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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Clonazepam is in a solid state, existing as a crystalline powder.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
1.4100g/cm3
Appearence

Clonazepam is a white to very light yellow crystalline powder. It is practically insoluble in water but freely soluble in acetone, soluble in methanol, and freely soluble in ethanol.

Comment on solubility

Solubility of 7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one (C15H10ClN3O3)

The solubility profile of 7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one offers interesting insights into its interaction with various solvents. Several factors contribute to its solubility characteristics:

  • Polarity: This compound possesses polar functional groups, including a chloride atom and amine groups, which can enhance its solubility in polar solvents.
  • Hydrogen bonding: The presence of nitrogen and oxygen atoms makes it capable of forming hydrogen bonds, which can facilitate its solubility in protic solvents like water.
  • Hydrophobic regions: The phenyl and cyclopropylmethyl groups contribute to hydrophobic interactions, suggesting limited solubility in non-polar solvents.

In general, it is expected that:

  1. This compound is more soluble in polar organic solvents such as ethanol or methanol.
  2. It may show limited solubility in water due to its hydrophobic characteristics.
  3. Solubility can vary significantly with temperature and pH changes as well.

Therefore, assessing the solubility of this benzodiazepine derivative is essential for understanding its potential biological activity and therapeutic applications.

Interesting facts

Interesting Facts about 7-Chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one

7-Chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one is a fascinating compound belonging to the benzodiazepine family, which is well-known for its medicinal properties. Here are some intriguing aspects of this compound:

  • Therapeutic Potential: Benzodiazepines are primarily recognized for their applications as anxiolytics, sedatives, and anticonvulsants. This particular compound may exhibit unique pharmacological behavior due to its specific substitutions, warranting further research into its potential therapeutic benefits.
  • Structural Diversity: The presence of a chloro group and a cyclopropylmethyl moiety in its structure introduces variability that can significantly influence the compound's biological activity. This opens up a realm of possibilities for designing derivatives with enhanced effects.
  • Synthetic Pathways: The synthesis of compounds in the benzodiazepine class often involves intricate organic reactions. Chemists may employ techniques such as cyclization and substitution reactions to construct these complex architectures, highlighting the artistry of synthetic chemistry.
  • Research Significance: Studying such compounds can lead to a deeper understanding of the mechanisms of action of benzodiazepines, which can pave the way for developing safer alternatives with fewer side effects.

As the field of medicinal chemistry evolves, compounds like 7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one remind us of the intricate relationship between chemical structure and biological function. The ongoing exploration of these compounds not only enhances our knowledge but also fuels advancements in pharmaceuticals aimed at improving human health.

Synonyms
prazepam
Demetrin
Lysanxia
Trepidan
Verstran
Centrax
2955-38-6
Prazepamum
Prazepamum [INN-Latin]
W 4020
Prazepam civ
K-373
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-
NSC 277179
EINECS 220-975-8
UNII-Q30VCC064M
W-4020
NSC-277179
7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
BRN 0895797
Q30VCC064M
DTXSID4021181
7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one
7-Chloro-1-cyclopropylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
CHEBI:8362
DTXCID101181
Prazene
Sedapran
7-Chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-PHENYL-
Prazepam [USAN:USP:INN:BAN:JAN]
NCGC00168256-01
Prazeene
Settima
PRAZEPAM (IARC)
PRAZEPAM [IARC]
Prazepamum (INN-Latin)
PRAZEPAM (MART.)
PRAZEPAM [MART.]
PRAZEPAM CIV (USP-RS)
PRAZEPAM CIV [USP-RS]
Prazepam (1mg/ml in Methanol)
PRAZEPAM (EP MONOGRAPH)
PRAZEPAM [EP MONOGRAPH]
Prazepam (USAN:USP:INN:BAN:JAN)
Prazepam (1.0mg/ml in Acetonitrile)
7-chloro-1-(cyclopropylmethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Centrax (TN)
CAS-2955-38-6
DEA No. 2764
PRAZEPAM [USAN]
PRAZEPAM [INN]
PRAZEPAM [JAN]
PRAZEPAM [MI]
PRAZEPAM [VANDF]
CHEMBL969
PRAZEPAM [WHO-DD]
SCHEMBL78272
MLS003899231
Prazepam, 1mg/ml in Methanol
PRAZEPAM [ORANGE BOOK]
GTPL7275
Prazepam (JP18/USAN/INN)
N05BA11
Prazepam 0.1 mg/ml in Methanol
Prazepam 1.0 mg/ml in Methanol
Tox21_112615
Tox21_200076
NSC277179
Prazepam 1000 microg/mL in Methanol
DB01588
NCGC00168256-02
NCGC00257630-01
SMR000058725
DB-047601
NS00010420
C07366
D00470
WLN: T67 GNV JN IHJ CG KR& G1- AL3TJ
Q2149443
7-Chloro-1-(cyclopropylmethyl)-1,4-benzodiazepin-2-one
Prazepam, European Pharmacopoeia (EP) Reference Standard
2H-1, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl-
2H-1, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-
Prazepam, United States Pharmacopeia (USP) Reference Standard
7-Chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
220-975-8