, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The carbonyl group (C=O) and nitrogen atoms in the structure can participate in hydrogen bonding, potentially increasing solubility in polar and protic solvents.
  • Solvent Compatibility: This compound may show better solubility in dimethyl sulfoxide (DMSO) or dimethylformamide (DMF) due to their ability to solvate both polar and nonpolar regions of the molecule.

However, the overall solubility can be limited by its large hydrophobic regions which tend to aggregate in aqueous solutions. A meticulous approach in examining solubility across different pH levels and solvent systems is vital. In summary, while the compound shows potential solubility in certain solvents, the exact conditions should be optimized based on its physicochemical properties.

Interesting facts

Interesting Facts about 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

This compound, known for its complex structure and unique properties, falls under the category of spirocyclic compounds. Spiro compounds are distinguished by having two or more rings that share a single atom, which in this case involves a spiro nitrogen framework. Here are some fascinating insights about this particular compound:

  • Unusual Structure: The presence of both spirocyclic and triazole functionalities makes this compound especially interesting for synthetic chemists.
  • Potential in Drug Design: Its diverse structural features could allow for the creation of molecules with novel pharmacological properties, making it a candidate for drug development.
  • Fluorine Substitution: The 4-fluorophenyl groups can enhance metabolic stability and improve the permeability of the compound through biological membranes.
  • Biological Interest: Compounds similar to this one have shown promise in various biological applications, particularly in the fields of neuroscience and oncology.
  • Research Trends: Current research is delving into how modifications to the triaza core can influence the compound's activity and selectivity, making it a topic of significant interest in modern medicinal chemistry.

The intricate balance of nitrogen and carbon atoms within this compound foreshadows exciting possibilities in chemical synthesis and therapeutic applications. Its design highlights the precision required in drug development—balancing potency, selectivity, and safety to address complex diseases.

Furthermore, as noted by chemists, "The beauty of synthetic chemistry lies in crafting molecules that can define their own therapeutic paths." Thus, compounds like this one not only exhibit structural elegance but also pave the way for innovative medical solutions.

Synonyms
Fluspirilene
1841-19-6
Redeptin
Imap
Fluspirileno
McN-JR-6218
R 6218
Fluspirilenum [INN-Latin]
Fluspirileno [INN-Spanish]
Fluspirilenum
Fluspiriline
Fluspirilen
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Fluspirilene [USAN:INN:BAN]
C5QA4GLR9M
EINECS 217-418-6
R-6218
BRN 0633853
DTXSID7045152
R 6218;Redeptin
1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane
8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one
FLUSPIRILENE [MI]
FLUSPIRILENE [INN]
FLUSPIRILENE [USAN]
FLUSPIRILENE [MART.]
1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-
CHEMBL46516
FLUSPIRILENE [WHO-DD]
McN-JR 6218
Spirodiflamine
DTXCID5025152
FLUSPIRILENE [EP MONOGRAPH]
5-26-04-00097 (Beilstein Handbook Reference)
1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-
NCGC00015424-04
NCGC00015424-11
CAS-1841-19-6
Fluspirilenum (INN-Latin)
Fluspirileno (INN-Spanish)
1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4,4-bis(p-fluorophenyl)butyl]-1-phenyl-
FLUSPIRILENE (MART.)
FLUSPIRILENE (EP MONOGRAPH)
1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(p-fluorophenyl)butyl)-1-phenyl-
8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4,5)decan-4-one
SMR000058304
Imap (TN)
Lopac-F-100
SR-01000075385
UNII-C5QA4GLR9M
Fluspirilene (USAN/INN)
8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one
8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Fluspirilene; 8-[4,4-bis(4-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Prestwick0_000906
Prestwick1_000906
Prestwick2_000906
Prestwick3_000906
F-100
GTPL85
8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one
cid_3396
Lopac0_000518
Oprea1_804941
SCHEMBL42082
BSPBio_000752
BSPBio_001343
MLS000069357
MLS001333730
SPBio_002951
BPBio1_000828
BDBM26948
CHEBI:93369
N05AG01
TQP0727
HMS1570F14
HMS1791D05
HMS1989D05
HMS2089C15
HMS2097F14
HMS2233B20
HMS3261H17
HMS3372H20
HMS3402D05
HMS3714F14
BCP09254
Fluspirilene (R 6218; Redeptin)
HY-B1655
Tox21_110142
Tox21_500518
Fluspirilene (R 6218; Redeptin)?
MFCD00055137
NSC772296
8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
AKOS015969747
Tox21_110142_1
CCG-204608
DB04842
LP00518
NSC-772296
SDCCGSBI-0050501.P002
NCGC00015424-01
NCGC00015424-02
NCGC00015424-03
NCGC00015424-05
NCGC00015424-06
NCGC00015424-07
NCGC00015424-08
NCGC00015424-09
NCGC00015424-10
NCGC00015424-15
NCGC00016595-01
NCGC00093913-01
NCGC00093913-02
NCGC00093913-03
NCGC00093913-04
NCGC00093913-05
NCGC00261203-01
AS-16749
DA-73412
FF137462
AB00513956
CS-0013609
EU-0100518
NS00010091
D02629
G12130
AB00513956-10
EN300-18531108
L001195
Q408300
SR-01000075385-1
SR-01000075385-5
BRD-K77947974-001-04-9
BRD-K77947974-001-16-3
217-418-6