Skip to main content

Bromazepam

ADVERTISEMENT
Identification
Molecular formula
C14H10BrN3O
CAS number
1812-30-2
IUPAC name
7-bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one
State
State
Bromazepam is generally found in solid form at room temperature, especially as a crystalline powder or as compressed tablets designed for oral administration.
Melting point (Celsius)
237.00
Melting point (Kelvin)
510.15
Boiling point (Celsius)
544.08
Boiling point (Kelvin)
817.23
General information
Molecular weight
316.15g/mol
Molar mass
316.1540g/mol
Density
1.2290g/cm3
Appearence

Bromazepam is a white or yellowish crystalline powder that is easily identifiable due to its distinct coloring. The compound is available in tablet form for pharmaceutical use, where it is commonly pressed into a solid texture, but in laboratory form, it retains its powdery nature.

Comment on solubility

Solubility of 7-bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one

The solubility of 7-bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one (C14H10BrN3O) can be quite intriguing due to its complex structure. Here are some key points to consider regarding its solubility:

  • Solvent Dependency: The solubility of this compound is likely to vary significantly depending on the solvent used. It may exhibit better solubility in organic solvents such as ethanol or DMSO than in water.
  • Polar vs Non-Polar: Given the presence of both polar and non-polar functional groups, the compound may have amphipathic characteristics, influencing its interaction in polar and non-polar environments.
  • Effects of Temperature: As with many organic compounds, an increase in temperature may enhance solubility, allowing for greater dissolution in select solvents.
  • pH Dependence: The solubility can also be affected by the pH of the solution, particularly due to the presence of nitrogen atoms which may participate in protonation reactions.

In conclusion, while specific solubility values may vary, understanding the factors that influence the solubility of 7-bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one can aid researchers in selecting appropriate solvents for experimentation.

Interesting facts

Exploring 7-Bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one

7-Bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one is a fascinating compound belonging to the benzodiazepine class, renowned for its significant presence in both pharmacology and organic chemistry. Here are several intriguing aspects of this compound:

  • Benzodiazepines and Beyond: This compound is part of a larger family known for their effects on the central nervous system, acting primarily as anxiolytics, sedatives, and muscle relaxants.
  • Substituent Significance: The presence of the bromo group can enhance the compound's reactivity and influence its biological activity, making it an interesting subject for medicinal chemistry.
  • Pyridine Linkage: The attached 2-pyridyl group has potential implications for how this compound interacts with various biological targets, opening avenues for drug design.
  • Research Applications: Investigating this compound can contribute to a deeper understanding of mental health treatments, especially concerning anxiety disorders and insomnia.
  • Structural Variety: Benzodiazepine derivatives exhibit a wide range of chemical properties and pharmacological effects, emphasizing the importance of modest structural modifications.

The exploration of 7-bromo-5-(2-pyridyl)-1,3-dihydro-1,4-benzodiazepin-2-one offers not just insights into its structure and reactivity, but also opens up discussions on its potential therapeutic applications. As quoted in the scientific community, "Every modification in a benzodiazepine structure can yield a new therapeutic potential." This highlights the relevance of compounds like this in ongoing research.

Overall, the compound exemplifies the intersection of chemistry and medicine, embodying the intricate relationship between molecular architecture and biological function.

Synonyms
bromazepam
Lexotanil
Compedium
Durazanil
Lectopam
Lexotan
Creosedin
Lekotam
Lexaurin
Lexilium
1812-30-2
Calmepam
Compendium
Lexomil
Normoc
Ultramidol
LA Xvii
Bromazepamum [INN-Latin]
Ro 5-3350
Bromazepamum
Bromazepamum [Latin]
Lexatin
Bromazepam civ
7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one
Lectopam (TN)
7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
Bromazepam [USAN:INN:BAN:JAN]
NSC 140669
2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
EINECS 217-322-4
NSC-140669
BRN 0618645
7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one
1,3-Dihydro-7-bromo-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzdiazepin-2-one
X015L14V0O
BROMAZEPAM [MI]
BROMAZEPAM [INN]
BROMAZEPAM [JAN]
BROMAZEPAM [USAN]
BROMAZEPAM [MART.]
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-pyridyl)-
BROMAZEPAM [WHO-DD]
2H-1,4-BENZODIAZEPIN-2-ONE, 7-BROMO-1,3-DIHYDRO-5-(2-PYRIDYL)-
RO-5-3350
7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
BROMAZEPAM CIV [USP-RS]
BROMAZEPAM [EP MONOGRAPH]
DTXSID40171081
5-26-05-00078 (Beilstein Handbook Reference)
Bromazepamum (Latin)
Bromazepamum (INN-Latin)
BROMAZEPAM (MART.)
Pasca;oi,
BROMAZEPAM CIV (USP-RS)
BROMAZEPAM (EP MONOGRAPH)
Bromazepam (1mg/mL in Methanol)
7-bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
7-bromo-5-(pyridin-2-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Bromazepam (100?g/ml in Methanol)
Ro 53350
Ro 4-9253
7-Bromo-5-[2-pyridyl]-3H-1,4-benzodiaxepin-2[1H]-one
UNII-X015L14V0O
DEA No. 2748
SCHEMBL43933
MLS003899212
Bromazepam, analytical standard
CHEMBL277062
Bromazepam, 1mg/ml in Methanol
Bromazepam (JP17/USAN/INN)
DTXCID8093572
CHEBI:31302
N05BA08
7-Bromo-1,4-benzodiazepin-2-one
Bromazepam 0.1 mg/ml in Methanol
Bromazepam 1.0 mg/ml in Methanol
NSC140669
DB01558
FB19015
SMR000058724
WLN: T67 GMV JN IHJ CE K- BT6NJ
NS00008673
D01245
2H-1, 7-bromo-1,3-dihydro-5-(2-pyridyl)-
2H-1, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
Bromazepam, drug standard, 1.0 mg/mL in methanol
Q422435
Bromazepam, European Pharmacopoeia (EP) Reference Standard
Bromazepam, United States Pharmacopeia (USP) Reference Standard
7-Bromo-5-(pyridin-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
(E)-7-bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
7-Bromo-5-(2-pyridinyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
7-Bromo-1,3-dihydro-5-(2-pyridinyl)-2H-1,4-benzodiazepin-2-one;Compendium;Creosedin
217-322-4