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Acriflavine

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Identification
Molecular formula
C15H15N3O
CAS number
92-61-5
IUPAC name
7-ethoxyacridine-3,9-diamine
State
State

Acriflavine is a solid at room temperature. In its pure form, it is crystalline and may appear as a reddish-orange powder. It is usually handled as a hydrochloride salt for medicinal purposes.

Melting point (Celsius)
257.00
Melting point (Kelvin)
530.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
265.31g/mol
Molar mass
265.3070g/mol
Density
1.1830g/cm3
Appearence

Acriflavine is typically a reddish-orange powder. It is often used in a hydrochloride form, where it presents as a dark reddish-brown substance with a crystalline nature. The compound may also be found in tablet or solution form, particularly for pharmaceutical and antiseptic applications.

Comment on solubility

Solubility of 7-ethoxyacridine-3,9-diamine

7-ethoxyacridine-3,9-diamine, with the chemical formula C15H15N3O, presents interesting solubility characteristics that are pivotal for its applications in various fields such as pharmaceuticals and materials science. Understanding the solubility of this compound involves several key considerations:

  • Polarity: The presence of the ethoxy group contributes to the overall polarity of the compound, which can influence its solubility in different solvents.
  • Solvent Interactions: 7-ethoxyacridine-3,9-diamine is expected to have varying solubility in:
    • Aqueous solutions: May exhibit limited solubility depending on pH and temperature.
    • Organic solvents: Likely soluble in non-polar to moderately polar organic solvents due to its hydrophobic acridine core.
  • Temperature Effects: The solubility can increase with temperature, making it essential to evaluate the compound's behavior in different thermal conditions.
  • pH Dependency: Changes in the pH of the solution could alter its solubility by affecting ionization states of the amine groups.

In conclusion, solubility is a complex parameter that should be experimentally verified for specific applications of 7-ethoxyacridine-3,9-diamine. As noted, "A compound's solubility does not merely define its usability but expands the horizon for its applications."

Interesting facts

Interesting Facts about 7-Ethoxyacridine-3,9-diamine

7-Ethoxyacridine-3,9-diamine is a fascinating compound that has piqued the interest of chemists due to its unique structure and potential applications. Here are some intriguing points about this compound:

  • Fluorescent Properties: This compound is known for its potential as a fluorescence probe, making it useful in various biological imaging techniques.
  • Application in Cancer Research: It has been investigated for its role in anti-cancer therapy, particularly in the development of new chemotherapeutic agents. The acridine backbone is known for its ability to intercalate DNA, which can disrupt cancer cell replication.
  • Role as a DNA Binding Agent: Due to its polycyclic structure, 7-ethoxyacridine-3,9-diamine can effectively bind to nucleic acids, offering insights into nucleic acid research.
  • Synthesis Challenges: The synthesis of this compound can be complex, often requiring specific conditions and reagents that may not readily be available, thus providing a significant challenge in its preparation.
  • Potential in Nanotechnology: Research is ongoing to explore its use in developing nanomaterials, leveraging its interaction with various substrates.
  • Colorimetric Sensitivity: 7-Ethoxyacridine-3,9-diamine shows remarkable sensitivity to environmental changes, making it a candidate for the development of colorimetric sensors.

In summary, 7-ethoxyacridine-3,9-diamine stands out not only for its structure but also for its multifaceted applications in scientific research. Its continued study could lead to significant advancements in both medicinal chemistry and nanotechnology.

Synonyms
ETHACRIDINE
7-ethoxyacridine-3,9-diamine
442-16-0
2-Ethoxy-6,9-diaminoacridine
Etakridin
Aethacridinum
Etacridina
6,9-Diamino-2-ethoxyacridine
2,5-Diamino-7-ethoxyacridine
Ethacridinum
Ethodin
Ophosept
3,9-Acridinediamine, 7-ethoxy-
Ethacridine [INN:BAN]
Etacridina [INN-Spanish]
Ethacridinum [INN-Latin]
NSC 163296
Acridine, 6,9-diamino-2-ethoxy-
UNII-WIX85M1A6R
EINECS 207-130-9
WIX85M1A6R
Ophosept (TN)
Ethacridine (INN)
NSC-163296
7-Ethoxy-3,9-acridinediamine
Acrinol (monohydrate)
ETHACRIDINE [MI]
ETHACRIDINE [INN]
ETHACRIDINE [WHO-DD]
CHEMBL94007
7-Ethoxy-3,9-diaminoacridine
DTXSID2048402
Acridine, 6,9-diamino-2-ethoxy- (8CI)
Etacridina (INN-Spanish)
Ethacridinum (INN-Latin)
Neo Chinosol
NCGC00160650-01
2,5 Diamino 7 ethoxyacridine
Ethoxyacridine-6,9-diamine 2-hydroxypropionate monohydrate
3, 7-ethoxy-
Cambridge id 5373030
acrinolum (for the lactate)
SCHEMBL193949
Acridine,9-diamino-2-ethoxy-
DTXCID0028375
BDBM24709
B05CA08
D08AA01
CHEBI:135032
BBL012339
MFCD00438481
NSC163296
STK053900
AKOS000541897
3,9-Acridinediamine, 7-ethoxy-(9CI)
Acridine, 6,9-diamino-2-ethoxy-(8CI)
AS-13274
SBI-0207078.P001
HY-122041
CS-0081404
NS00007760
D07924
AB00277299_02
BRD-K24715592-043-01-4
BRD-K24715592-043-02-2
BRD-K24715592-406-01-3
BRD-K24715592-406-02-1
Q27292662
207-130-9