Skip to main content

Prednisone Acetate

ADVERTISEMENT
Identification
Molecular formula
C23H28ClFO5
CAS number
52-21-1
IUPAC name
8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
State
State

At room temperature, prednisone acetate is in a solid state.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
495.45
Boiling point (Kelvin)
768.60
General information
Molecular weight
402.88g/mol
Molar mass
402.8780g/mol
Density
1.5000g/cm3
Appearence

Prednisone acetate is a white or almost white crystalline powder. It is practically insoluble in water, slightly soluble in acetone and in chloroform, and slightly soluble in alcohol.

Comment on solubility

Solubility of 8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

The solubility of this complex organic compound, represented by the chemical formula C23H28ClFO5, can be influenced by several factors due to its intricate molecular structure. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of polar functional groups such as hydroxyl (-OH) and carbonyl (C=O) may enhance solubility in polar solvents, while the hydrophobic hydrocarbon skeleton may limit solubility in water.
  • Solvent Compatibility: This compound may exhibit improved solubility in organic solvents like ethanol, methanol, or acetone, which can disrupt intermolecular interactions more effectively.
  • Temperature Effects: Generally, solubility increases with temperature; thus, heating the solvent could facilitate the dissolution of this compound.
  • Concentration Dependency: High concentrations might lead to precipitation, suggesting an upper limit on solubility in certain solvents.

In summary, while this compound may have limited solubility in water due to its bulky hydrophobic structures, it could dissolve better in suitable organic solvents, emphasizing the importance of selecting the right solvent system during experiments or applications involving this compound.

Interesting facts

Interesting Facts about 8-(2-Chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

This compound, with such a complex name, is a member of a fascinating class of organic compounds known for their unique structural features. Let's explore some of its intriguing aspects:

  • Molecular Complexity: The structure features multiple rings that provide it with a distinct pentacyclic configuration, making it a subject of interest in synthetic organic chemistry.
  • Fluorine's Role: The inclusion of fluorine in its structure often enhances the compound's biological activity and stability, making it a valuable point of study in medicinal chemistry.
  • Chloroacetyl Group: The presence of the chloroacetyl moiety suggests potential reactivity that could be exploited in further chemical transformations, opening pathways for novel synthesis methods.
  • Hydroxyl Functionalization: With a hydroxyl group in its structure, this compound may exhibit hydrogen bonding capabilities that could influence its interactions with biological systems.
  • Potential Applications: Compounds of this nature may serve significant roles in pharmaceutical chemistry, possibly being explored for their therapeutic effects or as intermediates in drug synthesis.

As one delves deeper into its chemical properties, the complexity and functionality of this compound unveil opportunities for exciting research and development in several fields, especially drug discovery and materials science.

Synonyms
Halog
Alcinonide
8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
SQ-18,566
SCHEMBL13026159
DTXSID00859792
MUQNGPZZQDCDFT-UHFFFAOYSA-N
Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11.beta.,16.alpha.)-
(11.beta.,16.alpha.)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
(1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9.0^{4,8.0^{13,18]icos-17-en-16-one
21-Chloro-9-fluoro-11.beta.,16.alpha.,17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone
6b-(Chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
6b-(Chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one #
Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-.beta.,16-.alpha.,17-trihydroxy-, cyclic16,17-acetal with acetone