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7-Chloro-3',4,6-trimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione

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Identification
Molecular formula
C19H17ClO6
CAS number
/
IUPAC name
7-chloro-3',4,6-trimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
State
State

At room temperature, this compound is a solid. Due to its spiro structure, it maintains a crystalline form, though its powdery and slightly yellowish hue may vary depending on the level of purity.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
410.00
Boiling point (Kelvin)
683.15
General information
Molecular weight
368.79g/mol
Molar mass
368.7900g/mol
Density
1.4200g/cm3
Appearence

This compound appears as a solid crystalline substance. It exhibits a notable spiro structure that carries several methoxy groups, contributing to its unique chemical characteristics and appearance.

Comment on solubility

Solubility of 7-chloro-3',4,6-trimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione

The solubility of the compound C19H17ClO6 can be influenced by various factors, including its molecular structure and the presence of functional groups. Here are some considerations regarding its solubility:

  • Polarity: The presence of multiple methoxy groups suggests some level of polarity, which may enhance solubility in polar solvents such as water or alcohols.
  • Hydrophobic Interactions: The spiro structure and aromatic components may contribute to hydrophobic interactions, possibly reducing solubility in aqueous solutions.
  • Solvent Effects: Solubility can vary significantly depending on the solvent. For instance, its solubility is likely to be higher in organic solvents like dichloromethane or ethyl acetate.
  • Temperature Influence: Generally, higher temperatures can increase the solubility of organic compounds; thus, heating the solvent may facilitate better solubility.

In summary, while the specific solubility profile requires empirical data, the combination of polar and non-polar characteristics in C19H17ClO6 indicates that it may exhibit diverse solubility behavior across different solvents. To quote a general guideline: “The solubility of a compound is a matter of balance between polar and non-polar interactions.”

Interesting facts

Interesting Facts about 7-Chloro-3',4,6-Trimethoxy-5'-Methyl-Spiror[benzofuran-2,4'-cyclohex-2-ene]-1',3-Dione

This compound is a fascinating example of a synthetic organic molecule that showcases the beautiful complexity found in organic chemistry. Below are some interesting aspects to consider:

  • Structural Diversity: The presence of multiple functional groups, such as chloro, methoxy, and a unique spiro structure, makes this compound an excellent candidate for studying structure-activity relationships in medicinal chemistry.
  • Potential Applications: Compounds with benzofuran motifs are known for their biological activities, including anti-inflammatory and anticancer properties, making them subjects of interest in drug discovery.
  • Synthetic Routes: The synthesis of such complex molecules often involves multi-step processes, utilizing techniques such as reductive methylation and electrophilic aromatic substitution. This showcases the ingenuity required in organic synthesis.
  • Analog Synthesis: Due to its unique structure, researchers may explore analogs of this compound to optimize its pharmacological properties. This can lead to new therapeutic agents with improved efficacy and reduced side effects.
  • Challenges in Characterization: Characterizing the various stereoisomers and confirming their purity often involves advanced techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography.

As highlighted, the complexity and potential of 7-chloro-3',4,6-trimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione serve as a reminder of the continuous innovations in the field of organic chemistry. The study of such compounds not only enriches our understanding of chemical interactions but also opens doors to novel therapeutic solutions.

Synonyms
Gris-PEG
(+)-Griseofulvin
Fulvicin
Grifulvin V
78739-00-1
6915-11-3
7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
Griseostatin
Grisowen
Gricin
Griseo
MLS000028436
NSC34533
SMR000058317
Grisetin
7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
Fulvicin Bolus
Grisovin FP
Fulvicin-U/F
Griseofulvin, (+)-
Likunden
dl-Griseofulvin
Sporostatin xan
Spiro[benzofuran-2(3H),4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl
Opera_ID_606
Oprea1_256659
MLS001148597
MLS001183742
SCHEMBL686362
CHEMBL1369825
DTXSID20859239
HMS1607K07
HMS2231B24
HMS3369L02
Fulvidex (Veterinary) (Salt/Mix)
2884-22-2
7-Chloro-2',4,6-trimethoxy-6'.beta.-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
BCP19165
BCP19308
NSC41728
BBL005655
NSC-41728
STK177238
AKOS000715079
AKOS021990219
NCGC00017237-03
NCGC00017237-04
NCGC00017237-06
NCGC00089777-02
7-chloro-4,6,12-trimethoxy-14-methylspiro[2-hydrobenzo[b]furan-2,4'-cyclohexan e]-11-ene-3,10-dione
AC-32026
NCI60_003070
SY071186
VS-01589
EN300-51914
Gris-PEG; Grifulvin pound>>Griseofulvin pound>>Fulvicin-U-F
(5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
7-Chloro-2',4,6-trimethoxy-6'-methyl-spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione
7-Chloro-2a(2),4,6-trimethoxy-6a(2)-methylspiro[benzofuran-2(3H),1a(2)-[2]cyclohexene]-3,4a(2)-dione
Spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-
Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'.beta.-methyl-