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Diazepam

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Identification
Molecular formula
C16H13Cl2N2O
CAS number
439-14-5
IUPAC name
7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
State
State

Diazepam is typically found in a solid state at room temperature. It is commercially available in tablet form for medicinal use.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
309.00
Boiling point (Kelvin)
582.00
General information
Molecular weight
284.70g/mol
Molar mass
284.7040g/mol
Density
1.3000g/cm3
Appearence

Diazepam appears as a white to yellowish crystalline powder. It is often odorless and may have a bitter taste.

Comment on solubility

Solubility of 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one (C16H13Cl2N2O)

The solubility of 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one can vary significantly based on several factors, particularly its chemical structure and the solvent used. Here are some important considerations regarding its solubility:

  • Polar vs. Nonpolar Solvents: This compound is likely to exhibit greater solubility in nonpolar solvents due to its hydrophobic aromatic rings. Conversely, its solubility in polar solvents (like water) may be limited.
  • Solubility Behavior: As a general characteristic of benzodiazepines, one might expect moderate solubility in organic solvents such as ethanol or methanol, while being less soluble in lighter hydrocarbons.
  • Effect of Temperature: Increasing the temperature typically enhances solubility in solids; thus, warming the solvent during experimentation could result in improved solubilization of the compound.
  • pH Influence: The ionization state of this compound may be affected by pH, altering its solubility profile. At different pH levels, one may observe either enhanced or reduced solubility.

In summary, the solubility of 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one is influenced by its chemical characteristics, solvent polarity, temperature, and environmental conditions such as pH. Understanding these factors is crucial for applications in pharmaceuticals and chemical formulations.

Interesting facts

Interesting Facts about 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

The compound 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one is a notable member of the benzodiazepine family, known for its profound pharmacological effects. Here are some intriguing aspects:

  • Pharmaceutical Uses: This compound is primarily utilized in the treatment of various anxiety disorders, insomnia, and muscle spasms. Its ability to enhance the effects of neurotransmitters in the brain provides a calming effect.
  • Chemical Structure: The benzodiazepine scaffold, characterized by a fusion of benzene and diazepine rings, is essential for its biological activity. Functional groups like the chlorine atoms play a crucial role in modulating its potency and selectivity.
  • Mechanism of Action: Benzodiazepines typically act as positive allosteric modulators of GABAA receptors. This means they increase the frequency of opening of the ion channel, leading to enhanced inhibition of neuronal activity.
  • Clinical Significance: 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one is also studied for its potential to further investigate and develop safer alternatives for anxiety and sleep disorders with fewer side effects.
  • Research and Development: As a subject of ongoing research, this compound presents opportunities for the synthesis of novel benzodiazepine derivatives, which aim to improve therapeutic outcomes while minimizing addiction risks.

In summary, 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one stands out for its therapeutic applications and the complexity of its structure, underlining the importance of chemical compounds in medicinal chemistry. As a future chemist or pharmacologist, understanding such compounds could be pivotal for innovation in pharmaceutical therapies.

Synonyms
4'-Chlorodiazepam
14439-61-3
Chlordiazepam
RO5-4864
4-Chlorodiazepam
Ro 5-4864
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
HSDB 6958
Ro-05-4864
BRN 0685202
7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
2QW0IK1742
Ro-5-4864
MLS000069627
CHEMBL286346
4-CHLORODIAZEPAM [HSDB]
DTXSID3041116
5-24-04-00337 (Beilstein Handbook Reference)
7-Chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
4'-CHLORODIAZEPAM [NFLIS-DRUG]
SMR000058205
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
4'-CHLORODIAZEPAM (NFLIS-DRUG)
7-Chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
UNII-2QW0IK1742
4 -chlorodiazepam
4' Cl-diazepam
4a(2)-Chlorodiazepam
Opera_ID_1710
Oprea1_280237
SCHEMBL60200
MLS001074199
DTXCID1021116
BDBM22040
CHEBI:232375
HMS2230H04
HMS3371O04
Ro-4864
PAA43961
PDSP1_000583
PDSP1_000636
PDSP1_001759
PDSP2_000580
PDSP2_000631
PDSP2_001742
4'-Chlorodiazepam, >=98% (TLC)
AKOS005066448
NCGC00018222-01
NCGC00018222-02
NCGC00018222-03
AS-73428
NS00005998
A11461
Q7339205
7-chloro-5-(4-chlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
(Z)-7-chloro-5-(4-chlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-(9CI)
7-Chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
634-296-3