Sulfamethoxypyridazine | Solubility of Things

Identification

Molecular formula

C₁₁H₁₁ClN₄O₃S

CAS number

80-35-3

IUPAC name

7-chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide

State

At room temperature, sulfamethoxypyridazine is in the form of a solid. Its crystalline structure and relative insolubility in water help maintain its solid state under normal conditions.

Melting point (Celsius)

209.00

Melting point (Kelvin)

482.00

Boiling point (Celsius)

526.50

Boiling point (Kelvin)

799.70

General information

Molecular weight

252.28g/mol

Molar mass

252.2800g/mol

Density

1.4900g/cm³

Appearence

Sulfamethoxypyridazine typically appears as a white to off-white crystalline powder. It is practically insoluble in water and soluble in acetone and ethanol, giving it a variable appearance depending on the specific preparation and solvent exposure.

Comment on solubility

Solubility of 7-chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide

The solubility of 7-chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide, represented by the chemical formula C₁₁H₁₁ClN₄O₃S, can be influenced by several key factors:

Polarity: The presence of sulfonamide and chlorinated functional groups impacts the overall polarity of the compound, suggesting that it may exhibit moderate solubility in polar solvents.
Solvent Interaction: It is likely to dissolve more readily in solvents such as dimethyl sulfoxide (DMSO) or methanol, which can stabilize interactions with polar or ionic groups.
pH Dependence: The solubility might increase in aqueous solutions at varying pH levels due to the ionization of the sulfonamide group, further assisting in solvation.

“Solubility is not merely a physicochemical property; it is a gateway to understanding the bioavailability and pharmacological potential of a compound.” This compound's solubility is crucial for its applications in medicinal chemistry, where it is essential for effective absorption in biological systems.

In summary, the solubility behavior of C₁₁H₁₁ClN₄O₃S may vary based on environmental factors and the specific solvent interactions, marking the importance of further empirical studies to establish precise solubility data.

Interesting facts

Interesting Facts about 7-Chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide

This compound is a fascinating example of a quinazoline derivative, which has garnered attention for its potential applications in medicinal chemistry. Below are some noteworthy aspects of this compound:

Antimicrobial Activity: Many compounds in the quinazoline family exhibit significant antimicrobial properties, making them important in the development of new antibiotics.
Targeted Drug Design: The sulfonamide moiety is known for its role in targeting bacterial enzymes, which can help in the development of drugs that are specific to certain pathogens.
Diverse Applications: This compound illustrates how modifications in chemical structure can lead to diverse biological activities. Researchers explore variations in substituents to tailor compounds for specific therapeutic applications.
Structure-Activity Relationship: Understanding the relationship between the structure of this compound and its biological activity is crucial for scientists aiming to optimize efficacy and minimize side effects.

As an important aspect of modern medicinal chemistry, the study of compounds like 7-chloro-2-methyl-3-(o-tolyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide not only enhances our understanding of chemical interactions but also paves the way for innovative therapies that can address resistant strains of bacteria.

Overall, this compound stands as a testament to the evolving field of chemical science, where every modification on a molecular level can corral innovative solutions for some of medicine's most pressing challenges.

Synonyms

metolazone

17560-51-9

Zaroxolyn

Mykrox

Diulo

Oldren

Metenix

Metalozone

Microx

Metolazona

Metolazonum

metozalone

Xuret

7-Chloro-2-methyl-4-oxo-3-(o-tolyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

Metolazonum [INN-Latin]

Metolazona [INN-Spanish]

6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-

SR 720-22

SR-720-22

Metazoline

Normelan

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Metolazone (Zaroxolyn)

7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide

HSDB 3367

2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone

UNII-TZ7V40X7VX

EINECS 241-539-3

TZ7V40X7VX

NSC-759581

7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide

BRN 0965506

DTXSID6045167

Metolazone, (+)-

Metolazone, (-)-

CHEBI:64354

7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

MFCD00069304

NM7V2Y3G0U

6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-

DTXCID4025167

5-25-09-00212 (Beilstein Handbook Reference)

6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-

NN9U607695

NSC 759581

Metolazone [USAN:USP:INN:BAN:JAN]

NCGC00093985-07

Metalazone

Metolazonum (INN-Latin)

Metolazona (INN-Spanish)

METOLAZONE (MART.)

METOLAZONE [MART.]

METOLAZONE (USP-RS)

METOLAZONE [USP-RS]

56436-32-9

METOLAZONE (EP IMPURITY)

METOLAZONE [EP IMPURITY]

METOLAZONE (EP MONOGRAPH)

METOLAZONE [EP MONOGRAPH]

METOLAZONE (USP MONOGRAPH)

METOLAZONE [USP MONOGRAPH]

Metolazone (USAN:USP:INN:BAN:JAN)

Zaroxolyn (TN)

56436-31-8

6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-, (+)-

6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-, (-)-

SMR001230730

SR-05000001765

Metolazon

Metolazone (JAN/USP/INN)

Metolazone; (2RS)-7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

Prestwick_333

CAS-17560-51-9

Metolazone (Standard)

Spectrum_000456

METOLAZONE [MI]

METOLAZONE [INN]

METOLAZONE [JAN]

Prestwick0_000112

Prestwick1_000112

Prestwick2_000112

Prestwick3_000112

Spectrum2_001741

Spectrum4_000229

Spectrum5_001237

METOLAZONE [HSDB]

METOLAZONE [USAN]

METOLAZONE [VANDF]

CHEMBL878

UNII-NM7V2Y3G0U

METOLAZONE [WHO-DD]

SCHEMBL40558

BSPBio_000124

BSPBio_002422

KBioGR_000897

KBioSS_000936

MLS002153316

MLS002154200

DivK1c_000275

SPECTRUM2300325

SPBio_001842

SPBio_002063

BPBio1_000138

GTPL4838

METOLAZONE [ORANGE BOOK]

UNII-NN9U607695

BDBM25899

HMS500N17

HY-B0209R

KBio1_000275

KBio2_000936

KBio2_003504

KBio2_006072

C03BA08

NINDS_000275

BCPP000166

HMS1568G06

HMS1922L16

HMS2093P14

HMS2095G06

HMS2230J15

HMS3261J22

HMS3373C11

HMS3655M09

HMS3712G06

HMS3744I19

Pharmakon1600-02300325

-tetrahydroquinazoline-6-sulfonamide

BCP21574

HY-B0209

Tox21_110186

Tox21_113526

Tox21_500610

CCG-39450

NSC759581

s1610

AKOS015897109

Metolazone, >=98% (HPLC), solid

Tox21_110186_1

BCP9000920

DB00524

FM25978

KS-5139

LP00610

SDCCGSBI-0051460.P003

IDI1_000275

NCGC00093985-01

NCGC00093985-02

NCGC00093985-03

NCGC00093985-04

NCGC00093985-05

NCGC00093985-06

NCGC00093985-08

NCGC00093985-10

NCGC00093985-11

NCGC00093985-20

NCGC00261295-01

AS-13016

SBI-0051460.P002

DB-044227

AB00052055

NS00004329

SW196612-3

D00431

7-chloro-2-methyl-4-oxo-3-o-tolyl-1,2,3,4

AB00052055-08

AB00052055_09

AB00052055_10

EN300-23818025

Q1169561

SR-05000001765-1

SR-05000001765-4

SR-05000001765-7

BRD-A61793559-001-05-7

BRD-A61793559-001-08-1

BRD-A61793559-001-14-9

BRD-A61793559-001-15-6

BRD-A61793559-001-16-4

Metolazone, European Pharmacopoeia (EP) Reference Standard

Metolazone, United States Pharmacopeia (USP) Reference Standard

7-CHLORO-1,2,3,4-TETRAHYDRO-2-METHYL-4-OXO-3-TOLYL-6-QUINAZOLINESULFONAMIDE

7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydro-6-quinazolinesulfonamide #

7-chloro-2-methyl-4-oxo-3-o-tolyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

Metolazone for system suitability, European Pharmacopoeia (EP) Reference Standard

241-539-3

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;Diulo;2-Methyl-3-(o-tolyl)-6-sulfamyl-7-chlor