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7-Nitroindazole-2-carboxamidine

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Identification
Molecular formula
C9H8N4O2
CAS number
50909-07-4
IUPAC name
7-nitroindazole-2-carboxamidine
State
State

7-Nitroindazole-2-carboxamidine is typically a solid at room temperature.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
207.00
Boiling point (Kelvin)
480.15
General information
Molecular weight
248.23g/mol
Molar mass
248.2250g/mol
Density
1.3600g/cm3
Appearence

7-Nitroindazole-2-carboxamidine appears as a yellow solid. It is typically encountered in powdered form.

Comment on solubility

Solubility of 7-Nitroindazole-2-carboxamidine

The solubility of 7-nitroindazole-2-carboxamidine (C9H8N4O2) can be quite interesting to explore. This compound presents a unique set of characteristics that influence its solubility in various solvents. Here are some key points to consider:

  • Polar vs Non-Polar Solvents: Due to the presence of both nitrogen and carboxamide groups, 7-nitroindazole-2-carboxamidine tends to exhibit higher solubility in polar solvents like water and dimethyl sulfoxide (DMSO).
  • Hydrogen Bonding: The ability of the carboxamide group to form hydrogen bonds can significantly enhance solubility in aqueous solutions.
  • pH Influence: The solubility might also vary with pH, where changes can affect the ionization of the respective functional groups, thus altering the overall solubility behavior.
  • Temperature Dependency: As with many organic compounds, an increase in temperature generally leads to increased solubility.

In summary, 7-nitroindazole-2-carboxamidine tends to be more soluble in polar environments, largely influenced by its functional groups. Understanding these solubility characteristics is crucial for applications involving this compound.

Interesting facts

Interesting Facts about 7-Nitroindazole-2-Carboxamidine

7-Nitroindazole-2-carboxamidine is a fascinating chemical compound that has garnered attention in various fields of scientific research. Here are some key points to consider:

  • Biological Significance: This compound is known primarily for its role as a selective inhibitor of nitric oxide synthase (NOS). Nitric oxide (NO) is a critical signaling molecule in the body, and studying its pathways can lead to insights into numerous physiological processes.
  • Medical Research: The impact of 7-nitroindazole-2-carboxamidine extends into pharmacology, particularly regarding neuroprotective applications. Its inhibition of NOS has led to investigations into its potential therapeutic effects on neurodegenerative diseases.
  • Structural Characteristics: The presence of a nitro group and a carboxamidine functional group in its structure contributes to its unique reactivity and selectivity, making it a tool for understanding complex biological systems.
  • Research Variety: Beyond biological applications, this compound is also explored in studies related to heterocyclic chemistry and the development of new materials.
  • Impact on NOS Research: The compound has been used in various *in vitro* and *in vivo* studies, providing essential insights into the mechanisms of nitric oxide-related signaling, which is crucial in cardiovascular health and disease.

As scientists continue to explore 7-nitroindazole-2-carboxamidine, its unique properties and effects could pave the way for innovative treatments and a deeper understanding of nitric oxide's role in health and disease.

Synonyms
7-nitroindazole-2-carboxamidine
7-nitro-2h-indazole-2-carboximidamide
7I2
SCHEMBL4315825
DB03065
PD007417
NS00069477
Q27094026