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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-62-4
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, clonazepam exists as a solid. It is typically used in a compressed tablet form for medicinal purposes and is stable under normal temperatures and pressures.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
315.71g/mol
Molar mass
315.7140g/mol
Density
1.5200g/cm3
Appearence

Clonazepam appears as an off-white to light yellow crystalline powder. It is known to be sparingly soluble in water, meaning it does not dissolve well. Clonazepam is usually provided in a tablet form when used as a medication.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

The solubility of the compound 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one (C15H10ClFN2O) can be influenced by several factors. Here are the key points to consider:

  • Polarity: The presence of polar functional groups like the Cl (chlorine) and F (fluorine) atoms may increase interactions with polar solvents, such as water, indicating modest solubility under certain conditions.
  • Solvent Interaction: The compound may exhibit better solubility in organic solvents such as methanol or ethanol due to its hydrophobic aromatic structures.
  • Temperature Dependence: As with many chemical compounds, solubility can also vary significantly with temperature, generally increasing as the temperature rises.
  • pH Effects: If the chemical structure incorporates acidic or basic characteristics, solubility may be affected by the pH of the solvent, possibly resulting in increased solubility in more acidic or basic environments.

In summary, while definitive solubility data for 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one might not be widely available, the considerations above can help predict its behavior in different solvent systems. Always refer to specific experimental data or solubility testing for practical applications.

Interesting facts

Interesting Facts about 7-Chloro-5-(2-Fluorophenyl)-1-Methyl-3H-1,4-Benzodiazepin-2-One

The compound 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one is a member of the benzodiazepine family, which are widely recognized for their therapeutic properties. Here are some fascinating aspects of this compound:

  • Psychoactive Properties: Like many benzodiazepines, this compound may exhibit anxiolytic, sedative, or muscle relaxant effects, making it a candidate for research within the fields of psychiatry and neuropharmacology.
  • Structural Influences: The presence of both chlorine and fluorine in its structure can significantly affect the compound's receptor binding affinity and metabolism, leading to unique pharmacological profiles.
  • Synthetic Chemistries: The synthesis of such compounds is a topic of interest, as it combines various organic reactions, showcasing the ingenuity of organic chemistry in creating complex molecules through relatively straightforward pathways.
  • Research Potential: Due to its specific structure, this compound may be studied for new pharmacological applications, particularly in addressing unmet medical needs in anxiety and insomnia treatments.
  • Drug Design: This compound exemplifies how modifications in benzodiazepine structures can lead to tailored compounds that enhance efficacy or reduce side effects, which is a key focus in drug design and development.

In essence, 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one is not just a complex structure but a testament to the ongoing exploration in medicinal chemistry and the quest for better therapeutic agents. As one could say, “The future of medicine lies in the molecules we choose to explore.”


Synonyms
fludiazepam
Erispan
3900-31-0
Fludiazepamum [INN-Latin]
Fludiazepamum
Fludiazepam [INN:JAN]
Erispan (TN)
7-Chloro-5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
ID 540
BRN 0686115
CHEBI:31618
7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
7F64A2K16Z
FLUDIAZEPAM [MI]
FLUDIAZEPAM [INN]
FLUDIAZEPAM [JAN]
ID-540
FLUDIAZEPAM [MART.]
7-Chloro-5-(2-fluorophenyl)-1-methyl-1H-1,4-benzodiazepin-2(3H)-one
FLUDIAZEPAM [WHO-DD]
7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
DTXSID00192277
5-24-04-00320 (Beilstein Handbook Reference)
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-
7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Fludiazepamum (INN-Latin)
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-
FLUDIAZEPAM (MART.)
fludiazepan
Fludiazepam (1 mg/mL in Acetonitrile)
7-chloro-5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
UNII-7F64A2K16Z
DEA No. 2759
Fludiazepam (JP18/INN)
CHEMBL13291
SCHEMBL156039
Fludiazepam, 1mg/ml in Methanol
DTXCID10114768
N05BA17
DB01567
Ro-5-3438
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-(9CI)
NS00067970
D01354
Q3486981
1-methyl-5-(2-fluorophenyl)-7-chloro-1,3-dihydro-2H-(1,4)benzodiazepin-2-one
7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
ID 540; Ro 5-3438; 7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one; Erispan; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-Benzodiazepin-2-one