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Methylene Blue

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Identification
Molecular formula
C16H18ClN3S
CAS number
61-73-4
IUPAC name
(7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;chloride
State
State
Methylene Blue is typically in a solid state at room temperature, appearing as a crystalline powder.
Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
319.85g/mol
Molar mass
319.8520g/mol
Density
1.0528g/cm3
Appearence

Methylene Blue typically appears as a dark green crystalline powder when in its solid state. When dissolved in water, it forms a deep blue solution. The crystalline powder itself has a metallic sheen.

Comment on solubility

Solubility of (7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;chloride

The solubility of the compound (7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;chloride, often referred to as a quaternary ammonium compound, is influenced by various factors. As a salt, it typically exhibits good solubility in polar solvents. Here are some key points regarding its solubility:

  • Water Solubility: Due to the presence of the chloride ion as part of its structure, this compound is expected to be soluble in water, enabling it to dissolve readily in aqueous solutions.
  • Solubility in Organic Solvents: While it may not dissolve well in non-polar solvents, it can show varying degrees of solubility in organic solvents such as methanol and ethanol, depending on their polarity.
  • Temperature Dependence: The solubility of salts often increases with temperature. Therefore, heating the solvent may enhance the solubility of the compound.

It is important to note that ionic interactions play a significant role in dissolution. The cationic nature of the ammonium group and the anionic chloride facilitate the solubility process, breaking apart in solution to allow for increased interaction with solvent molecules. As a general observation, the structural characteristics of the compound, including size and charge distribution, heavily impact its solubility behavior.

Interesting facts

Interesting Facts about (7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;chloride

This compound, often utilized in various scientific fields, presents a fascinating array of properties and applications that make it worthy of study. Below are some intriguing aspects of this compound:

  • Diverse Applications: It is frequently employed in the realm of pharmaceuticals, particularly as an effective agent in antipsychotic medications. Compounds in the phenothiazine family are known for their ability to influence neurotransmitter pathways, thus aiding in the treatment of various mental health disorders.
  • Structure Insights: The chemical structure includes a phenothiazine scaffold, which contributes to its unique reactivity and interaction with biological systems. The functional groups provide sites for potential modifications, opening pathways to derivative compounds with enhanced therapeutic effectiveness.
  • Experimental Utility: In laboratory settings, the compound can serve as a valuable tool in studying the dynamics of cell signaling and neurotransmitter interactions. This has profound implications for research into neurobiology and the development of targeted therapies.
  • Literature Presence: The compound and its derivatives are often referenced in academic journals, highlighting its significance. It’s essential for students to stay abreast of ongoing research that cites this compound, as it may showcase emerging trends in medicinal chemistry.
  • Safety Considerations: As with many chemical agents, it is crucial for researchers to handle this compound with care, understanding both its therapeutic potential and the safety protocols necessary for its use in laboratory and clinical settings.

As a statement from the field of pharmaceuticals puts it best: "Innovative compounds continue to pave the way for breakthroughs in mental health treatment, and (7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;chloride is no exception." This compound serves as a reminder of the intricate relationship between chemical structure and biological function, making it a valuable subject of study in both academic and practical contexts.

Synonyms
Toluidine Blue O
Toluidine Blue
92-31-9
TOLONIUM CHLORIDE
Basic Blue 17
Blutene chloride
Tolazul
Gabilin
Menodin
C.I. Basic Blue 17
Blutene
Toluidine Blue OO
Klot
Toloni chloridum
Schultz 1041
Cloruro de tolonio
F Klot
Chlorure de tolonium
Toluidene Blue O Chloride
Toluidinblau
Dimethyltoluthionine chloride
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
Schultz no. 1041
Tolonii chloridum
Tolonium chloride [INN]
C.I. 52040
C.I. 925
MFCD00011934
3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
(7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium;chloride
ci 52040
3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride
NSC-11225
NSC-36758
15XUH0X66N
DTXSID9048728
CHEBI:87647
DTXCID6028654
Toluidinblau [German]
MLS000738130
Modr Toluidinova
Modr Toluidinova [Czech]
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)
Toluidine Blue (phenothiazine dye)
CAS-92-31-9
Modr Zasadita 17 [Czech]
Modr Zasadita 17
NSC11225
CCRIS 4933
Tolonii chloridum [INN-Latin]
Cloruro de tolonio [INN-Spanish]
Chlorure de tolonium [INN-French]
Dimethyltoluthionine chloride (VAN)
NCGC00181775-01
EINECS 202-146-2
NSC 11225
UNII-15XUH0X66N
3-Amino-7-Dimethylamino-2-methylphenazathionium chloride
Toluidine Blue?
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1); Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (8CI,9CI); 3-Amino-7-(dimethylamino)-2-methylphenazathionium chloride; 3-Amino-7-(dimethylamino)-2-methylphenothiazi
Toluidine Blue 00
Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
Toluidine Blue O, 80%
Toluidine Blue O, 85%
Toluidine Blue O Certified
3-Amino-7-dimethylamino-2-methylphenazathionium
C.I.BASIC BLUE 17
SCHEMBL122592
SCHEMBL338335
TOLONIUM CHLORIDE [MI]
Toluidine Blue O, certificated
CHEMBL1790006
Toluidine Blue, phenothiazine dye
TOLONIUM CHLORIDE [MART.]
HMS1545F05
HMS2752P23
HMS3264B13
Pharmakon1600-01506191
Toluidine Blue O, Technical grade
TOLONIUM CHLORIDE [WHO-DD]
HY-D0220
NSC36758
Tox21_113159
CI 524
NSC760421
AKOS015916405
AKOS024282653
n-(7-amino-8-methyl-3h-phenothiazin-3-ylidene)-n-methylmethanaminium chloride
Tox21_113159_1
CCG-213755
FT47177
NSC-760421
NCGC00181775-02
DA-68252
SY078344
TS-07638
CS-0010132
T0571
D92363
E79432
Q80868
SBI-0653505.0001
T16100
TOLUIDINE BLUE O (DYE CONTENT, ~80%)
SR-01000760899
WLN: T C666 BN ISJ E1 FZ LN1&1 &G
SR-01000760899-2
Toluidine Blue O, certified by the Biological Stain Commission
37251-80-2