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Amitriptyline

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Identification
Molecular formula
C19H23ClN2
CAS number
50-48-6
IUPAC name
7-chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine
State
State

At room temperature, amitriptyline is typically in the form of a solid powder or crystalline form.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
324.00
Boiling point (Kelvin)
597.15
General information
Molecular weight
313.87g/mol
Molar mass
313.8650g/mol
Density
1.2694g/cm3
Appearence

Amitriptyline typically appears as a white or light yellow crystalline powder. It is usually tasteless and odorless.

Comment on solubility

Solubility of 7-chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine (C19H23ClN2)

The solubility of 7-chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine can be influenced by several factors, given its complex structure and composition. Generally speaking, the solubility characteristics of chemical compounds are governed by:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents like water.
  • Molecular Weight: Larger molecules often demonstrate lower solubility due to increased molecular interactions that hinder dissolution.
  • Temperature: Increased temperature typically increases solubility for solids in liquids, as it provides energy to break intermolecular forces.
  • pH of the solvent: Changes in pH can affect the ionization of compounds, thereby impacting their solubility.

For compounds akin to C19H23ClN2, *i.e.*, those with multiple rings and nitrogen atoms, one might expect variability in solubility. Anecdotal evidence suggests that such complex structures may exhibit poor solubility in water but could be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
As with many organic compounds, studying empirical data is crucial to ascertain precise solubility conditions. It is important to remember that “**like dissolves like**”; hence, a thorough solvent compatibility assessment should be conducted for practical applications.

Interesting facts

Interesting Facts About 7-Chloro-15-Ethyl-10-Azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine

This compound, known for its complex structure and intriguing properties, belongs to a class of organic compounds that display remarkable biological activity. Here are several noteworthy aspects:

  • Natural and Synthetic Origins: Many compounds like this one are inspired by natural products, particularly those found in medicinal plants. Their synthetic variations can enhance binding affinity to biological targets.
  • Potential Biological Applications: Compounds featuring chloro and amine functional groups are often explored for their potential as pharmaceuticals. This particular compound may exhibit properties suitable for use in antiviral or anticancer therapies.
  • Complex Molecular Structure: The tetracyclic structure of this compound makes it particularly interesting for chemists as it presents unique challenges in synthesis and offers diverse reactivity options.
  • Structure-Activity Relationship (SAR): Understanding how structural changes affect biological activity is crucial. Modifications at different positions on the ring system can lead to varying potency and selectivity.
  • Research Significance: Ongoing studies focus on the pharmacological effects of this compound, with aims to uncover its mechanism of action, signaling pathways, and potential side effects.

As scientists delve deeper into the fascinating world of chemical compounds, compounds like 7-chloro-15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine remind us of the boundless possibilities in medicinal chemistry and the never-ending quest for new and effective treatments. "Science knows no boundaries," as the famous saying goes, and each compound opens the door to new horizons.

Synonyms
huprine x
rac-huprine H7
CHEMBL143812
SCHEMBL7115053
BDBM10597
DTXSID901336714
NCI60_041180
AN-907/40848043
(1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine
7-chloro-15-ethyl-(1R,13S)-10-azoniatetracyclo[11.3.1.02,11.04,9]heptadeca-2,4,6,8,10,14-hexaen-3-amine
7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0~2,11~.0~4,9~]heptadeca-2(11),3,5,7,9,14-hexaen-3-ylamine