Interesting facts
Interesting Facts about 7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
The compound 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one is an intriguing member of the benzodiazepine family, known for its diverse pharmacological properties. Benzodiazepines are primarily recognized for their roles as anxiolytics, sedatives, and muscle relaxants. Below are some captivating aspects of this compound:
- Synthetic Origins: The synthesis of benzodiazepines typically involves complex chemical reactions that allow for the introduction of various substituents, like the chlorine atom in this compound, which can significantly enhance its activity and specificity.
- Pharmacological Potential: Compounds of this class have been investigated for their potential therapeutic effects in treating anxiety disorders, insomnia, and even certain types of epilepsy. The specific arrangement of the chlorine and phenyl groups can influence the compound's binding affinity to neurotransmitter receptors.
- Structural Diversity: The presence of different functional groups, such as the phenyl group in this compound, contributes to the structural diversity found within the benzodiazepine family, leading to unique mechanisms of action in biological systems.
- Research Interest: Due to its potential applications, 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one has attracted attention in medicinal chemistry, prompting studies focused on enhancing its efficacy and minimizing side effects.
In the world of medicinal chemistry, understanding the intricate details of such compounds leads to significant advancements in pharmaceuticals. As highlighted by research, "the efficacy and safety of benzodiazepines can be optimized through a comprehensive understanding of their structure-activity relationships." Therefore, compounds like 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one not only serve as potent therapeutic agents but also as valuable points of exploration for future drug development.
Synonyms
Nordazepam
Nordiazepam
desmethyldiazepam
Norprazepam
1088-11-5
N-Desmethyldiazepam
Calmday
N-Demethyldiazepam
N-Deoxydemoxepam
Madar
1-Demethyldiazepam
N1-Desmethyldiazepam
Demethyldiazepam
Praxadium
Demadar
Stilny
Nordazepamum
Vegesan
N-Deoxydemoxapam
Nordazepam CIV
Ro 5-2180
Nordazepam [INN]
Lomax
Sopax
DMDZ
7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
N-Descyclopropylmethylprazepam
Nordazepamum [INN-Latin]
NSC 46078
A 101
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
Desoxydemoxepam
CCRIS 9181
A101
7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS 214-123-4
NSC-46078
Nordazepam (INN)
Calmday (TN)
NSC-631619
BRN 0751823
DTXSID2049000
CHEBI:111762
NORDAZEPAM [MI]
Ro 52180
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
CHEMBL523
67220MCM01
NORDAZEPAM [MART.]
NORDAZEPAM [WHO-DD]
7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on
NDZ
DTXCID3028926
NORDAZEPAM CIV [USP-RS]
5-24-04-00291 (Beilstein Handbook Reference)
NSC631619
NDD
NCGC00168263-01
Deoxydemoxepam
DIAZEPAM IMPURITY A [EP IMPURITY]
Nordaz
7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one
7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Nordazepamum (INN-Latin)
NORDAZEPAM (MART.)
7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-one
Desmethyldiazepam (Nordazepam)
DIPOTASSIUM CLORAZEPATE IMPURITY B [EP IMPURITY]
NORDAZEPAM CIV (USP-RS)
Nordazepam (1.0 mg/mL in Methanol)
N-Destrifluoroethylhalazepam
Desmethyl Diazepam
DIAZEPAM IMPURITY A (EP IMPURITY)
N-Descyclopropylmethyl-Prazepam
N Destrifluoroethylhalazepam
DIPOTASSIUM CLORAZEPATE IMPURITY B (EP IMPURITY)
N Descyclopropylmethylprazepam
N Descyclopropylmethyl Prazepam
DEA No. 2838
UNII-67220MCM01
Ro 5 2180
Diazepam-M N-desmethyl
ChemDiv1_028362
MixCom6_000554
Oprea1_578139
SCHEMBL78453
MLS001173623
DivK1c_000979
SCHEMBL26104098
HMS503C19
HMS667J04
KBio1_000979
N05BA16
NINDS_000979
7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
HMS2272B05
NSC46078
Tox21_113493
BDBM50027835
STK560158
Desmethyldiazepam, analytical standard
WLN: T67 GMV JN IHJ CG KR
AKOS000636746
AKOS005486646
DB14028
IDI1_000979
SMR000238153
CAS-1088-11-5
2H-1, 1,3-dihydro-7-chloro-5-phenyl-
2H-1, 7-chloro-1,3-dihydro-5-phenyl-
DB-040846
5-phenyl-7-chloro-1,4-benzodiazepin-2-one
NS00007814
7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-ol
C07486
D08283
Nordazepam (Nordiazepam) 0.1 mg/ml in Methanol
Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol
A801929
Desmethyldiazepam (Nordazepam), 1mg/ml in Methanol
Q3180288
7-chloro-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one
7-chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
(z)-7-chloro-5-phenyl-1h-benzo[e][1,4]diazepin-2(3h)-one
7-chloro-1,3 -dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one
7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one( am)
7-Chloro-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine
7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam)
7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(nordiazepam)
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; Nordazepam; Nordiazepam
7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(desmethyldiazepam)
214-123-4
Solubility of 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (C16H13ClN2O)
The solubility of 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one is a significant characteristic that can influence its application in various fields, particularly in pharmaceuticals. This compound, featuring both polar and non-polar functional groups, exhibits a range of solubility behaviors:
Understanding its solubility profile is crucial as it affects factors such as bioavailability, stability, and drug formulation. In conclusion, while 7-chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one demonstrates notable solubility in organic solvents, its limited water solubility may pose challenges in aqueous environments. Thus, careful consideration must be given to its formulation in therapeutic applications.