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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
State
State

Clonazepam is typically found in a solid state at room temperature, appearing as tablets or a crystalline powder. It is often administered orally in tablet form.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
410.00
Boiling point (Kelvin)
683.15
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
1.9000g/cm3
Appearence

Clonazepam is a white to crystalline powder. It is odorless or nearly odorless and appears as a colorless or pale yellow substance in its solid form.

Comment on solubility

Solubility of 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione

The solubility of 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione (C15H10ClN3O3) can be characterized by several factors:

  • Polarity: The presence of the chloro group (Cl) and the nitrogen (N) atoms suggests that the compound has some polar character. However, the overall structure also includes a large aromatic system, which can contribute to hydrophobic interactions.
  • Solvent Compatibility: It is expected to exhibit solubility in organic solvents due to its hydrophobic regions, while potentially being less soluble in polar solvents like water.
  • Temperature Dependence: Like many compounds, its solubility may increase with temperature, which can encourage the dissolution of such compounds in solvents.
  • pH Sensitivity: As an organic compound, solubility may also vary with pH, especially if ionic forms are possible under different pH conditions.

In summary, while 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione is likely to show limited solubility in water, it may be more readily soluble in organic solvents. As is often the case, understanding its solubility profile is essential for determining its practical applications and behavior in various environments.

Interesting facts

Interesting Facts about 7-Chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione

The compound 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione is a fascinating member of the benzodiazepine family, which is renowned for its pharmacological properties. Here are several compelling facts about this compound:

  • Pharmacological Significance: Like other benzodiazepines, this compound is believed to interact with the central nervous system, potentially exhibiting anxiolytic, sedative, and anticonvulsant effects.
  • Synthetic Applications: It serves as an important scaffold for developing new drugs due to its versatile structure, making it a valuable compound in medicinal chemistry.
  • Structure-Activity Relationship: The presence of the chlorine atom and the methyl group plays a crucial role in modifying the compound's biological activity, showcasing the significance of substitution patterns in drug design.
  • Research Potential: Ongoing research explores its potential in treating anxiety and sleep disorders, which is an area of great interest in pharmaceutical sciences.
  • Descriptive Name: The name of the compound itself highlights its complex structure and varying functional groups, reflecting its intricate chemistry.

As a chemistry student or scientist, understanding compounds like this is instrumental in grasping how slight changes in molecular structures can lead to significant differences in biological activity and therapeutic uses. These insights are cornerstones of drug development and therapeutic innovation.

Conclusion

With its intricate structure and promising biological activity, 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione exemplifies the intersection of chemistry and medicine. The exploration of such compounds continues to inspire innovation and research in the quest for effective therapeutic agents.

Synonyms
Clobazam
Frisium
Urbanyl
Chlorepin
Clorepin
Urbadan
22316-47-8
Onfi
Clobazamum
Mystan
LM-2717
HR 376
Caastilium
Noiafren
Odipam
Urbanil
H-4723
LM 2717
RU-4723
H 4723
Clobazamum [INN-Latin]
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-
HR-376
CCRIS 7506
Colbazam
Urbanol
NSC 336279
CHEBI:31413
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
EINECS 244-908-7
UNII-2MRO291B4U
7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
NSC-336279
BRN 0758410
SYMPAZAN
2MRO291B4U
DTXSID2046759
DTXCID0026759
HSDB 8343
5-24-08-00034 (Beilstein Handbook Reference)
NSC336279
NCGC00168249-01
Clobazamum (INN-Latin)
CLOBAZAM (MART.)
CLOBAZAM [MART.]
Clobazam (1mg/ml in Methanol)
CLOBAZAM (EP MONOGRAPH)
CLOBAZAM [EP MONOGRAPH]
Clobazepam
Clobazam (1mg/ml in Acetonitrile)
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
Mystan (TN)
Clobazam (JAN/USAN/INN)
Clobazam [USAN:INN:BAN]
Perizam
Tapclob
DEA No. 2751
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo(b)(1,4)diazepine-2,4-dione
Clobazamum (Latin)
Onfi (TN)
CLOBAZAM [USAN]
CLOBAZAM [INN]
CLOBAZAM [JAN]
CLOBAZAM [MI]
CLOBAZAM [VANDF]
COLBAZAM [VANDF]
CLOBAZAM [WHO-DD]
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine
SCHEMBL43038
MLS003899217
CHEMBL70418
Clobazam, 1mg/ml in Methanol
CLOBAZAM [ORANGE BOOK]
GTPL7149
Clobazam 0.1 mg/ml in Methanol
Clobazam 1.0 mg/ml in Methanol
N05BA09
HY-A0041
Tox21_112608
BDBM50247888
AKOS025401921
CS-6756
DB00349
SMR000058811
WLN: T67 GNV JVN IHJ CG G1 KR
CAS-22316-47-8
DB-045870
NS00010408
C-2991
D01253
Q412164
SR-01000937603
SR-01000937603-2
7-Chloro-1-methyl-5-phenyl-1H-1,4(3H,5H)-dione
7-Chloro-1-methyl-5-phenyl-1H-1,4-(3H,5H)-dione
BRD-K52408781-001-02-8
1H-1,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-
7-Chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione
1-phenyl 5-methyl 8-chloro 1,2,4,5-tetrahydo 2,4-dioxo 3H-1,5-benzodiazepine
1-phenyl 5-methyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine
1-Phenyl-5-methyl-8-chloro-1,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
244-908-7