Interesting facts
Interesting Facts about 7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
This intriguing compound is part of the benzodiazepine class, which is widely recognized for its pharmacological properties. Some noteworthy aspects include:
- Pharmacological Role: Benzodiazepines are primarily known for their effects as anxiolytics, showing promise in managing anxiety disorders, insomnia, and seizure disorders.
- Structure-Activity Relationship (SAR): The presence of a chloro group (7-chloro) and a fluorophenyl moiety enhances its receptor binding affinity, often contributing to its potency.
- Diethylamino Substituent: The 2-(diethylamino)ethyl group increases lipophilicity, which can affect the compound’s bioavailability and its ability to cross the blood-brain barrier, leading to central nervous system effects.
- Emerging Studies: Research into benzodiazepine derivatives continues to explore their potential for treating various neuropsychiatric conditions, reflecting ongoing interest in their therapeutic applications.
- Safety and Regulations: As a compound belonging to the benzodiazepine family, it is important to consider its use with caution due to the potential for dependency and withdrawal symptoms.
A fascinating characteristic of this compound is its ability to modulate the GABAA receptor, which plays a crucial role in inhibitory neurotransmission. This activity underscores the significance of benzodiazepines in both therapeutic and research contexts. As stated by some researchers, "the unique structural elements of this compound provide an interesting landscape for drug development."
Continued investigations into compounds like this one can pave the way for innovative treatments that enhance patient outcomes while minimizing side effects.
Synonyms
flurazepam
17617-23-1
Insumin
Flurazepamum
Dalmane-R
Dalmane
Flurazepam HCL
Flurazepamum [INN-Latin]
HSDB 3085
Ro-5-6901/3
EINECS 241-591-7
UNII-IHP475989U
BRN 0767925
DTXSID1023071
IHP475989U
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CHEBI:5128
DTXCID803071
Stauroderm
Noctosom
5-24-04-00322 (Beilstein Handbook Reference)
Ro-56901
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-
DEA No. 2767
NCGC00164573-01
Ro 56901/3
Felmane
Flurazepamum (INN-Latin)
FLURAZEPAM (MART.)
FLURAZEPAM [MART.]
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-
Flurazepam [INN:BAN:JAN]
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(2-(DIETHYLAMINO)ETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO
7-CHLORO-1-(2-(DIETHYLAMINO)ETHYL)-5-(O-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Insumin (TN)
CAS-17617-23-1
N'-[2-[2,4-(Dimethylphenyl)thio]phenyl] Vortioxetine
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(2-(DIETHYLAMINO)ETHYL)-5-(O-FLUOROPHENYL)-1,3-DIHYDRO-
7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
N,N'-Bis[2-[(2,4-imethylphenyl)thio]phenyl]-piperazine; 1,4-Bis(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
FLURAZEPAM [MI]
Flurazepam (JAN/INN)
FLURAZEPAM [INN]
FLURAZEPAM [JAN]
FLURAZEPAM [HSDB]
FLURAZEPAM [VANDF]
CHEMBL968
FLURAZEPAM [WHO-DD]
SCHEMBL29793
GTPL7188
Flurazepam, 1mg/ml in Methanol
17617-23-1(free base)
N05CD01
Flurazepam 0.1 mg/ml in Methanol
Flurazepam 1.0 mg/ml in Methanol
Tox21_112201
AKOS015889971
Tox21_112201_1
DB00690
NCGC00164573-02
DB-044253
NS00010460
D00329
A812156
Q418998
7-chloranyl-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
(E)-7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
241-591-7
7-CHLORO-1-(2-(DIETHYLAMINO)ETHYL)-5-(2-FLUOROPHENYL)-1H-1, 4-BENZODIAZEPIN- 2(3H)-ONE
7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
7-Chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
FL7
Solubility of 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
The solubility of 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one (C16H13ClFN2O) varies significantly based on the solvent used. Here are some key points regarding its solubility:
In conclusion, while the solubility of this compound can be characterized as moderate, it is highly influenced by the choice of solvent and the environmental conditions. As is often the case with complex organic molecules, assessing solubility is crucial for applications in pharmaceuticals, where formulations may greatly depend on the solubility profiles of active ingredients.