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Harmaline

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Identification
Molecular formula
C13H14N2O
CAS number
304-21-2
IUPAC name
7-methoxy-1-methyl-2H-pyrido[3,4-b]indole
State
State

Harmaline is a solid at room temperature. It is stable under normal conditions but should be handled with care to prevent degradation.

Melting point (Celsius)
256.00
Melting point (Kelvin)
529.15
Boiling point (Celsius)
357.00
Boiling point (Kelvin)
630.15
General information
Molecular weight
214.27g/mol
Molar mass
214.2690g/mol
Density
1.2860g/cm3
Appearence

Harmaline is a crystalline solid that appears as a white to slightly yellow powder. It is typically fine and can be distributed evenly, making it suitable for laboratory usage.

Comment on solubility

Solubility of 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole (C13H14N2O)

The solubility of 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole is influenced by various factors including its chemical structure and functional groups. This compound features a pyridoindole core with a methoxy and a methyl substituent, which can significantly affect its interaction with solvents.

Generally speaking, the solubility characteristics can be summarized as follows:

  • Polarity: The presence of the methoxy group suggests a degree of polarity that may enhance solubility in polar solvents, such as
    • Water
    • Alcohols
  • Non-polar Solvents: Given its overall structure, it may also exhibit some solubility in non-polar solvents, including
    • Hexane
    • Toluene
  • Hydrogen Bonding: The nitrogen atoms in the indole structure can potentially engage in hydrogen bonding, which might further influence solubility in certain environments.

In conclusion, while 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole shows potential for solubility in a range of solvents due to its functional groups and structure, predictive solubility tests are essential to evaluate the exact behavior in various media. As it is often said, "Solubility is the key to application," underscoring the importance of understanding how this compound interacts with different solvents for practical use.

Interesting facts

Interesting Facts About 7-Methoxy-1-Methyl-2H-Pyrido[3,4-b]Indole

7-Methoxy-1-methyl-2H-pyrido[3,4-b]indole is a fascinating compound that has caught the attention of many researchers due to its unique chemical structure and potential applications.

Structure and Characteristics

  • Pyrido-Indole Framework: This compound belongs to a family of compounds known as pyridoindoles, which feature a fused pyridine and indole moiety. This gives it intriguing electronic properties.
  • Substituents: The presence of a methoxy group and a methyl group contributes to its unique pharmacological profile, potentially influencing its biological activity.

Biological and Pharmacological Potential

Emerging studies indicate that compounds like 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole may exhibit various biological activities:

  • Antioxidant Activity: Compounds in the pyridoindole class have shown antioxidant properties, which could play a role in protecting cells from oxidative damage.
  • Neuroprotective Effects: Some research suggests that there's potential for neuroprotective benefits, making it an intriguing candidate for studies related to neurodegenerative diseases.
  • Anticancer Activity: Preliminary data indicates that this compound might possess anticancer properties, making it a subject of investigation in the field of cancer research.

Research Applications

Given its unique structure and properties, 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole is under exploration for:

  • Medicinal Chemistry: Its potential as a lead compound in drug design.
  • Natural Product Isolation: Targeted extraction from natural sources where similar compounds have been found.

"Science knows no borders; it only knows frontiers." - Sir Isaac Newton
The study of such compounds exemplifies the frontiers in medicinal chemistry that scientists are continually pushing. Research on 7-methoxy-1-methyl-2H-pyrido[3,4-b]indole highlights the exciting possibilities within the realm of chemistry and its implications for health and disease.