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Clorazepate

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Identification
Molecular formula
C16H11Cl2NOS
CAS number
23887-31-2
IUPAC name
7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one
State
State

At room temperature, clorazepate is in a solid state, typically in the form of crystalline powder.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
472.00
Boiling point (Kelvin)
745.15
General information
Molecular weight
316.24g/mol
Molar mass
316.1900g/mol
Density
1.3008g/cm3
Appearence

Clorazepate is a white to off-white crystalline powder that is odorless. Due to its crystalline nature, it may exhibit a granular appearance.

Comment on solubility

Solubility of 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one

The solubility of the compound 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one (C16H11Cl2NOS) is a critical aspect to consider for its applications and effectiveness. Here are some key points regarding its solubility:

  • Polarity: The presence of chlorine and nitrogen atoms alongside the benzothiazepine structure influences the overall polarity of the compound.
  • Solvent Interactions: This compound is likely more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or acetone, as opposed to polar solvents like water.
  • Temperature Dependence: Solubility may increase with temperature due to enhanced molecular motion, which can disrupt intermolecular interactions.
  • pH Effect: The solubility might also be affected by pH levels, particularly if it can ionize or exists in different protonation states in various environments.

In practical applications, the limited solubility in aqueous environments poses challenges for formulation and bioavailability. Understanding these facets is essential for leveraging the compound's properties effectively.

Interesting facts

Interesting Facts about 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one

This intriguing compound belongs to the class of benzothiazepines, which are known for their diverse pharmacological properties. As scientists explore the depths of its potential applications, several interesting aspects emerge:

  • Diverse Pharmacological Properties: Compounds in the benzothiazepine family are well-known for their ability to influence the central nervous system. They may exhibit anticonvulsant, antidepressant, and antihypertensive effects.
  • Structure-Activity Relationship: The presence of two chlorine atoms in the chemical structure plays a crucial role in modulating the compound's biological activity. These halogens can enhance lipid solubility and thus influence how the compound interacts with biological membranes.
  • Potential in Drug Design: The unique structure of this compound makes it a valuable candidate for medicinal chemistry research, particularly in the design of new therapeutics that target specific receptors in the brain.
  • Molecular Interactions: Understanding how this compound interacts at a molecular level with proteins or enzymes can unveil new pathways for therapeutic action, potentially leading to innovative treatments for various medical conditions.
  • Research Applications: Ongoing studies may present new findings related to its efficacy, safety profile, or possible side effects, making it a focal point in pharmaceutical research.

The potential of 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one continues to captivate chemists and pharmacologists alike as they delve deeper into its capabilities and applications in modern medicine.

Synonyms
75450-34-9
CGP37157
CGP 37157
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
CGP-37157
7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one
CHEMBL1495071
4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-
C15H11Cl2NOS
BSPBio_001556
KBioGR_000276
KBioSS_000276
SCHEMBL869274
CHEBI:91650
GTPL11611
KBio2_000276
KBio2_002844
KBio2_005412
KBio3_000551
KBio3_000552
YSSJ00988
DTXSID60996899
Bio1_000408
Bio1_000897
Bio1_001386
Bio2_000276
Bio2_000756
GLXC-15871
HMS1361N18
HMS1791N18
HMS1989N18
HMS3267K16
HMS3402N18
HMS3412I15
HMS3676I15
HMS3867M03
BDBM50139422
CM-119
HB1132
HSCI1_000330
AKOS024456390
CGP 37157?
IDI1_034026
NCGC00025008-02
NCGC00025008-03
HY-15754
MS-24819
DB-055958
CS-0008572
CGP-37157, >=98% (HPLC), powder
G13547
SR-01000597388
SR-01000597388-1
BRD-A35623999-001-02-4
BRD-A35623999-001-03-2
BRD-A35623999-001-04-0
BRD-A35623999-001-05-7
CGP-37157 - CAS 75450-34-9
Q27163475
7-Chloro-5-(2-chlorophenyl)-3,5-dihydro-4,1-benzothiazepin-2-ol
7-chloro-5-(2-chlorophenyl)-1,5-dihydrobenzo[e][1,4]thiazepin-2(3H)-2weeks
7-CHLORO-5-(2-CHLOROPHENYL)-3,5-DIHYDRO-1H-4,1-BENZOTHIAZEPIN-2-ONE